Total Hysterectomy and on HRT

by Krista
(Lakeland FL)

I am 36 years of age. I had a total abdominal hysterectomy in 2006, and since then have been taking Premarin 1.25 mg/day.

I have noticed weight gain, cravings of more foods, and binge eating. Even though I was told that I wouldnt gain weight, I have >10lbs. I was told that it was not necessary to take progesterone because my uterus is gone.

I take my Premarin faithfully without question but still need a better explaination why progesterone is not needed. How could I benefit from progesterone supplement? What are the side effects/ what harm could it do if taken with my Premarin? Do I still need progesterone? I am well aware of the dangers of taking Premarin, but would progesteron increase these risk?

Is the progesterone necessary?

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Total Hysterectomy and on HRT

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May 31, 2008

HRT and progesterone
by: Wray

Hi Krista. Oestrogen does cause an upset in blood sugar. This is one of the reasons farmers give it to cattle... it makes them eat more. Oestrogen also increases fat cells, good for farmers not for women! Fat cells generate more oestrogen, so a vicious cycle is started.

Oestrogen is also known to cause insulin resistance. This, amongst other things, can cause binge eating, tiredness, weight gain. Progesterone helps to correct an imbalance in blood sugar and it cannot increase fat cells. Oestrogen and only oestrogen stimulates cells to grow, hence it's danger. Without progesterone there is nothing to stop it stimulating the cells in your breasts.

Another study on the increased risks has just been released in Germany, link below. So no harm or adverse side affects would occur using progesterone with Premarin, although I would prefer you did not use HRT. Everything in the body works in balance, there is always an opposing force or bio-chemical to maintain this. Muscles, hormones, minerals, neurotransmitters, they must work in pairs. To give only oestrogen and not progesterone will cause an imbalance.

Unfortunately they are over 90 oestrogen mimics on this planet now. We can't avoid them. In our food, air, water, the skin care we rub all over ourselves, and more. We all have an overload of oestrogen, hence the need for progesterone. What we need is organic food and skin care, clean air and water, then there would be no need for supplemental progesterone! Take care Wray

International Journal of Cancer 2008, DOI 10.1002/ijc.23655
Risk of Different Histological Types of Postmenopausal Breast Cancer by Type and Regimen of Menopausal Hormone Therapy.
http://www.dkfz.de/en/presse/pressemitteilungen/2008/dkfz_pm_08_32.php

Endocrine disruptors:
Our Stolen Future
http://www.ourstolenfuture.org/index.htm

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May 31, 2008
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Submitted by: Wray

Title

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Hi Krista. Oestrogen does cause an upset in blood sugar. This is one of the reasons farmers give it to cattle... it makes them eat more. Oestrogen also increases fat cells, good for farmers not for women! Fat cells generate more oestrogen, so a vicious cycle is started. Oestrogen is also known to cause insulin resistance. This, amongst other things, can cause binge eating, tiredness, weight gain. Progesterone helps to correct an imbalance in blood sugar and it cannot increase fat cells. Oestrogen and only oestrogen stimulates cells to grow, hence it's danger. Without progesterone there is nothing to stop it stimulating the cells in your breasts. Another study on the increased risks has just been released in Germany, link below. So no harm or adverse side affects would occur using progesterone with Premarin, although I would prefer you did not use HRT. Everything in the body works in balance, there is always an opposing force or bio-chemical to maintain this. Muscles, hormones, minerals, neurotransmitters, they must work in pairs. To give only oestrogen and not progesterone will cause an imbalance. Unfortunately they are over 90 oestrogen mimics on this planet now. We can't avoid them. In our food, air, water, the skin care we rub all over ourselves, and more. We all have an overload of oestrogen, hence the need for progesterone. What we need is organic food and skin care, clean air and water, then there would be no need for supplemental progesterone! Take care Wray International Journal of Cancer 2008, DOI 10.1002/ijc.23655 Risk of Different Histological Types of Postmenopausal Breast Cancer by Type and Regimen of Menopausal Hormone Therapy. http://www.dkfz.de/en/presse/pressemitteilungen/2008/dkfz_pm_08_32.php Endocrine disruptors: Our Stolen Future http://www.ourstolenfuture.org/index.htm

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Oct 30, 2008

TAH-BSO at age 36, six years ago
by: Lori

I tried and tried to keep the estrogen low, right after the less than hoped for results of the WHI study... and after a year or so started Premarin at .9 mg daily. I still felt a little creaky and stiff in the joints, so increased to 1.25 mg, which my doctor pointed out was probably much lower than what my ovaries used to do on their own.

I wanted to stick up for you and your choice. It's so easy for people with their ovaries or going through a normal menopause at a normal age to make blanket statements like "you should not take hormones". You are young and your body was intended to have the estrogen at least til 40 if not 50.

You can't consider just the breast cancer risk... my breast doctor (who performed a surgical biopsy on a lump a year before the hysterectomy) was completely in favor of ERT until normal menopause age. In her words, "you have to treat the whole person" and not just her breasts. Unless you have serious family history or the gene... you have lots of other body parts to take care of that are gonna miss the estrogen in ways you will be amazed by.

I'm 43 now, and just took the dose back down to .9 mg daily. I plan to stay on Premarin at least until I retire from my stressful job at 47. Then, we'll see. I think it's reasonable to expect to taper off in the 50's, and I hope they'll know more and someone will study women like us... who need more than a little black cohosh and red clover.

I gained about 10 pounds too, and lost some muscle to fat since the surgery. Like women who've had kids, I've had to accept I'll never get that old body back. Be gentle and accepting with the one you have now, and take good care of it and cut yourself some slack.

