Two miscarriages

by Molly
(MN)

I conceived once, have a healthy two year old and am now trying again but have suffered 2 miscarriages in a row.

My husband and I started trying to conceive and we were pregnant the second month of trying. We were devastated when I started to miscarry at 6 weeks. I had an ultrasound and the miscarriage was confirmed. The midwife told us to wait 2 cycles to try again and we waited.

The first month we could try we got a "pregnant" on a digital pregnancy test... we were thrilled, only to have the bleeding to start again the next day. I went to my clinic to get a Beta Hcg. The results were not good - 6.5. I go back to tomorrow for another beta.

My midwife thinks I may have a progesterone deficiency since I get pregnant very easily, I just cannot sustain the pregnancy. I go back to the doctor in 2 weeks to hopefully get labs done to find out if this is my problem. I hope to experience the most beautiful gift in the world again with treatment.

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Two miscarriages

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Nov 03, 2008

Two miscarriages
by: Wray

Hi Molly, I think your midwife is correct, it does sound very much as if you have a progesterone deficiency. Usually conception is not a problem, particularly if you've already had a child, but if the corpus luteum does not make enough progesterone to sustain the embryo, you will miscarry. This most commonly occurs in the first 6-8 weeks.

The lab test might not show you have a deficiency, as it's only occurring when you're pregnant. You might find the mini microscope more helpful than the pregnancy test, these are not very accurate, as the Hcg needs to be quite high before it's detected on a home kit.

See: http://en.wikipedia.org/wiki/Pregnancy_test

We do have a web page on conception and pregnancy you might like to look at:

http://www.progesteronetherapy.com/faq-conception.html

It gives all the info you need on how to use the progesterone from ovulation to it's use in pregnancy. I would also follow the good advice from your midwife, and have a break again of about 2 months before trying again. I do hope you get your wish! Take care Wray

May 26, 2009

Two miscarriages too
by: Andrea

Hi Wray, I just had my 2nd consecutive misscariage in about 6 months. I misscarried very early for both pregnancies like before 4-6 weeks. I also have a 1.5 year old. I am 34 and I think progesterone levels may be the issue. I was prescribed an oral progesterone pill that is natural not synthetic that I am told to start taking as soon as I have a positive pregnancy test. I would like to know if anyone out there has had any luck with progesterone and healthy deliveries.

May 29, 2009

Two miscarriages too
by: Wray

Hi Andrea. It very much sounds as if it could be a low progesterone issue. Oral progesterone is not very affective, the better delivery systems are injections (painful!), suppositories or creams. I prefer the cream as it's more versatile as you can apply it where ever it's needed.

"Orally administered progesterone is rapidly metabolized in the gastrointestinal tract and its use has proved to be inferior to i.m. and vaginal routes. Progesterone i.m. achieves serum progesterone values that are within the range of luteal phase and results in sufficient secretory transformation of the endometrium and satisfactory pregnancy rates. The comparison between i.m. and vaginal progesterone has led to controversial results as regards the superiority of one or the other in inducing secretory endometrial transformation. However, there is increasing evidence in the literature to favour the use of vaginal progesterone."

And:
"Progesterone can be delivered orally, intramuscularly and vaginally. The oral route is the least efficient but the intramuscular route is as efficient as the vaginal route"

And:
"However, antiproliferative effects on the endometrium have been demonstrated with progesterone creams when circulating levels of progesterone are low. Thus, effects of topical progesterone creams on the endometrium should not be based on serum progesterone levels, but on histologic examination of the endometrium."

I would recommend you switch to a cream or suppositories. I am currently helping a few women who've have miscarriages and who are now pregnant and using progesterone. I've also helped those who have now had their babies and were also using progesterone! Please see our web page here on pregnancy for more info.

Take care, Wray.

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May 29, 2009
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Submitted by: Wray

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Hi Andrea. It very much sounds as if it could be a low progesterone issue. Oral progesterone is not very affective, the better delivery systems are injections (painful!), suppositories or creams. I prefer the cream as it's more versatile as you can apply it where ever it's needed. "Orally administered progesterone is rapidly metabolized in the gastrointestinal tract and its use has proved to be inferior to i.m. and vaginal routes. Progesterone i.m. achieves serum progesterone values that are within the range of luteal phase and results in sufficient secretory transformation of the endometrium and satisfactory pregnancy rates. The comparison between i.m. and vaginal progesterone has led to controversial results as regards the superiority of one or the other in inducing secretory endometrial transformation. However, there is increasing evidence <a href="http://humupd.oxfordjournals.org/cgi/content/abstract/6/2/139">in the literature to favour the use of vaginal progesterone."</a> And: "Progesterone can be delivered orally, intramuscularly and vaginally. The oral route is the least efficient but the intramuscular route is <a href="http://www.future-drugs.com/doi/abs/10.1586/17474108.1.2.173?cookieSet=1&journalCode=eog">as efficient as the vaginal route"</a> And: "However, antiproliferative effects on the endometrium have been demonstrated with progesterone creams when circulating levels of progesterone are low. Thus, effects of topical progesterone creams on the endometrium should not be based on serum progesterone levels, <a href="http://www.menopausejournal.com/pt/re/menopause/abstract.00042192-200512020-00019.htm;jsessionid=G9vQGJ2FjtWkN4jXHSTKWdhfsgHhvxNMQ42LYWnHvhH1rXz7HjTG!-1465501618!-949856144!8091!-1">but on histologic examination of the endometrium."</a> I would recommend you switch to a cream or suppositories. I am currently helping a few women who've have miscarriages and who are now pregnant and using progesterone. I've also helped those who have now had their babies and were also using progesterone! Please <a href="http://www.progesteronetherapy.com/faq-conception.html">see our web page here</a> on pregnancy for more info. Take care, Wray.

