Transexual and Progesterone useage

by Stefanie
(Durban, South Africa)

I am a post transitioned male to female transexual. I commenced HRT 18 months ago and take 6mg of Estrofem orally daily. Plus prior to my sex reasignment surgery was also taking anti androgen also. This was stopped just prior to my surgery in March.

Somebody told me that I should be taking Progesterone as part of my HRT along with the Estrofem. Would love to know what you think.

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Transexual and Progesterone useage

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May 08, 2010

Transexual and Progesterone useage
by: Wray

Hi Stefanie. Yes you should be! That dose of oestrogen is too high, and without progesterone you are liable to get clots forming. The following is from a case similar to yours:

"decided to go through the surgery.....started with being on spironolactone for the first year to reduce testosterone....the second year on 2.5 mg of estrogen with spironolactone. The third year the dose of estrogen went up to 6.5 mg per day....6 months later had my first blood clot in calf. Then in the hospital on a heparin drip and off estrogen for a year....went back on estrogen at 2.5 mg per day plus aspirin to keep my blood from clotting. After surgery stopped the spironolactone and premarin dose went down to 0.5 mg per day. Three weeks later in the hospital with a pulmonary embolism and on a super industrial strength blood thinner, after that the doctor refused to put me back on premarin or any other estrogen supplement. Then my health went down hill....cholesterol shot up.....put me on 10 mg of Lipitor......then raised the dose of Lipitor to 20 mg and 30 mg of Flexarill per day for the muscle spasms... then constipation medicine....then a high blood pressure medicine...then meds to help sleep at night and wake up in the morning and anti-depressants, etc., etc., etc.. weighed 338 lbs....health continued to destabilize.....diagnosed with degenerative disc in my back, fibromyalgia, tremors, insomnia, severe depression."

Not a pleasant story to read, all of which could have been prevented by giving her progesterone. Progesterone must always be given to counteract the oestrogen, this causes clots, progesterone reduces thrombin by 10-15% so preventing them. It also prevents atherogenesis because it stops blood fats from oxidising. Yes you do need oestrogen but nowhere near the dose you are on. Far safer to have a low one, no biological woman makes anywhere near that amount either! Oestrogen stimulates fat cells and other hormonally sensitive tissue, one affect is causing a thicker fatty layer to be deposited than men have, plus forming breasts. I can't get my head around why women after transexual surgery are given such high doses of oestrogen. So yes I think you do need progesterone, as for the amount I suggest you try about 100mg/day and see if that helps. You will probably get symptoms of oestrogen excess, being on such a high dose, so please see here. Take care, Wray

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May 08, 2010
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Submitted by: Wray

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Hi Stefanie. Yes you should be! That dose of oestrogen is too high, and without progesterone you are liable to get clots forming. The following is from a case similar to yours: "decided to go through the surgery.....started with being on spironolactone for the first year to reduce testosterone....the second year on 2.5 mg of estrogen with spironolactone. The third year the dose of estrogen went up to 6.5 mg per day....6 months later had my first blood clot in calf. Then in the hospital on a heparin drip and off estrogen for a year....went back on estrogen at 2.5 mg per day plus aspirin to keep my blood from clotting. After surgery stopped the spironolactone and premarin dose went down to 0.5 mg per day. Three weeks later in the hospital with a pulmonary embolism and on a super industrial strength blood thinner, after that the doctor refused to put me back on premarin or any other estrogen supplement. Then my health went down hill....cholesterol shot up.....put me on 10 mg of Lipitor......then raised the dose of Lipitor to 20 mg and 30 mg of Flexarill per day for the muscle spasms... then constipation medicine....then a high blood pressure medicine...then meds to help sleep at night and wake up in the morning and anti-depressants, etc., etc., etc.. weighed 338 lbs....health continued to destabilize.....diagnosed with degenerative disc in my back, fibromyalgia, tremors, insomnia, severe depression." Not a pleasant story to read, all of which could have been prevented by giving her progesterone. Progesterone must always be given to counteract the oestrogen, this causes clots, progesterone reduces thrombin by 10-15% so preventing them. It also prevents atherogenesis because it stops blood fats from oxidising. Yes you do need oestrogen but nowhere near the dose you are on. Far safer to have a low one, no biological woman makes anywhere near that amount either! Oestrogen stimulates fat cells and other hormonally sensitive tissue, one affect is causing a thicker fatty layer to be deposited than men have, plus forming breasts. I can't get my head around why women after transexual surgery are given such high doses of oestrogen. So yes I think you do need progesterone, as for the amount I suggest you try about 100mg/day and see if that helps. You will probably get symptoms of oestrogen excess, being on such a high dose, <a href="http://www.progesteronetherapy.com/estrogen-dominance.html" target="_blank">so please see here.</a> Take care, Wray

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