Progesterone triggering herpes attacks

by Lynda

Hello,

Thanks for this amazing site. I read on one of the front pages that you said that progesterone boosts the immne system . I was told by another progesterone researcher that progesterone reduces cortisol levels. This was in response to my query about why when I use natural progesterone ( a very pure one with no other ingredients other thsn organic olive or coconut oil) it frequently triggers a herpes brekouton my buttocks within a couple of days. When i go for a period without it, I get no breakouts (unless I am very highly stressed). I took this to mean that progesteronereduced immune response and thusallows the herpes virus to activate more easily. I have searched for research on this over the years, but found none. And yet, I know of other women who have this experience. I would value any knowledge or insight you have on this issue. Your dedication to your site is truly impressive. Thanks, Lynda

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Jul 04, 2013
Progesterone triggering herpes attacks
by: Wray

Hi Lynda Bless you for the kind words about the site. If you're using the coconut oil, you're only getting about 20 to 60mg/day, am I correct? I only know one brand that makes it. This to my mind is far too low, and will only stimulate oestrogen. This would account for the outbreaks, progesterone needs to be used in far larger amounts, from 100-200mg/day if mild symptoms are experienced. Much higher if symptoms are severe. Dr Stein points out "MPA is used instead of progesterone in mouse models of sexually transmitted diseases to increase infectibility because progesterone does not have this effect. According to one recent paper, MPA increases susceptibility to genital herpes (HSV-2) ten times more than does natural progesterone.", see here. This is the paper he's referring to. Dr Stein has studied progesterone for over 40 years in his endeavour to find a safe substance for Traumatic Brain Injury, which it is. Herpes lives all over our body, as you probably know, and preferentially in the vagina, it will only cause problems when the immune system is weak, Stress weakens it. In part because progesterone levels drop, so too does vitamin D, which is very protective for the skin too. Progesterone is protective against a number of organisms, for instance Trichophyton and Microsporum fungi, see here. It's also preventative against Candida too, whereas oestrogen stimulates it's growth, as this papers says "C. albicans infection is an oestrogen dependent disorder.", see here and here. There's evidence of low progesterone levels too, see here and here. Anther study found "Treatment of epithelial and stromal co-cultures with estradiol increased HSV-2 infection in endometrial ECs, but viral shedding decreased following treatment with progesterone", see here. Continued below

Jul 04, 2013
Progesterone triggering herpes attacks Part 2
by: Wray

Hi Lynda HSV-2 is short for herpes simplex virus, type 2. And ECs is short for genital epithelial cells. This is another study here. One thing I can say that since using progesterone I have never had an outbreak of any of the above. I've had shingles once, which is another herpes disorder, candida once, and cystitis twice. Progesterone also helps this last disorder. Incidentally progesterone in oil, or a gel, is not as effective as an emulsion or cream, see here. So not only are you not getting the full benefit of the progesterone, but the low level you are using will stimulate oestrogen, an excitatory, inflammatory hormone. If you feel you need progesterone, please consider switching to a cream, and using a high amount too. There's more info on our page How to use progesterone cream. You mention that you were "told by another progesterone researcher that progesterone reduces cortisol levels". This is correct, high cortisol occurs when we're stressed, progesterone is very calming so lessens the stress response. In part by reducing cortisol as it binds to the same receptor sites, in part by activating the GABA receptors. GABA is a very calming neurotransmitter. High cortisol suppresses the immune system, so it's not surprising when we are stressed we often come down with an infection. I found this article in searching for 'high cortisol and immune suppression', fascinating as it mentions outbreaks of herpes occurring, plus cortisol suppressing the immune system, "Some of the physiological changes that occur during stress, primarily cortisol secretion by the adrenal glands, have been shown to suppress a broad spectrum of both humoral and cellular immunological responses.", see here. Take care Wray

Mar 20, 2015
I agree
by: Anonymous

Yes, I encountered the same problem. There is something that I learned that can help. 30 years ago when I got herpes, my doctor told me to take the amino acid called l-lysine 2,000 mg in the morning with breakfast and 2,000 at night with dinner. I have done this and there have been very few out breaks until I had to take progesterone.

Now on the days I take a low dose of progesterone, I keep l-lysine with me. If I feel something trying to bother me, I take an extra 500 mg. That seems to stop it. 

Best to you!

Mar 20, 2015
Just found the replies :)
by: Lynda

Thank you both. I never found your reply before, so apologies for not thanking you earlier! I got a note this time saying someone had posted.

