Erectile Disfunction & Progesterone



I'm sure I read on this site that Progesterone would be of help for a man suffering from ED. Am I right ? Would Progesterone cream help with this problem ? My partner uses Serenity Cream as she had a Hysterectomy and in the booklet that comes with the cream also mentions benefits to men ! Could you please help ? Thanks

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Apr 25, 2012
Erectile Disfunction & Progesterone
by: Wray

Hi there Yes it can help, but there are many causes of ED. It depends on what's causing yours, which I take it you don't know, or you wouldn't be asking! As one paper puts it "Penile erection is a hemodynamic process involving increased arterial inflow and restricted venous outflow, coordinated with corpus cavernosum and penile arterial smooth muscle relaxation. Any problem in this mechanism results in Erectile Dysfunction and its etiology is generally multifactorial." It could be one or more of the following, or a combination of them, stress, an unstable blood glucose, diabetes, lack of arginine the precursor to nitric oxide, high blood pressure, a lack of dopamine, radiation or surgery for prostate cancer, psychological, varicocele, hypogonadism, hyperprolactinemia, possibly hyperthyroidism, benign prostatic hyperplasia (BPH), obesity, endothelial dysfunction, heart disease, periodontitis, smoking, epilepsy, impaired adenosine signalling, I could go on, I'm finding it fascinating! See here, here, here, here, here, here, here, here, here, here, here, here, here, here and here. I see I'll have to do a web page on it, we do get men asking about low libido. They don't say if they have ED with it, but the two do tend to go hand in hand. It doesn't appear that a lack of testosterone is implicated in ED, and there is concern about using TRT, there's some info on our page on Man Boobs. Continued below.

Apr 25, 2012
Erectile Disfunction & Progesterone Part 2
by: Wray

Hi there The one thing which stands out amongst all the above is oxidative stress which ultimately leads to Inflammation and tissue destruction. Nitric oxide is vital, it's a vasodilator, ie it causes smooth muscle to relax. The precursor to nitric oxide is the amino acid arginine, a lack of arginine needs to be addressed if it's low. Viagra works on the principle of increasing nitric oxide. Progesterone increases NO, with none of the adverse side effects of viagra. It also relaxes smooth muscle too. A high salt intake suppresses nitric oxide, sugar is detrimental too. In fact it's the most damaging of all 'foods', as it causes glycation. Glycation occurs when a sugar molecule binds to a protein or lipid molecule without the control of an enzyme. This impairs the function of the molecule, leading to advanced glycation endproducts (AGEs), resulting in many of our inflammatory diseases. AGEs cause damage to the vascular lining. Vitamin D prevents the damage AGEs do to vascular endothelial cells, see here. In fact there's increasing evidence a lack of vitamin D is behind diabetes, heart disease, prostate cancer, an unstable blood glucose, high BP, obesity, etc.
Stress causes a cascade of inflammatory cytokines to be produced. Interestingly arginine is a potent antioxidant. One paper points to the recently discovered importance of adenosine in erectile function, it's also a potent vasodilator. It's a nucleoside, and comprises part of the energy molecule ATP. It appears progesterone stimulates it's production, see here. Adenosine, dopamine and nitric oxide are all involved in sleep. Interestingly progesterone reduces erectile dysfunction in sleep deprived rats. Please have a vitamin D test done, you live in the UK where levels are very low. Birmingham Hospital send out test kits for £20, but ignore their 'adequate' level, far too low. For more info on vitamin D levels, etc see the Vitamin D Council and GrassrootsHealth. Blood levels should be 175-250nmol/L and not the 75nmol/L most labs and doctors regard as adequate. Continued below.

Apr 25, 2012
Erectile Disfunction & Progesterone part 3
by: Wray

Hi there The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Finally we do have a few comments from men you might like to see here, here here, here, here, here and here. I recommend 10-100mg/day progesterone for men, although we do have one using 400-600mg/day for stress. Take care Wray

Sep 12, 2014
cream vs pills
by: erin

I am taking progesterone pills as I find the cream a bit if a hassle. Is their a problem with this.

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