Progesterone and multiple sclerosis

by Janet
(UK)

I have been on Chemotherapy (Mitoxantrone) as a treatment for multiple sclerosis every 3 months for the past 9 months. I was wondering if anyone has any experience of or comments to make about MS, Chemo and Progesterone treatment.

The chemo is not working that well as I believe it is supposed to pretty much halt the progression of MS and I have only experienced a week or 10 days a month when I feel well. My menstrual cycle nearly stopped initially but I believe I ovulate and my symptoms worsen in the weeks following. I have had very light or very heavy bleeds.

Any comments welcome.

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Progesterone and multiple sclerosis

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Chemo and MS
by: Trish

No, chemo really isn't the usual treatment for MS. It is one option for those who are moving onto secondary progressive.

I did that treatment, among many others, and found that it just increased the likelihood that I would get a UTI, which triggers an episode, etc, etc. I stopped it. I've ended up on Tysabri, plus paying attention to my food allergies and I'm doing much better.

Good luck, Trish

Progesterone and multiple sclerosis
by: Wray

Chemo is the usual treatment for MS, but there is much evidence progesterone regenerates nerves. Emory University have been studying it for 20 years now and have found it remarkable for brain trauma victims, who were given it via IV transfusion. Incidentally 71% of the patients were men.

It reduces programmed cell death and the synthesis of inflammatory factors that can kill neurons hours to days after traumatic brain injury, promotes regeneration and myelination of axons, has a neuroprotective and antioxidant effect in injured nervous system, has multiple effects on glial cells, it influences growth, differentiation and increases the expression of myelin-specific proteins in oligodendrocytes, and potentiates the formation of new myelin sheaths by Schwann cells in vivo and finally it enhances remyelination in degenerative disorders.

Because of the success with TBI and the fact progesterone helps nerves regenerate, they are going to do a study on MS patients, also stroke patients, as they believe it could help. We know a number of people who have used progesterone successfully, but like all natural things, it's not a quick fix. Hope this helps.

"Local synthesis of PROG in the brain and the neuroprotective and promyelinating effects of this neurosteroid offer interesting therapeutic possibilities for the prevention and treatment of neurodegenerative diseases, for accelerating regenerative processes and for preserving cognitive functions during aging."
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG5-4CBD3JV-
7&_user=5417390&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C00
0050221&_version=1&_urlVersion=0&_userid=5417390&md5=1636cd0135b92
77fb5d76798a1a7e74d

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Submitted by: Wray

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Chemo is the usual treatment for MS, but there is much evidence progesterone regenerates nerves. Emory University have been studying it for 20 years now and have found it remarkable for brain trauma victims, who were given it via IV transfusion. Incidentally 71% of the patients were men. It reduces programmed cell death and the synthesis of inflammatory factors that can kill neurons hours to days after traumatic brain injury, promotes regeneration and myelination of axons, has a neuroprotective and antioxidant effect in injured nervous system, has multiple effects on glial cells, it influences growth, differentiation and increases the expression of myelin-specific proteins in oligodendrocytes, and potentiates the formation of new myelin sheaths by Schwann cells in vivo and finally it enhances remyelination in degenerative disorders. Because of the success with TBI and the fact progesterone helps nerves regenerate, they are going to do a study on MS patients, also stroke patients, as they believe it could help. We know a number of people who have used progesterone successfully, but like all natural things, it's not a quick fix. Hope this helps. "Local synthesis of PROG in the brain and the neuroprotective and promyelinating effects of this neurosteroid offer interesting therapeutic possibilities for the prevention and treatment of neurodegenerative diseases, for accelerating regenerative processes and for preserving cognitive functions during aging." http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG5-4CBD3JV- 7&_user=5417390&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C00 0050221&_version=1&_urlVersion=0&_userid=5417390&md5=1636cd0135b92 77fb5d76798a1a7e74d

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