Please help understand lab results

by Katie


I have always suspected that I am estrogen dominant, because of constant breast-swelling before my cycle, and severe migraines on day 1 or day 3 of my menstruation.

I supplemented with natural progesterone cream (just for one cycle) and the migraine during those menses put me in bed for 2 days. So I was afraid to try progesterone again, until I got my saliva test done. I received my results, and even though the report says I am estrogen dominant, I am not sure how to understand the numbers, and how much, if any, progesterone should I use.

My estradiol results are - 22,70 pg/ml

My proesterone results are - 165 pg/ml

Hormone ratios Pg/E2 7,3:1

Can you please help me understand what that means, and how much progesterone should I use? Was progesterone the reason I had a very severe migraine the last cycle? I always have a bad migraine, but this was something else.

Thank you

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Nov 20, 2020
Please help understand lab results
by: Joy

Hi Katie

The actual cause of Migraines is unknown. However, it does appear as if hormones could be the cause in many women. Try rubbing progesterone cream at the back of your neck, it should help with the pain as progesterone is an excellent anti-inflammatory.

When first using progesterone and can make adverse symptoms worse especially if not enough progesterone is used. Progesterone therapy takes time and patience, it is not an overnight fix. It can take 2 - 6 months before positive results are felt. Please read the How to use Progesterone Cream and Estrogen Dominance pages for more information. Between 100-200mg progesterone is needed per day, more if symptoms are severe. Use half the amount in the morning and the other half at night, never use it just once a day.

You test results show that your progesterone:estrogen ratio is 7:1, it should be around 600:1. You certainly need more progesterone. The Hormone Testing page explains in more detail.

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