What about blood clots?

by Kristi

Thank you so much for all the information on PCOS. I really enjoyed reading! I have been on spironolactone for 12 years. Recent studies say that long term use can cause tumors. My doctor reduced my dose by half, after some begging.

I started Progesterone Cream a month ago... I tried to talk to my gynecologist about dosing; she wouldn't comment because it's not FDA approved. I continued on with about 45mgs + spironolactone. I feel so good. I feel like myself again! :-D Today I went to my family doctor and talked to him about the progesterone cream. He told me that he can't recommend it because studies aren't done properly (20%-30% is just placebo); it causes blood clots; and it hasn’t been proven to actually do anything. I know that he is wrong about the fact that it doesn’t do anything!! What about blood clots? I read on a few sites that there are no side effects. My body needs this cream badly!! I feel a little apprehensive about using it now. Is there any truth to this?

I also have a question about my mother. She had a hysterectomy 10 years ago. She’s been on Premarin. She wants to quit and start estrogen cream. Should she be using progesterone also?

Thanks again for all the information!

Comments for What about blood clots?

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May 17, 2010
Blood Clots
by: Anonymous

I am on bio-identical progesterone - prescribed by my doctor. I have done a lot of research and not read anything that I can recall about blood clots. I take it all month long because I am so deficient. As for your mom, I would think it best if she has a good doctor help her make that transition. I definitely would encourage her to switch to a bio-identical form of supplement. The synthetic stuff is not good for our bodies.

May 18, 2010
What about blood clots?
by: Wray

Hi Kristi. I'm pleased the info on PCO helped. I don't believe you need spironolactone. It's obviously not solved the problem. It's a diuretic and anti androgen. Progesterone is the best diuretic there is. It's given to brain trauma victims via IV transfusion, to prevent the oedema and inflammation that occurs due to the injury. Prior to it's use 50 drugs had been tried unsuccessfully, the study also found it prevented deaths and the disability ratings. Please see here. And here. I feel you should come off the spironolactone, it's not a safe drug. Please see here. Progesterone also suppresses excess testosterone. Progesterone is FDA approved, every fertility clinic uses it either as injections or suppositories. It matters not how it's delivered, apart from the oral varieties, as oral progesterone is mostly destroyed passing through the gut and liver. Please see here. And here. I think you'll find these studies were done 'properly'! Incidentally 20-30% placebo affect occurs with drugs too. And far from causing clots, the reverse in fact, oestrogen does, but not progesterone. It prevents platelets aggregating, as it reduces thrombin, the clotting factor, by 10-15%, please see here. And here. It also prevents atherosclerosis, please see here. And here. It's a pity so little is known about progesterone by the medical profession. Thousands of studies have been done on it. Have a vitamin D test. 50% of us are deficient in it, and it plays a huge role in preventing PCO. Incidentally another study found a low level reduced the benefits of progesterone. You also need large amounts of other antioxidants too. PCO is caused by oxidative stress. I'm pleased your mother wants to come off the Premarin, here's info on it. Oestrogen will do the same, even in a cream form. Far safer if she used only progesterone. Take care, Wray

Feb 17, 2016
Progesterone Use
by: terri

I had Blood Clot in Left Leg when I was in my 30's and on Birth Control Pills. I am 61 yrs old Now. I had Blood Test to Determine if I was Negative or Positive to get Blood clots. My Test was postivie. Im Not able to Use Estergon, Is it Safe for me to Use Progesterone? What dose should I use. I Feel Miserable All the Time, I need Hormones!!! Help

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