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Mar 04, 2010

I'm unsure
by: Kayla

I just experienced my 2nd consecutive miscarriage in almost a year. They both ended at 19 weeks exactly. With the first I thought that it was my husband and my fault only because we were having sex when my water broke. There was no pain, no blood, just this big gush of clear fluid running down my leg. I have never been so scared in my life until a couple weeks ago when I was walking into my mother's kitchen. At 19 weeks it happened again, my membranes pre-ruptured. This time around there was blood maybe 20 minutes later, but no pain. But like the first the doctors said they couldnt do anything and the cord prolapsed much earlier than the first time. They're going to run a test in a few weeks on my uterus and hopefully I get the autopsy report from my son saying that there may of or may not was an abnormality. Right now I'm just scared of whatever the doctors are going to say because besides them saying there were no infections, or it wasnt our fault we are in complete darkness right now. I'm 23 years old and I can not bring a healthy full term child into this world and no one can tell me why, and it hurts. I just would like to know something.

Mar 04, 2010

I'm unsure
by: Wray

Hi Kayla. It is difficult to say why it's happening, it could be you also need progesterone. Although miscarriages are more common in the first 6-8 weeks, they can occur later, as can pre-term births. Progesterone is also administered then. Please read this web page, it might give you more insight into pregnancy. Take care, Wray

Mar 09, 2010

2 miscarriages
by: Anonymous

2 years ago I met a very handsome man. 2 months into the relationship I found out that I was prego... What a surprise! I was scared, happy, worried, in love with this little person. I went to the DR because I started to bleed. They told me that everything was "OK" and that I was 6 weeks along. Well the bleeding got harder and harder. Me never have been prego before thought that maybe it was normal because everyone that I talked to even the DR said I would know if I was losing my baby. I went to a different DR 2 weeks later and found out that I lost the baby. A year and a half went by and I became prego again. I was so happy! I wanted this baby more than anything. I was ready to beome a mom and my husband was ready to become a dad again. I didn't want anyting to go wrong with this one so I started my prenads right away. I got my DR appointment right away. I was ready. Well we went to the DR and we found out that the baby was 6 week and 5 day old. We watched "yolkie" baby heart beat. We were told that even though I had a miscarriage he told me I was a low risk and I had nothing to worry about. On my birthday I was 10 weeks and 2 days along. I went to the ER because I started to bleed and I found out that the babys heart stopped beating at 8 weeks and 5 days. I was destroyed! I loved that little baby more than anyting. I wanted it more than I have ever wanted anything. My DR told me that I could start trying after my next cycle. And I will be. I will have a very hard time with conception because I have opcs. But we will try again, and hope for the best but I will never go to that DR again. So to all you out there that have had this don't give up keep trying. I know I won't till I become a mom

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Mar 09, 2010
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Submitted by: Anonymous

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2 years ago I met a very handsome man. 2 months into the relationship I found out that I was prego... What a surprise! I was scared, happy, worried, in love with this little person. I went to the DR because I started to bleed. They told me that everything was "OK" and that I was 6 weeks along. Well the bleeding got harder and harder. Me never have been prego before thought that maybe it was normal because everyone that I talked to even the DR said I would know if I was losing my baby. I went to a different DR 2 weeks later and found out that I lost the baby. A year and a half went by and I became prego again. I was so happy! I wanted this baby more than anything. I was ready to beome a mom and my husband was ready to become a dad again. I didn't want anyting to go wrong with this one so I started my prenads right away. I got my DR appointment right away. I was ready. Well we went to the DR and we found out that the baby was 6 week and 5 day old. We watched "yolkie" baby heart beat. We were told that even though I had a miscarriage he told me I was a low risk and I had nothing to worry about. On my birthday I was 10 weeks and 2 days along. I went to the ER because I started to bleed and I found out that the babys heart stopped beating at 8 weeks and 5 days. I was destroyed! I loved that little baby more than anyting. I wanted it more than I have ever wanted anything. My DR told me that I could start trying after my next cycle. And I will be. I will have a very hard time with conception because I have opcs. But we will try again, and hope for the best but I will never go to that DR again. So to all you out there that have had this don't give up keep trying. I know I won't till I become a mom

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Jul 29, 2010

2 miscarriages and on progestorone
by: Anonymous

It's comforting to know I am not out there alone. I have a healthy beautiful 2 1/2 year old daughter. We had no issues in the pregnancy with her and everything went perfect. My husband and I decided to start trying again for a second child and had a missed miscarriage the first time at 7 weeks and a blighted ovum at 8 weeks. My doctor has just prescribed me a vaginal progestorone that I need to take as soon as I get pregnant again. I am torn on whether or not to start trying because I don't want to have to live thorough another dissapointment and D&C. Is there anyone out there who went through this and was put on progesterone that ended up with a baby?