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What about blood clots?

by Kristi

Thank you so much for all the information on PCOS. I really enjoyed reading! I have been on spironolactone for 12 years. Recent studies say that long term use can cause tumors. My doctor reduced my dose by half, after some begging.

I started Progesterone Cream a month ago... I tried to talk to my gynecologist about dosing; she wouldn't comment because it's not FDA approved. I continued on with about 45mgs + spironolactone. I feel so good. I feel like myself again! :-D Today I went to my family doctor and talked to him about the progesterone cream. He told me that he can't recommend it because studies aren't done properly (20%-30% is just placebo); it causes blood clots; and it hasn’t been proven to actually do anything. I know that he is wrong about the fact that it doesn’t do anything!! What about blood clots? I read on a few sites that there are no side effects. My body needs this cream badly!! I feel a little apprehensive about using it now. Is there any truth to this?

I also have a question about my mother. She had a hysterectomy 10 years ago. She’s been on Premarin. She wants to quit and start estrogen cream. Should she be using progesterone also?

Thanks again for all the information!

Comments for What about blood clots?

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May 17, 2010
 Blood Clots
by: Anonymous

I am on bio-identical progesterone - prescribed by my doctor. I have done a lot of research and not read anything that I can recall about blood clots. I take it all month long because I am so deficient. As for your mom, I would think it best if she has a good doctor help her make that transition. I definitely would encourage her to switch to a bio-identical form of supplement. The synthetic stuff is not good for our bodies.
May 18, 2010
 What about blood clots?
by: Wray

Hi Kristi. I'm pleased the info on PCO helped. I don't believe you need spironolactone. It's obviously not solved the problem. It's a diuretic and anti androgen. Progesterone is the best diuretic there is. It's given to brain trauma victims via IV transfusion, to prevent the oedema and inflammation that occurs due to the injury. Prior to it's use 50 drugs had been tried unsuccessfully, the study also found it prevented deaths and the disability ratings. Please see here. And here. I feel you should come off the spironolactone, it's not a safe drug. Please see here. Progesterone also suppresses excess testosterone. Progesterone is FDA approved, every fertility clinic uses it either as injections or suppositories. It matters not how it's delivered, apart from the oral varieties, as oral progesterone is mostly destroyed passing through the gut and liver. Please see here. And here. I think you'll find these studies were done 'properly'! Incidentally 20-30% placebo affect occurs with drugs too. And far from causing clots, the reverse in fact, oestrogen does, but not progesterone. It prevents platelets aggregating, as it reduces thrombin, the clotting factor, by 10-15%, please see here. And here. It also prevents atherosclerosis, please see here. And here. It's a pity so little is known about progesterone by the medical profession. Thousands of studies have been done on it. Have a vitamin D test. 50% of us are deficient in it, and it plays a huge role in preventing PCO. Incidentally another study found a low level reduced the benefits of progesterone. You also need large amounts of other antioxidants too. PCO is caused by oxidative stress. I'm pleased your mother wants to come off the Premarin, here's info on it. Oestrogen will do the same, even in a cream form. Far safer if she used only progesterone. Take care, Wray
Feb 17, 2016
 Progesterone Use
by: terri

I had Blood Clot in Left Leg when I was in my 30's and on Birth Control Pills. I am 61 yrs old Now. I had Blood Test to Determine if I was Negative or Positive to get Blood clots. My Test was postivie. Im Not able to Use Estergon, Is it Safe for me to Use Progesterone? What dose should I use. I Feel Miserable All the Time, I need Hormones!!! Help
Apr 24, 2018
 Blood Clots and Hormones
by: Jamie

I am 60 years old and had a hysterectomy and both ovaries removed. I had surgery 10 years ago and got blood clots in my lungs and legs. I had recently lost a son, flown out of the country and had walking pneumonia a few months before the surgery so the doctors felt this led to the blood clots.

I desperately need hormones but my doctor is reluctant because of the clots. Is it definitely out of the question to take progesterone after having one episode of blood clots. I don't know where to turn to get help?

I would appreciate any guidance.
Apr 25, 2018
 What about blood clots?
by: Joy

Hi Jamie

Wray has explained further up on this thread about progesterone and clots. Your doctor is correct in not wanting you to take HRT (drugs). However, natural progesterone is safe. It doesn't cause clots, whether in the uterus or the blood. It prevents platelets aggregating, reduces thrombin by about 15%, so reducing clotting, it prevents lipid peroxidation and atherosclerosis. Perhaps you can mention this to your doctor?
See: https://www.ncbi.nlm.nih.gov/pubmed?cmd=Retrieve&db=PubMed&list_uids=17217322&dopt=Citation

If you do decide to use a good natural progesterone cream such as Natpro, please use 100-200mg per day.

Please read these pages.

How to use Progesterone Cream - https://www.progesteronetherapy.com/how-to-use-progesterone-cream.html

Estrogen Dominance - https://www.progesteronetherapy.com/estrogen-dominance.html

Menopause - https://www.progesteronetherapy.com/menopause.html
Oct 13, 2022
 regarding progesterone bio identical.
by: Anonymous

I have had a DVT and I have been on Prometrium (brand name only) bio identical progesterone for about 20 yrs. I have chronic vein issues due to the DVT.
I hemorrhaged from the blood thinners I was on due to the blood clot and doctors did not know how to tend to me. They were going to put me on a progestin. That is the synthetic. Luckily I have a sister and a mother who are nurses and they would not allow me to be put on them.
Prometrium-bioidentical progesterone is not what causes blood clots. In fact it help to normalize blood clotting issues. It is the synthetic hormones in particular estrogen that cause clotting.

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