I have been taking 300mg of progesterone cream (progesterall) daily for a year now. Most of my symptoms have greatly improved, though I still experience estrogen dominance from time to time. In any case, I am writing because yesterday I got a call from the Progesterall people asking me if I was re-selling their product since I order so much of it. They couldn't believe I was using that quantity just for myself. (And this is the John Lee company!) I was hoping they'd offer me a discount for buying so much, but they didn't.
Anyway, the guy said that because I'm using such a large quantity, it's possible for the receptor sites to become resistant to the progesterone and that I would need more and more just to maintain. He advised I start to scale back immediately so this doesn't happen. Is this something I need to worry about??? After everything I've been through with this hormone nightmare, I don't want to think my progesterone receptors are becoming resistant. I know you've said you've been using it daily for 15 years and it's still working for you. I'm just looking for reassurance.