by Anita
(Mesa, AZ)

I was wondering if anyone else has a problem with liver dysfunction when trying to take higher doses of progesterone cream? I get pain and tightness in my chest, liver and gallbladder when trying to use more than 100mg of cream.

My first experience with progesterone was the oral pill and I would throw it up as soon as swallowing so my doctor switched me to the cream. I have never been able to use more than 100 mg without developing nausea and then severe pain. I am having lots of symptoms of estrogen dominance now and would like to figure out how I can tolerate higher doses.

I have had an ultrasound of my liver to rule out liver disease and I was told it looked fine. I do have very low cholesterol of 130 and I do everything I cant to increase it, but with little results.

What can I do? Do these types of symptoms go away on higher doses?

Comments for Anita

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Jan 11, 2018
by: Joy

Hi Anita

I have not heard of progesterone affecting the liver or gallbladder, but chest pains are usually caused by not using enough progesterone, excess estrogen causes it. If you feel that 100mg is all that you can manage then stick with that amount, it will just take longer for those horrid estrogen dominance symptoms to clear. I feel that your body is adjusting which can take between 2-6 months. As we are all different, progesterone therapy can affect one in different ways.

How to use Progesterone Cream -

Estrogen Dominance -

Jan 11, 2018
Nausea on progesterone
by: Rachel

Hi there!
Have you had your hormones tested? I ask because I was convinced I was estrogen dominant when in fact I wasn’t at all. I cannot think of a reason why progesterone makes you feel sick! Hopefully someone else can help.

I hope you feel better soon. My cholesterol is also very low and I eat lots of good fats!

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