"What about Factor V and Protein Deficiency Disorders?"

by Vern Bingham
(Bluffdale, Utah USA)

My Granddaughter passed away from a massive blood clot in her brain. Tests revealed that she had both factor V and protein deficiency blood disorders. As a result my whole family has had the appropriate DNA tests and my wife has factor V disorder. The Doctor told her to stop taking premrin because estrogen can cause blood clotting. Now my wife is having all the symptoms of menopause again. She had a complete historectomy several years ago but the premrin stoped the hot flashes etc. I have investigated natural herbs etc. the medical enviroment says herbs are to dangerous but the herb people say they are safe and only help the body maintain normal hormone balance. Who do I believe? Is progesterone safe to use with factor V? I need help!

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Mar 23, 2012
"What about Factor V and Protein Deficiency Disorders?"
by: Wray

Hi Vern I'm so sorry to hear about your granddaughter. You say you wife has Factor V, a deficiency of this can lead to bleeding, but a mutation such as Factor V Leiden (FVL) leads to clots. I'm not sure which she has. Assuming she has the mutation then exogenous oestrogen increases the risk of clots, irrespective of whether a person has protein C and/or S deficiency, or hyperhomocysteinemia. Having any of these pathologies increases the risk further, oestrogen in any form is contraindicated. Please see our page on HRT. And these papers here and here. In FVL, factor V remains active, which allows over production of thrombin, leading to excess clotting. Oestrogen increases the affect of thrombin, progesterone on the other hand decreases it by 10-15%, please see here. It also protects against lipid peroxidation and atherosclerosis, please see here and here. The medical fraternity would say herbs are dangerous, but they're not. They've kept us alive for millennia, long before drugs came on the market! Please ask her to have a vitamin D test done. None of us gets enough sun now, so levels are low the world over. Vitamin D stimulates thrombomodulin, this inhibits thrombin, and activates protein C, see here. and here. Vitamin D prevents clotting in numerous ways, see here, here, here and here. Interestingly a lack of vitamin D reduces the benefits of progesterone. This was discovered during studies on Traumatic Brain Injury victims. Continued below.

Mar 23, 2012
"What about Factor V and Protein Deficiency Disorders?" Part 2
by: Wray

Hi Vern Your wife is in Menopause now, this page gives details on how to use progesterone. Before she considers using it, please ask her to read our page on Oestrogen Dominance. We also have a page on Hot Flushes. Please ask her to have a vitamin D test done. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Take care Wray

Mar 23, 2012
Thank you
by: Vern Bingham

Wray, thank you for the valuble information. Your response is so much appreciated. I will be busy reading and investigating all of the sources given.

Mar 24, 2012
Thank you
by: Wray

Hi Vern It's a pleasure! Take care Wray

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