Ratio between Oestrogen and Progesterone Clarification
I found your site some months ago after years of baffling and at times distressing symptoms, health issues, etc. Among them 2 blighted ovums, 2 miscarriages, monthly migraines, ludicrous weight gain, tiredness, oedema, eyebrows disappearing, recurrent infections ( including hospitalisation with septicemia last year!!) etc etc.
I started on NatPro in May of this year after reading your site top to bottom and back to front. I use around 320 ml for 2 weeks of my cycle ( still almost regular 28 day cycles...occasionally slightly shorter). My migraines disappeared from the second month - WONDERFUL!! My husband says I no-longer snore (!) and the large, so-called liver spot that had appeared above my left eye a couple of years ago has now miraculously disappeared.
Unfortunately the weight hasn't changed unfortunately ( has continued to creep up) and I feel that my thyroid is suffering more than it has done previously - I feel pain in my neck and throat far more frequently than ever. I don't put this down to progesterone btw...The fatigue is also worse. I am often in bed by 9pm. And that's with an afternoon nap!
I would like a little advice if you have a moment. I am 48 by the way, and eat well - organic produce, a keen cook so no processed food and rigorous about nutritional balance. And it's the usual story of 1,500 calories and no more, plus yoga, walking and weights simply to maintain my weight at 2 stone more than it should be.
VitD tested in 2013 -81 nmol/L; Vit B 551 pmol/L.
I had blood tests done 2 weeks ago. The endocrinologist tells me everything is ''absolutely fine'' except elevated liver enzymes. In fact, antibodies and ultrasound revealed (moderate) Hashimotos disease - though she said this was nothing to worry about and couldn't possibly explain any of the symptoms I presented to her. (!!)
My hormone results were also intriguing and are as follows:
Estradiol E2 571 pmol/L
Progesterone 1.9 nmol/L (1900? pmol/L)
Testosterone 1.9 nmol/L
Am I right in my calculations that the ration P:E is about 3.3:1? Of course, they results are in range which is why the endo did no-more than glance at them before declaring them ''fine''.
If my calculation is correct, this is very, very low. Should I increase the NatPro to 400-500 a day? Use it every day of my cycle?
My liver enzyme result does concern me - I will start with Milk Thistle very soon and have cut out alcohol and reduced coffee/tea to one a day. If I understand things correctly, a sluggish liver will struggle to get rid of the oestrogen that is dumped there. And of course the Hashimotos is also a factor.
I cannot understand if the ratio of testosterone to oestrogen is significant in my case?
Any advice very gratefully received Wray and thank you very much for such a wonderful site.