Progesterone and breast cancer

by Solary
(San Juan, Puerto Rico)

I'm 62, have a history of miscarriages, heavy periods, hair in face, not very maternal, fibroids, hysterectomy and now breast cancer.

I want to know if I can use progesterone if I already have breast cancer.

Also my daughter had some blood tests done because of rage fits. She has very high testosterone, high dopamine and norepinephrine. They did not test her estrogens or progesterone. My concern is if she uses the progesterone to balance testosterone and presumably estrogens, will the dopamine rise even more?

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Progesterone and breast cancer

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Apr 21, 2010
 Lack of progesterone and excess oestrogen
by: Wray

Hi Solary. What a tough road. Your symptoms point to a lack of progesterone and excess oestrogen. Miscarriages are often caused by a lack of progesterone. It can stop heavy bleeding, caused by excess oestrogen. It prevents facial hair by suppressing oestrogen. Excess oestrogen is converted into androgens, these cause facial hair on both men and women. Oestrogen is a mitogen so stimulates both fibroids and cancer cells. Please see this on progesterone and cancer. And this on cancer. Dopamine is produced in response to rewarding stimuli like food and sex. But it appears that aggression may stimulate the release of dopamine, serving as positive reinforcement for aggression. Another known factor is that low serotonin levels predispose people to impulsive aggression, with high dopamine levels being an additional burden. Increased noradrenaline levels have been found in aggressive individuals. An increase of these two hormones prevents progesterone from entering cells. Testosterone is associated with aggressive behaviour, and high levels are found in aggressive people. Cortisol influences testosterone levels. All this suggests that the high testosterone in your daughter is stimulating dopamine leading to the outbursts. Please see these... Paper 1, Paper 2, Paper 3. It appears your daughter is stressed, as this impacts on hormones and neurotransmitters. It appears her ovaries are not functioning normally, have they been checked? Ovaries produce both oestrogen and testosterone during the follicular phase, evidently they are producing too much testosterone. It could be she's not ovulating, progesterone is only made when this occurs. With sufficient ovarian progesterone excess oestrogen and testosterone are suppressed, this doesn't appear to be happening. I do believe progesterone will help your daughter, as it suppresses high testosterone and high cortisol. She will probably need around 200mg/day initially. Progesterone is very calming, as it activates the GABA receptor sites, GABA is one of our most calming neurotransmitters. It will also relieve the strain on your daughters adrenals, which are working overtime making the adrenaline/noradrenaline, plus the other stress hormone cortisol. The adrenals make progesterone, which is then converted into cortisol, supplementing will certainly assist them. I suggest she takes tryptophan the precursor to serotonin, plus the amino acid taurine, this is very calming. For more information on these please see here. Take care, Wray

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