P:E ratio still low, low testosterone.

by Mirelle


i 25 years old and am taking 400 mg of Progesterone since 8 months and a lot of my many symptoms improved but I also didn't have a period since beginning therapy.

Last month I ordered a blood test and My results were: Progesterone: 11.40 ng/ml
Estradiol: 231 pg/ml
Testosterone 0.129 ng/ml

I calculated a P:E ratio of 1:49.

My estrogen is pretty high and my doc told me that I should get a period soon which I know I don't and it didn't happen.

Testosterone is too low.

Progesterone is quite normal but I don't know my cycle because I don't have one.

So basically my estrogen rose quite significantly an my T dropped rapidly.

Before therapy I had less of every hormone especially really low estrogen and the same P:G ratio.

What is going on?

Comments for P:E ratio still low, low testosterone.

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Jan 31, 2023
P:E ratio still low, low testosterone.
by: Joy

Hi Mirelle

After 8 months of using progesterone things should have settle down. Something is going on here. What is your Vitamin D3 level? A deficiency reduces the benefits of progesterone, cofactors are needed. Are you using progesterone correctly? The amount used should be split in two or more, morning and again at night or can be split over the course of the day. Please read How to use Progesterone Cream. Does your progesterone cream equate to that of Natpro which is a 3% cream, or are you using Natpro? 400mg Progesterone can be used to delay periods. It is often an amount that is recommended for severe symptoms and to stop heavy bleeding.

Your progesterone:estrogen ratio is actually 49:1, it should be around 600:1 before benefits are felt. It annoys me when told that tests or "low/high/normal/fine". What exactly does it all mean? I suggest asking for your test results and compare them to the correct results as per the Hormone Testing page.

If you are wanting your period to come on, then you could slowly reduce the amount however, you are deficient in progesterone. You could either stick with the 400mg until your period comes or reduce. If you reduce it will take longer for progesterone to become dominance which is what you want. You will have to decide which option suits you best.

I hope this helps.

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