How Does Progesterone Finally Overcome Estrogen Dominance?

by Brenda

First I'd like to thank you for stepping outside the box to help yourself and others to find a better quality of life. I'm an RN and a natural health consultant. I get excited when I see others finding ways and methods of healing that have been overlooked or dismissed by the mainstream.

Natural progesterone therapy is a fairly new realm for me. I'm almost 49 years old and about 5 years ago started becoming aware of the very prevalent estrogen dominance issue on this planet. However, I did not really start looking into progesterone therapy until recently as my specialty is detoxification and digestive healing. As I step further into the world of hormones I see more and more how toxicity and digestive issues intricately wrapped around hormone issues.

I feel I have been estrogen dominant since the age of 15. Stressful childhood, drinking alcohol starting at around the age of 14 followed by more chaos as the years progressed. I finally cleaned up my act about 20 years ago and went on to open my own detoxification and digestive healing business.

I started using progesterone cream about 8 weeks ago using about 200mg per day. After a couple of days of continual headaches and nausea, things improved. Moods much better, deeper sleep, better skin. Up until I started using the cream I had a 28 day cycle. I chose to use the cream continuously as I didn't use the cream on the first day of the first period and got extremely agitated. By that night I was desparate and used it with much relief. I've since had one more period (24 days later) and used straight through and had a lighter shorter period with less PMS symptoms prior to its onset.

I retain a lot of water all month long, for years now, since my twenties but much more so in my forties, and other lab work has shown no serious conditions causing the water retention. I had two children in my late 30's and retained huge amounts of water, especially with the first pregancy. I've been diagnosed with adrenal exhaustion on and off per saliva testing by a naturally inclined MD, and I take about 2.5mg Cortef twice daily for 3-6 months at a time for about 10 years on and off during stressful times. I've currently been back on the Cortef since November. The progesterone really helps me to sustain a more even energy pattern. I haven't gained any weight while using the progesterone cream but haven't lost any water weight. I've been quite puffy for about 2 years now and will have wild weight swings from day to day of 1-3 pounds. Breasts will gain 2 inches from morning to noon. Crazy. I know it takes time, 3-6 months. 8 weeks later with no water weight loss is discouraging but I'll continue to hope. I take other supplements to support my system, blood sugar balancers neurotransmitter support, etc. Many are the same as what you recommend. I agree with your recommendations.

Two questions:

1) What is your stance on continuous use of progesterone cream at around 200mg per day possibly causing progesterone receptor sites to become desensitized?

2) I have some difficulty understanding how the dormant estrogen receptors sites that are activated by progesterone don't cause a perpetual state of estrogen dominance. At what point does the progesterone finally get a chance to become dominant? If the progesterone is continually activating the dormant sites, does at some point the level of progesterone get high enough that this stimulation of estrogen receptors no longer causes issue, or do the estrogen receptor sites finally ALL get turned on completing that process thus allowing progesterone to get a stronghold? In other words, how is the balance finally achieved where progesterone wins? ;)

Any insight into these matters would be most appreciated. Thanks again Wray. Much love and peace.

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Mar 05, 2011
How Does Progesterone Finally Overcome Estrogen Dominance?
by: Wray

Hi Brenda Firstly apologies for the late reply, I'm inundated with queries from our web site. I'd be only too delighted if you would chip in and help! Assuming the progesterone finally helps you. And bless you for the kind words, luckily my brother and I had an eccentric father, grandfather too, who thought out of the box. Besides I'm not affiliated to any governing body, who I'm sure would have struck me off their register by now! You are so right about the intricacy between hormone issues and detoxification. For instance excess oestrogen causes cholestasis, with a blocked liver no one can detox! See here, here, here, here, here, here and here. I have more work to do on progesterone, but this paper shows it increases bilary output of choelsterol, see here. I'm delighted you used a high amount to begin with, I find it hard to persuade people it's the only thing which will help, a low dose merely ramps up the oestrogen. You are now in Peri-menopause, which can be difficult, it was for me. I chose to use it daily too, as my symptoms came back if I took the customary break after bleeding. I continued to do so, which meant I didn't forget to start it at ovulation, plus it made the menopause transition smooth. Interesting about the adrenal exhaustion, it doesn't surprise me, if as you say you've been oestrogen dominant since 15. This implies a lack of progesterone. I've found this above all else the best for stressed adrenals. These first make progesterone in the cortex, they then convert it into cortisol. If stressed this sequence is compromised, so the adrenals rob ovarian progesterone. This is turn plays havoc with our reproductive functions. Plus progesterone blocks the aldosterone receptors. As you know aldosterone causes sodium retention, which in turn causes water retention. If you lack progesterone, I would hazard a guess it's correcting the adrenal dysfunction first. It's impossible to tell which system the body regards as the most in need. I'm running out of space, so will start a new comment. It'll appear below this one. Take care Wray

Mar 05, 2011
How Does Progesterone Finally Overcome Estrogen Dominance?
by: Wray

Hi again Brenda Progesterone is an excellent diuretic, so good it's now given via IV transfusion to brain trauma victims. It prevents the oedema and inflammation that does the damage, see here, here, here and here. I haven't seen a problem yet caused by desensitised progesterone receptors, and that's with over 15 years of advising. Unfortunately the web is full of forums warning about saturating the fatty layer! This is an essential part of the progesterone pathway, see here. I think a high amount is only necessary as long as the problem persists. Once it's been resolved, I see no point in continuing, apart from the cost! I've had women using 400-600mg/day for several months, as each time they try to reduce, their symptoms come back. Usually within the 3 to 6 months they can begin reducing slowly. It also depends on the problem, for instance I've found 500mg/day is needed if endometriosis is severe. This will take several weeks, if not months to heal. Severe, heavy, continual bleeding requires 400-600mg/day, once under control it's pointless staying at that amount. The interplay between hormones, neurotransmitters, and other messenger systems is so complex, I wish I knew more! Progesterone does activate the oestrogen receptors, but the converse also occurs. So ironically when first using progesterone and a low amount, people generally feel awful. But when using oestrogen they feel good! But there comes a point when progesterone does become dominant and they start to feel well. And as with oestrogen, they begin to feel worse. So the script is changed repeatedly, until the woman stops using it, or as in many women I know, they become inured to the effects. When progesterone becomes dominant is difficult to say, but I have found the more oestrogen a woman, or man has, the longer it takes, and the worse the Oestrogen Dominance. I have found that a lack of vitamin D has a profound effect on us, as it influences every cell. The TBI studies found it increased the benefits of progesterone. See the Vitamin D council website. love and peace to you too! Take care Wray

Jan 12, 2014
Application of Natpro.
by: Bill

I am confused as to the amount to use. How do you determine/measure what is a 100mg amount for example of cream, when you dispense from the tube?

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