stigmasterol

As I research, it looks like the main base for Natpro is derived from soy. One of your responses indicates that there is no soy, only yam, yet it is also stated on a page that Natpro is not a yam "extract." Could you please clarify?

Comments for stigmasterol

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Oct 16, 2012
stigmasterol
by: Wray

Hi there Sorry about the confusion. We used to use a non GM soy based progesterone, but due to much confusion, we changed to a yam based progesterone. The confusion arose because people assume being made from soy means there's actual soy in the cream. No amount of reasoning on my part could persuade them there cannot be soy in it. None of the worldwide certification bodies would give a certificate saying it was progesterone if contaminated by soy. Ironically none of the pharmaceutical firms making progesterone injections or suppositories for use in IVF treatments, miscarriages or pre-term births, mention where the progesterone comes from. It only seems to be the creams people are concerned about. Progesterone is not extracted from plants, the precursor is. Plants such as the soy bean, Dioscorea species of yams, fenugreek, sisal, calabar bean, some lilies, yucca, some solanum species, maize and many more contain phytosterols. Some of which are stigmasterol, diosgenin, beta-sitosterol, campesterol, hecogenin, sarsasapogenin, solasodine. As these plant sterols have a similar molecular structure to cholesterol, they are used as starting points for the synthesis of progesterone. Cholesterol is the starting point for the steroid hormones made naturally in animals, including humans. Take care Wray

Oct 16, 2012
vit D and progesterone
by: Anonymous

This makes sense. Thank you for the clarification.
Thanks for the wealth of information as well. I have ordered my first bottle of the progesterone cream and am looking forward to some relief. I have taken other info from your website and found that taking vitamin D along with calcium and magnesium has had a beneficial effect on the heaviness of this lengthy flow I have had recently. I have had a problem with not getting enough sun since I moved to Washington state 10 years ago but thought I was just being a whiny California girl. It seems that it was legitimate. I have been missing vit D that I had so easily gotten.

Oct 17, 2012
vit D and progesterone
by: Wray

Hi there Pleased it made sense! I do hope the progesterone helps you, it is trial and error. One size does not fit all, and many things can cause the level to fluctuate too. Stress being a major factor, plus a lack of vitamin D. And no you are not a whiny California girl! Vitamin D is vital and all the northern states don't get enough sun. And further north of course in Canada it's even worse. Progesterone and Vitamin D work synergistically, and a low level of vitamin D reduces the benefits of progesterone. Magnesium is the most important co-factor for vitamin D, but often calcium is not needed. One of the roles vitamin D plays is drawing calcium from the gut, we tend to have more calcium in our diets than magnesium, which is often low in the States, due to low levels in the soil. So I would suggest you take the magnesium and not the calcium. Excess free calcium in the blood results in depression, calcified arteries and heart disease, see here, here, here, here and here. If you have heavy bleeding, please consider taking at least 2000mg/day NAC (N-acetyl cysteine), at least 5000iu's vitamin D, 2000mg/day taurine, another powerful antioxidant, low levels have been found in women with dysfunctional uterine bleeding, and about 200mg/day progesterone. You might need more, as I've found 400mg/day is usually needed. There's more info about this on our Menstruation page. This is a very long page here, I don't expect you to read it all, but scroll down to 'Sep 26, 2012 update on heavy bleeding, pt 1', Susie M gives a list of the nutrients and the amounts she was taking to stop her bleeding. Thanks for the kind words about the site! Take care Wray

May 03, 2013
beta-sitosterol and Campesterol -- making progesterone?
by: Anonymous

To Wray,

You said that beta-sitosterol and campesterol are starting material for synthesis of progesterone. Can you be so kind to show the source?

As far as I know, Stimasterol can be starting material by bio-means. But it is not clear how beta-sitosterol and campesterol can also be used for that purpose.


May 05, 2013
beta-sitosterol and Campesterol -- making progesterone?
by: Wray

Hi there I was giving examples of phytosterols that could be used in the conversion to progesterone. It really depends on the economic viability of the plant sterol. Stigmasterol and diosgenin are generally preferred as they are usually found in higher concentrations. This patent here shows the bioconversion of numerous sterol substrates. This paper here shows the biosynthetic route for making hydrocortisone using yeast. From ergosterol to campesterol, to pregnenolone, to progesterone, to 17-hydroxyprogesterone to 11-deoxycortisol. The reaction can be stopped at any point along this line. Take care Wray

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