Should I use more progesterone?

by Louise Latham-Pugh
(England, UK)

I am 8 weeks pregnant. I have 2 children who are 7 and 9. We decided to try for another baby 3 years ago and after many attempts we resorted to IVF last summer (July 2010). I fell pregnant with twins and lost one at 6 weeks and the other at 9 weeks and 5 days.

I had some embryos in the freezer so I had two put back in January 2011. Only one took which is the one I am carrying now. I have been constantly monitored and my progesterone at 5 weeks was 40 then it dropped to 29 so I was quickly put onto Progesterone injections as I had been using a progesterone cream. I am using 100mg a day. My progesterone began to rise nicely along with my HCg. My HCG at 8 weeks is 53,00 but last week my progesterone started to fall from its highest at 180 to 159 and then 149. My dr says he is not worried but I am exremely worried as I don't want to lose this baby too.

I am wondering whether I should use more progesterone at this stage or hang on and see if the levels drop any further?

Does anybody have any advice?

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Mar 23, 2011
Should I use more progesterone?
by: Wray

Hi Louise Transdermal progesterone works as well as injections or suppositories at preventing a drop in progesterone levels. I can only assume the amount you were using, or were recommended, was too low. It often is. You say you are using 100mg/day progesterone, I take this to mean via the injections. This is the minimum amount I recommend for normal use. If severe I suggest 200mg/day and over, going as high as 600mg/day. I can understand your concern, and suggest you monitor levels closely, having a progesterone cream handy in case you feel the need for more. We do have a page on Pregnancy, please look through it. There are plenty of studies on the page too. Take care Wray

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