Wray - About Glycine and Taurine: Do they compete for the same receptors?

by Beansprout

Hi Wray,

I read somewhere that Taurine and Glycine compete for the same receptors in the brain and should not be taken or combined together, is this true? If so, what is your recommendation as far as dosages. Do I space them by a few hours. I currently take 4,000 mg of Taurine and 600 mg Theanine divided throughout the day. But i want to also add Glycine at night to see how it effects my quality of sleep and its effect on my hypoglycemia symptoms. I would appreciate you shining your light on this subject.

Thanks!

Beansprout

Comments for Wray - About Glycine and Taurine: Do they compete for the same receptors?

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Jul 11, 2013
Wray - About Glycine and Taurine: Do they compete for the same receptors?
by: Wray

Hi Beansprout Yes it does appear they do, but I haven't found it something to really worry about. Besides all hormones and neurotransmitters work on an agonist/antoagonist basis with each other, " β-Alanine and taurine are structurally similar to glycine (Fig. 1A), and all agonists compete for the same binding site (Schmieden et al., 1992; Schmieden and Betz, 1995) According to a single-channel kinetic analysis, dissociation rates for β-alanine and taurine are increased 2.5- and 4-fold, respectively (compared with glycine), and efficacy by 2- and 5-fold, respectively", see here. Life is complicated enough without wondering if something we take is going to have an agonistic affect or an antagonistic affect, we'd go barmy! In fact we make up a calming complex with all the calming aminos and have only had success with it. In fact in this study here it appears to be a beneficial thing, "We conclude that supraoptic neurones express high amounts of glycine receptors, of which taurine may be regarded as a major natural agonist.We postulate that taurine, which can be released in hyposmotic situations, acts on glycine receptors to exert an inhibitory control on magnocellular neurones during alterations of body fluid homeostasis, implicating an active participation of glial cells in this neuroendocrine regulatory loop." Hope this helps! Take care Wray

Jul 12, 2013
Wray - Just to Clarify
by: Anonymous

Wray - That's a lot to process for my less than scientific brain. But I appreciate the information nonetheless. For clarification purposes, in more layman's terms, it is perfectly safe to combine the two without making one less effective than the other? Strangely, the other night, I took my usual 1000 mg of Taurine, 200 mg of Theanine, my CALM drink and 1/2 tablet of Glycine and instead of going right to sleep and staying asleep as I have for the last week or so I had difficulty finding any sleep at all. Not that I was stressed or anxious. I just wasn't tired and stayed awake most of the night staring at the ceiling. Since then I continue to take Glycine throughout the day at separate times that I take the Taurine and Theanine and avoid taking it before bedtime and quality sleep has returned. I would love to learn more about your combination formula you mentioned.

Beansprout

Jul 12, 2013
Wray - Just to Clarify
by: Wray

Hi Beansprout You did give me a chuckle! I don't intend to bamboozle people with studies, but it is important to me to give them out, that I'm not fabricating something. It's very lucky I'm not trying to explain genetics to someone, as that is baffling to me. In fact I defy anyone to read a paper out loud, it would sound like a mouth full of marbles! Take this paper for instance, try reading it to a family member, I would love to see their response! I've seen worse too. So to answer your question, it is safe to combine them, they come combined in the food we eat. But yes they do compete in some instances, so staring at the ceiling is not an option! Continue as you are. The complex we make we suggest taking in the morning, it wasn't intended to help sleep, but to calm down. It contains all the calming aminos, GABA, glutamine, glycine, taurine and tyrosine, the co-factor vitamins, some of which calm, inositol which helps sensitise the body to insulin so making blood glucose come down. If this is too high is can cause agitation. Chrome and zinc for blood glucose control, and all our complexes contain vitamin D. They all come in powder form too to make them cheaper. The amount of each nutrient is far higher than that found in a capsule, all based on the amounts used in studies. It's one of our complexes not on the site which is a pity, as it does work. I love experimenting with things, currently we're formulating a vitamin D cream which I find delicious. And we're doing an acne cream which we've had some success with so far, and we're doing a wound healing/bug killing cream! Take care Wray

Jul 15, 2013
Wray - The Complexes
by: Beansprout

Hi Wray - When you say the complexes are not on the site, does that mean they are not available for sale and, if they are, can you provide a link to provide and pricing information?

I like experimenting, too. You should see my kitchen cupboard. I one specifically for natural healing remedies. It looks like the evil professor lives here. But by researching and trying different approaches I have found so many benefits to everyday health concerns from the common cold to insect stings. So perhaps you're my soul sista! =)

Beansprout




Jul 18, 2013
Wray - The Complexes
by: Wray

Hi Beansprout It's only the Calming Complex which isn't on the site, the other two we have are. One can be found on our Insulin Resistance page and the other on our PCOS page. There's a click through to the complex itself. We also have one for inflammation but that's not on the site either. We need to get them made up in bulk to make them cost effective. Currently they are made by a small lab in small quantities. I love your evil professor! You should have seen my brother and I doing the wound healing cream, we thought we'd made a new life form! It had a mind of it's own and did not behave as it should bubbling over the container as it did. So yes soul sista! It is so important to experiment, to find out for ourselves, and not accept what we're told. Take care Wray

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