Progesterone a day before ovulation

by Lilly Martinez
(Austin, Texas, US)

Hi Wray, so my story goes a little something like this... in June 2011 I missed a cycle had a urine test to see if I was indeed pregnant. I was but my pregnancy didn't progress and I had a miscarriage.

September 19 I believe I had a chemical pregnancy which threw my latest cycle off a couple of days, I have very regular cycles 30 days apart and ovulate 15 days after my cycle has started. I was looking into progesterone and looked up the symptoms of estrogen dominance. Every since I first got pregnant and miscarried I've not been able to lose weight, bad acne, headaches, backaches, water retention and lack of energy.

I started Natpro the 3rd of this month. I thought I ovulated the 2nd but I may have ovulated the 4th. My question is will using Natpro that one day before supposed ovulation keep me from ovulating? I should have taken an ovulation test but didn't. I only used 2.5 mL of Natpro and have been using that dose since.

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Oct 10, 2011
Progesterone a day before ovulation
by: Wray

Hi Lilly Using progesterone one day before ovulation would not stop it. And the amount you are using certainly wouldn't, it has to be at least 200mg/day to prevent it, and started at least a week before ovulation. 2.5ml gives only 83mg progesterone. Interestingly there is a marked increase in the rate at which progesterone rises 12 h before and continues until 12 h after the initiation of the LH surge. It appears in fact that progesterone initiates the LH surge. Although progesterone is normally produced after ovulation, which occurs after the LH surge, this preliminary progesterone surge is produced in the brain, and not the ovaries, see here and here. So using progesterone a day before ovulation is not a bad thing. Another study found that a steeper progesterone rise in the very early days of the luteal phase makes fertilisation more certain, see here. A normal luteal phase lasts 12-14 days, and always occurs the 12-14 days before bleeding. We do have a page on Pregnancy which gives info on how to use progesterone. Take care Wray

Oct 15, 2011
by: Lilly

Cycle should start soon but I'm already having Symptoms of pregnancy. The number one is nausea as soon as I wake up until about 15 minutes after I use the cream and I get headaches then as well. But other than that I feel great. Better than I have felt in a while. My acne I can tell is clearing up. My bloating and water retention is being relieved and I just feel more energized. My question is, as I'm trying to keep this pregnancy if I am indeed pregnant should I automatically up my dose or do it according to symptoms? I've been taking only about 100-150mg a day. I'm almost out so I want to by in bulk. If I'm not pregnant I will still use the cream.

Oct 19, 2011
by: Wray

Hi Lily It does appear you could be pregnant, as the symptoms indicate it, plus your sense of wellbeing. I would recommend upping the amount you use, as I don't believe 100-150mg/day is enough. If you have time to read those papers on the pregnancy page, you'll see levels in excess of 200mg/day are used to prevent a miscarriage. Please consider taking vitamin D, it's vital for the growth of the foetus, see here, here, here, here and here. These are excellent videos to watch too, see here and here. In fact please consider having a test done, it's low in most of us, and is such a vital nutrient. For more info on testing etc see the Vitamin D Council, GrassrootsHealth Birmingham Hospital and Vitamin D Links websites. Another nutrient you could consider taking is taurine, also vital for a growing foetus, see here, here and here. Take care Wray

Feb 26, 2018
I also had progesterone before ovulation
by: Anonymous

I misunderstood the indications in the natural progesterone cream box and started use it at day 8 of my cycle. I have been using 40mg a day (20mg in the morning and 20mg at night). I also have a positive ovulation test at day 11 and day 12, so my LH surge already happened.

Can that amount and number of days using natural progesterone cream stop my ovulation?

Thanks for your answer!

Feb 27, 2018
I also had progesterone before ovulation
by: Joy

That is not enough progesterone. As mentioned on this thread by Wray, between 100-200mg is needed. The amount you are using will aggravate your estrogen receptors. If you have a regular cycle the cream should be used by following your cycle. In other words use during your luteal phase. The How to use Progesterone Cream page explains this in more detail. If your cycle is not regular, the cream should be used every day until your cycle becomes regular. Once this happens use at luteal phase.

Please read these pages.

Estrogen Dominance -

How to use Progesterone Cream -

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