by Linda

I had a total hysterectomy at age 35. I was put on an estrogen patch. Suffered with depression & was on antidepressants. Found a dr that prescribed bio identicals.

I use Biest 1.5 estrogen/3.0 progesterone. Also have estroil vaginally 2 or 3 times a week, & testosterone cream on vulva 2 or 3 times a week. A year ago I got off of the antidepressants, but I have terrible mood swings, depression. I tried Estrablend & for 3 months I was on top of the world. Then back to depression. I talked to the compounding pharmacy & they told me I shouldn't have taken that & once I was off it for 3 weeks they would up the Biest progesterone.

I cry & feel like I am going nuts. Should I have more progesterone & less estrogen? Also, at times my nipples get really sore. Any advice would be helpful as I don't want to go back on antidepressants & I am driving my husband with my up & down moods. Am not interested in anything, irritable, angry, cry, etc. Thanks.

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Sep 10, 2010
by: Wray

Hi Linda A total hysterectomy removes the ovaries too. Something doctors forget, these also make progesterone, but it's never given to a woman, only oestrogen. It doesn't surprise me you suffered depression. I don't believe any woman needs extra oestrogen, whether natural or synthetic. And certainly not testosterone, often given to raise libido, but there's evidence it's progesterone which is responsible for this. Excess oestrogen and testosterone suppress progesterone, I think this is all you need. But the amount should be between 100-200mg/day, anything less and it takes far too long for progesterone to become the dominant hormone. Judging by your symptoms you would do best on the higher amount initially. For more info please see our page on How to use progesterone cream. If you do consider using progesterone only and a higher amount, please read this page on Oestrogen Dominance first. The hyst has put you into menopause, so you might like to read our page on Menopause. I suggest rubbing the progesterone on your breasts if the nipples get sore, it's excellent for sore breasts too, please see here, here and here. Finally you might like to read our page on Anxiety. Take care Wray

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