Progesterone in 2nd trimester

by Brooke

I'm currently 16w 3days pregnant. I took progesterone vaginally for 13weeks and stopped. I had a blood test at 13 weeks to check progesterone levels it was 70 and then tested after I stopped the progesterone 6 days later it dropped to 40.

I had my doctor recheck my levels again at 16 weeks it dropped again to 28. My ob doctor said it's normal to drop when you are entering your second trimester. I have never heard of progesterone dropping but increasing during pregnancy. I'm concerned that the dropping levels will keep on dropping and go into labor. Do I need to be put back on progesterone suppositories again I took 100mg twice a day?

Comments for Progesterone in 2nd trimester

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Oct 20, 2011
Progesterone in 2nd trimester
by: Wray

Hi Brooke I never recommend stopping the progesterone cold turkey, this is enough to cause a miscarriage. It should always be tapered off slowly over a few weeks, or continued throughout the pregnancy. We do have a page on Pregnancy which explains the role it plays and how to use it. Below are the ranges for progesterone during the three trimesters?.
1st trimester 11.2 - 90.0 ng/ml
2nd trimester 25.6 - 89.4 ng/ml
3rd trimester 48.4 - 425 ng/ml
See Medline Progesterone. As you can see, the progesterone doesn't increase in the 2nd trimester. And it could well drop slightly, but I feel the drop you're experiencing is too large, and too fast. I would strongly recommend using the progesterone again, there's no harm in doing this, and potential good, see here. If you find your doctor reluctant to give you the suppositories, don't worry, a progesterone cream is just as effective, and more 'user friendly' too, as it can be applied anywhere and at any time. I've helped many women throughout their pregnancies using a progesterone cream. Please have a vitamin D test done, it's low in most of us and is vital for a successful pregnancy, and the growth of the foetus too, see here, here, here, here and here. These are excellent videos to watch too, see here and here. The minimum daily dose should is 5000iu's per day, and the blood level should be 70-100ng/ml, and not the 30ng/ml doctors and labs regard as adequate. Another nutrient you might consider taking is taurine, also vital for a growing foetus, see here, here and here. Take care Wray

Oct 28, 2011
by: Mariana

Hi There -

This monday that have passed i had a miscarriage at 7weeks... Only to learn i didn't have sufficient Progesterone -- My question: Does this have anything to do with the HCG levels when doing blood test to see if a person is pregnant? Do it correlate? My HCG count were 3400 at 5 weeks - shouldn't the docter have picked it up?

Also do i start using progesterone prior to falling pregnant again, and is it save to use it during pregnancy....

Kind Regards,

Nov 30, 2011
by: Wray

Hi Mariana Your hCG levels were within range, which for 5 weeks are between 18 - 7,340 mIU/m, see here. hCG is the hormone which stimulates the corpus luteum to continue making progesterone after conception. Progesterone levels should have been checked too, as it appears your corpus luteum was not responding to the hCG. I always recommend starting progesterone before conception, and if miscarriages are recurrent, to use it for at least 4 months, if not the entire pregnancy. We do have a page on Pregnancy which explains how to use progesterone. Yes it is safe, progesterone is vital for pregnancy, and the cream is as effective as injections and suppositories for preventing miscarriages, and other adverse symptoms. Before considering it, please see our page on Oestrogen Dominance first as this can occur. Take care Wray

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