Natpro is really helping but need a little advice

by Jackie
(England)

Hi Wray, I recently bought Natpro after trying another make and it is really helping. I don't have a break from it as I have had a hysterectomy so no cycle to guide me, however, I do have one ovary so experience pmt symptoms.

I just wanted to ask your advice about this as at certain times of the month I still do not feel right, my hair goes greasy, I'm tired, sluggish and feel tearful with a feeling of worthlessness and low mood. Also my breasts increase in size and I have noticed I get cold sweats along with more perspiration which for some reason smells different, what's going on? The rest of the time the cream helps me feel great with more energy, a brighter mood and a positive outlook!! I use about a teaspoon a day split morning and night and have been using it since last August.

Please can you advise me on this as I really do think the cream helps the rest of the time and would recommend it. Thank you. With kind regards, Jackie.

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Natpro is really helping but need a little advice

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Mar 18, 2011
 Natpro is really helping but need a little advice
by: Wray

Hi Jackie I'm so happy the cream is helping you. A hyst does throw us into turmoil, even keeping the one ovary. The amount you are using pleases me, so often too little is used, and this merely increases the adverse symptoms. It seems your one ovary is still working, still producing oestrogen, which is upsetting things. I suggest you increase the amount you're using during those 'off' days. If you can tell when they are coming, start applying the higher amount, don't wait till they occur. Rub some of the cream on your breasts too, this does help. Interesting about the greasy hair and the change in perspiration smell. This is probably caused by excess androgens. All women make more testosterone than oestrogen each month, but most of it is converted by the enzyme aromatase. If something disturbs this sequence, excess testosterone occurs. Testosterone is responsible for greasy hair, skin, spots and acne. The arm pit has two sweat glands, eccrine which produce what we know as sweat. And apocrine which produce a thick secretion containing cholesterol, hormones, fats and protein. This is apparently only produced in response to emotional stress. But from correspondence I've had, I believe it could also arise from our hormones being out of balance. Although it has no smell, bacteria living on the skin break it down with enzymes releasing an odour. The offending substances are fatty acids and the androgen steroids, especially 5-alpha androstenol and 5-alpha androstenone. These androgens are pheromones found in human sweat glands and urine, see here and here. The enzymes the bacteria secrete are beta-glucuronidase and aryl sulfatase. Steroid malodour production can be prevented by inhibitors of beta-glucuronidase and aryl sulfatase. Oestrogen and the androgens are metabolised in the liver by glucuronic acid, the process is known as glucuronidation. The process also removes other substances, including toxins, drugs, bilirubin, mineralocorticoids and glucocorticoids. It's then excreted in the bile, but an enzyme in the intestine called beta-glucuronidase breaks the steroid/glucuronide bond, which allows the steroids to be reabsorbed. Calcium D-glucarate inhibits beta-glucuronidase. I don?t know what inhibits aryl sulfatase. So I suggest you get some calcium D-glucarate and try taking it, see if that helps. Incidentally this enzyme is produced by undesirable gut bacteria too, supplementing with probiotics suppresses the bacteria, and subsequently the beta-glucuronidase. Take care Wray

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