Dermal fatigue

by Heather
(London UK)

Sorry but I have looked all over your website for info on this subject and found nothing. This week Dr Mercola posted an article on the wonders of natural progesterone but the problems of dermal fatigue with long term use. He states it stays put in the fatty tissues and disrupts the levels of DHEA and cortisol etc.

He never, however, gave a clear solution to this problem other than to use it vaginally.

I am presently taking 2.5 ml twice a day continuously ( I went through menopause 5 yrs ago and have tried all different balances of biodentical hormone therapy). This seems to be working the best for me as I was able to stop taking Biest when I increased my Natpro dosage. I feel much happier and my bloating has completely disappeared.

I am now worried though about dermal fatigue and associated problems with disrupting other hormones. Please can Wray clarify the best methods of using the cream to avoid this happening?

Thank you kindly.

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Dermal fatigue

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Sep 21, 2011
 Dermal fatigue
by: Wray

Hi Heather I'm delighted the progesterone has helped you, you use about the same amount as I do. I don't have a page on dermal fatigue, maybe I need to do one! I have answered this query quite frequently recently, as like you, others have seen Dr Mercola's comment. I can't agree with it, from personal experience I've found my receptor sites are working fine. I occasionally experiment and use 10ml per day, I get bad Oestrogen Dominance. The main symptoms being aching in every joint, tired, irritable and feeling so old! I do this for about 2 weeks to top myself up, by which time the symptoms have gone. Then I slowly reduce back down to the amount I normally use. I also use some in my vagina every night, and have done so for the past ±5 years. It's an excellent place to apply the cream, helping prevent dryness, inflammation and it's protective against Candida too. I don't know how progesterone can disrupt cortisol, other than to inhibit it. Too much cortisol is not a good thing either, so as far as I'm concerned this inhibition is an advantage. When stressed the adrenals produce cortisol, adrenaline and noradrenaline. But to produce cortisol, the adrenals first have to produce progesterone, this they then convert to cortisol. If very stressed the adrenals can't cope with the amount of progesterone needed for the conversion, so they rob other sources, notably from the ovaries. This is the reason stress drops progesterone levels, and the reason stress upsets the reproductive system. In fact stress can stop ovulation, but without ovulation, no ovarian progesterone is made. So a vicious cycle starts. Progesterone is also very calming, as it activates the GABA receptor sites, GABA is one of our most calming neurotransmitters. By so doing, progesterone lessens the stress response, which of course helps the adrenals! One way of finding out if you have dermal fatigue, is by doing what I do and use substantially more. A friend recently tried this and had a hot flush after years of being free, she was not amused! But it satisfied her curiosity that her receptors were working fine. Take care Wray

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