Progesterone and thyroid

by Donna
(Katy, TX)

I was diagnosed with hypothyroidism (specifically, Hashimoto's) with a TPO of 1262. In range was 0-35. I was put on synthroid and my TPO (thyroid peroxidase antibody) immediately went down to 70. Shortly thereafter, I was put on armour and then progesterone cream (I was premenopausal and have since had a hysterectomy). My TPO shot back up to greater than 1200 and will not go down. I have been put back on synthroid but it still remains at greater than 1200.

Can you shed any light as to why this number is so high? It has been like this, now for over 2 years. I am presently on 88mcg of synthroid and 25 mcg of compounded T3. I also use 40ml of progesterone cream daily. can you also tell me what the TPO is and what can I do to get it back to, or close to, in range? PLEASE HELP! I have problems sleeping and very low libido. Thank you!!

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Progesterone and thyroid

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Hashimoto's thyroiditis
by: Wray

Hi Donna Where do I start?! TPO is not an antibody, it's an enzyme found in the thyroid gland and is vital for the production of the two thyroid hormones thyroxine (T4) and triiodothyronine (T3). It catalyses the reaction between iodine and tyrosine, an amino acid. It is stimulated by TSH (thyroid stimulating hormone), so that is probably high too.

Have your tyrosine and iodine levels been checked? If they are low, the thyroid gland will not be able to make the two hormones T3 and T4. Antibodies against TPO are found in diseases such as Hashimoto's. Please get them to check your glutathione levels, if this is low the immune system struggles.

I would suggest you take the precursor's to glutathione, the amino acids N-acetyl cysteine, glutamine and glycine, all readily available in health shops. Take at least 2000mg/day of each. Plus the mineral selenium, preferably an amino acid chelate, 200mcg/day. Glutathione needs selenium and there is also evidence that selenium reduces levels of thyroid peroxidase antibodies.

The progesterone is a good choice, but you say 40ml... I would need to know the strength to help further. All the successful studies done on progesterone use between 100mg to 200mg per day. This equates to 3ml to 6ml of Natpro per day. Some go as high as 400-600mg/day, one going as high as 1200mg/day as it was the oral variety. Hope this helps! Take care Wray

Selenium Supplementation in Patients with Autoimmune Thyroiditis Decreases Thyroid Peroxidase Antibodies Concentrations
http://jcem.endojournals.org/cgi/content/abstract/87/4/1687?
maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=sel
enium-
dependent+glutathione+peroxidase+in+thyroid+cells&searchid
=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT

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Submitted by: Wray

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Hi Donna Where do I start?! TPO is not an antibody, it's an enzyme found in the thyroid gland and is vital for the production of the two thyroid hormones thyroxine (T4) and triiodothyronine (T3). It catalyses the reaction between iodine and tyrosine, an amino acid. It is stimulated by TSH (thyroid stimulating hormone), so that is probably high too. Have your tyrosine and iodine levels been checked? If they are low, the thyroid gland will not be able to make the two hormones T3 and T4. Antibodies against TPO are found in diseases such as Hashimoto's. Please get them to check your glutathione levels, if this is low the immune system struggles. I would suggest you take the precursor's to glutathione, the amino acids N-acetyl cysteine, glutamine and glycine, all readily available in health shops. Take at least 2000mg/day of each. Plus the mineral selenium, preferably an amino acid chelate, 200mcg/day. Glutathione needs selenium and there is also evidence that selenium reduces levels of thyroid peroxidase antibodies. The progesterone is a good choice, but you say 40ml... I would need to know the strength to help further. All the successful studies done on progesterone use between 100mg to 200mg per day. This equates to 3ml to 6ml of Natpro per day. Some go as high as 400-600mg/day, one going as high as 1200mg/day as it was the oral variety. Hope this helps! Take care Wray Selenium Supplementation in Patients with Autoimmune Thyroiditis Decreases Thyroid Peroxidase Antibodies Concentrations http://jcem.endojournals.org/cgi/content/abstract/87/4/1687? maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=sel enium- dependent+glutathione+peroxidase+in+thyroid+cells&searchid =1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT

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