I see no point in pregnenolone, as it has to be converted into progesterone, but it is converted into DHEA too, which no woman needs more of. See here and here. The Steroidogenic Pathways explains in detail.
Jun 14, 2019
Prenenolone by: To
Thank you for your reply. I'm a man, so same thoughts? Is there more of a chance of DHEA turning into estrogen?
Jun 21, 2019
Pregnenalone Not Needed by: Susan in Oakville
When adrenal fatigue is present, and cortisol is low in the body...supplemental Pregnenalone will convert to cortisol production NOT progesterone in the body. So you would end up with no improvement in progesterone levels. This is called the pregnenalone steal!
Dec 03, 2020
Preglenelone steal by: Stef
This is what’s happening to me I believe! I have adrenal fatigue and lots of estrogen dominance. I feel a anxious while on 200mg cream. I am afraid to up my dose to find relief because I’m afraid it will make more cortisol. What do I do should I stop progesteone. I know I’m low I’m progestrone and also have high estrone levels and will benefit from the cream but I’m having anxiety and also insomnia at times on it! I’m desperate for any help thank you!
Mar 08, 2021
Pregnenolone steal by: Anonymous
Hey I have the same issue right now lol I have low progesterone and I been taking 100mg for 3 days and have had insomnia and jitteriness at night I’m wondering if I should maybe wait a few weeks or so and try a much higher dose did u ever find a solution to ur problem?
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Although this web site is not intended to be prescriptive, it is intended, and hoped, that it will induce in you a sufficient level of scepticism about some health care practices to impel you to seek out medical advice that is not captive to purely commercial interests, or blinded by academic and institutional hubris. You are encouraged to refer any health problem to a health care practitioner and, in reference to any information contained in this web site, preferably one with specific knowledge of progesterone therapy.