All very useful information. Interested that you too, Anonymous, feel that progesterone stimulates the herpes virus. Perhaps we're both using too little. I have now switched to Nat Pro, so will experiment with increasing it.

Jun 28, 2015
Herpes and Progesterone
by: Mandy

Thanks so much for the above comments. I have just started HRT and have had an Oestrogen and Testosterone bio-identical implant. I am taking Progesterone orally as apparently, unlike oestrogen and testosterone, progesterone has little impact on the liver if taken orally. I found that my body did not absorb the cream. I have just had a really bad breakout of herpes on my face and on my leg - I was on 50mg a day, started bleeding after 10 days, the doctor advised to stop the progesterone until the bleeding had stopped and then restart taking one 50mg tablet every second day. Then I had this massive herpes breakout. I was unfortunately travelling at the time and email contact was sporadic at best and have only just arrived home. He advised that he will order me 35mg tablets. In the mean time, the herpes on my face is extremely painful - have been putting Tea tree oil on it but it has not been helping to relieve the itchiness and pain. Any suggestions?

Jun 29, 2015
Ouch!
by: Anonymous

Hi Mandy,

sorry you're suffering. I don't think anyone has really focussed on the progesterone triggering herpes thing. I'm sure Wray may comment on the 'can't absorb the cream' and 'little effect on the liver,' but as afar as I know only about 10% of the oral forms of progesterone is actually bio-available, as most of it is metabolised/eliminated by the liver (called the 'first pass' effect). So, by my calculation (I may be wrong), you're actually only getting about 5 or 3.5 mg of progesterone. I think the absorption rate of transdermal/intravaginal creams/gels is around 50%.

As for the herpes, I now put lysine powder in my smoothie each day and also a neat trick to help the facial herpes (as soon as you notice the tingle) is to apply hydrogen peroxide and niaouli (a form of tee tree oil), several times a day on the first couple of days, plus up your Vit C, B6 and B5. and take oregano capsules if you can find them.

As prevention (apart from the lysine), a strange thing, that many people swear by, is Liquorice Balm (www.skinshop.co.uk) applied daily - to anywhere where you tend to get outbreaks. that plus lysine keeps me outbreak free . .

Jul 01, 2015
Ouch!
by: Wray

Hi Ouch! You are quite right about the efficacy of the oral progesterone, it's the least effective Delivery system. "The liver and gut region removed a mean of 96 per cent of the progesterone entering these tissues", see here. And here, "What is common to all forms of oral replacement therapies, regardless of the hormone, is that about 10× physiological dosing is required to achieve a physiological level of the active hormone in whatever body fluid is used for testing. Most of the parent hormone administered (e.g., progesterone) is converted to inactive metabolites in the gut." So the normal physiological level is 20-40ng/ml, which would require 200-400mg/day progesterone. This is a short explanatory passage on the first pass effect. As the HRT was started at the same time as the progesterone, and knowing how adversely both those hormones affect us, it's more than likely they are the culprits. I gave much info to this woman here Thanks for the other tips you gave, I do know about lysine, but not the others, it's good to know! Take care Wray



Jul 01, 2015
Thanks!!
by: Anonymous

Yes, I read that the vaginal cream was the most effective but my doctor seemed to think that the Progesterone tablets and cream were much of a muchness. Thanks for the advice re treating it symptomatically - I have a green smoothie in the morning so will add the powder to that. The doctor prescribed Adco-Acyclovir cream which has been very effective, but it is prescription cream so it will be nice to have other remedies to nip it in the bud. It's really quite confusing as I had bioidentical oestrogen and testosterone implants last year and felt absolutely brilliant on them. I then had a massive bleed and was prescribed 200mg of Progesterone a day which caused me to have (I didn't know what it was then) an ugly herpes breakout on my chin. As my hormone levels flattened out again, I had implants a month ago and took 50mg progesterone a day. I started bleeding 2 weeks later and was advised to stop the progesterone and start with 1x50mg tablet every second day when my period stopped. This I did, but then had this really bad herpes breakout - face, arm, chest and leg!!
Thanks for advice, will definitely try it out! Good luck to you too!

Nov 20, 2016
CURE
by: Anonymous

I can’t believe this. A great testimony that i must share to all HERPES patient in the world i never believed that their could be any complete cure for HERPES or any cure for HERPES. I saw people’s testimony on blog sites of how DR Aba prepare herbal cure and brought them back to life again. I had to try it too and you can,t believe that in just few weeks i started using it all my pains stop gradually and i had to leave without the HERPES DRUGS the doctor gave to me. Right now i can tell you that few months now i have not had any pain. Delay in treatment leads to death.

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