There's a web site... look up hyster-sisters. Not all accurate info but a lot of support if it would help to hear other stories a lot like yours.

Good luck, and hang on to your sense of humor.

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Oct 30, 2008
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Submitted by: Lori

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I tried and tried to keep the estrogen low, right after the less than hoped for results of the WHI study... and after a year or so started Premarin at .9 mg daily. I still felt a little creaky and stiff in the joints, so increased to 1.25 mg, which my doctor pointed out was probably much lower than what my ovaries used to do on their own. I wanted to stick up for you and your choice. It's so easy for people with their ovaries or going through a normal menopause at a normal age to make blanket statements like "you should not take hormones". You are young and your body was intended to have the estrogen at least til 40 if not 50. You can't consider just the breast cancer risk... my breast doctor (who performed a surgical biopsy on a lump a year before the hysterectomy) was completely in favor of ERT until normal menopause age. In her words, "you have to treat the whole person" and not just her breasts. Unless you have serious family history or the gene... you have lots of other body parts to take care of that are gonna miss the estrogen in ways you will be amazed by. I'm 43 now, and just took the dose back down to .9 mg daily. I plan to stay on Premarin at least until I retire from my stressful job at 47. Then, we'll see. I think it's reasonable to expect to taper off in the 50's, and I hope they'll know more and someone will study women like us... who need more than a little black cohosh and red clover. I gained about 10 pounds too, and lost some muscle to fat since the surgery. Like women who've had kids, I've had to accept I'll never get that old body back. Be gentle and accepting with the one you have now, and take good care of it and cut yourself some slack. There's a web site... look up hyster-sisters. Not all accurate info but a lot of support if it would help to hear other stories a lot like yours. Good luck, and hang on to your sense of humor.

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Jun 04, 2009

HELP
by: Anonymous

I had a complete Hysterectomy in 2003. I never have taken any estrogen replacement. I have no sex drive and its very difficult to have sex because of pain. Can you help me?

Jan 11, 2010

Compound progesterone
by: kim

I too have had a total Hysterectomy and on Estradiol
Transdermal 0.075 for about 5 years. My new ob doctor has lowered the dosage for Estradiol 0.05 and compound 100mg progesterone. Still not feeling all that.

Jan 19, 2010

Compound progesterone
by: Wray

Hi Kim. I think you'll find the reason you're not feeling all that good is the oestrogen. Please consider using only the progesterone and see how you feel. I do hope the 100mg is not oral progesterone, this is the least effective delivery system. Most of it is destroyed as it passes through the gut and liver. If it is, and it's in an oil filled capsule, rather use it as a suppository/pessary. You will get the full benefit then. Take care, Wray

Apr 22, 2010

Estrogen is a must for us
by: Annie

To those of you going thru the hysterectomy process, take it from a 56 yr. old, do not forget to take the estrogen, especially if you are married. I had a hysterectomy in May of 2000, 3 wks shy of ten years now. Took 1.25mg estrogen for a few months. Quit because I had angina, abnormal EKG, and weight gain. Have been in frighteneing pain over the last month. Could not even walk at times. Vagina prolapsing, bladder incontinence, pubic osteitis, and intercourse impossible. But, I do have a normal EKG! I still have a cervix, but no ovaries. Had no children of my own. I received .750mg estrogen three days ago. My husband quit his OTR job to help me out. I pray things will get better. Please learn from this. Bless you!

Apr 24, 2010

Estrogen is a must for us
by: Wray

Hi Annie. Yes oestrogen is a must for us, but only small amounts. Oestrogen is a mitogen, it stimulates cells to grow, including fat cells, which in turn make oestrogen. It's vital during puberty when it causes our breasts and hips to develop, and the fatty layer women have. Vital once a month when it stimulates an egg/eggs to grow and mature. Vital too in stimulating the endometrium each month to grow and thicken ready for a possible fertilised egg.

But in excess it stimulates cells to continue growing, and grow they will with no progesterone to suppress the oestrogen. Our bodies must be kept in balance. But without a check, the excitatory hormones like oestrogen would continue stimulating. Oestrogen causes inflammation, as it stimulates matrix metalloproteinases (MMP?s), these are enzymes that break down protein. They play a role in the breakdown of endometrial tissues at the end of the menstrual cycle. If they are over active, as would be the case with excess oestrogen in the body, as oestrogen stimulates their production, the result is a pathological reaction. A high level of MMP?s can lead to inflammation and excessive bleeding in the uterus. High levels of both oestrogen and MMP's are found in arthritis and other autoimmune diseases. Progesterone suppresses both oestrogen and MMP's, it's also an excellent anti-inflammatory as it raises levels of IL-10 and other anti-inflammatory cytokines. There is always a risk in taking oestrogen, even bio-identical oestrogen, please see here and here. Take care, Wray

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Apr 24, 2010
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Submitted by: Wray

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Hi Annie. Yes oestrogen is a must for us, but only small amounts. Oestrogen is a mitogen, it stimulates cells to grow, including fat cells, which in turn make oestrogen. It's vital during puberty when it causes our breasts and hips to develop, and the fatty layer women have. Vital once a month when it stimulates an egg/eggs to grow and mature. Vital too in stimulating the endometrium each month to grow and thicken ready for a possible fertilised egg. But in excess it stimulates cells to continue growing, and grow they will with no progesterone to suppress the oestrogen. Our bodies must be kept in balance. But without a check, the excitatory hormones like oestrogen would continue stimulating. Oestrogen causes inflammation, as it stimulates matrix metalloproteinases (MMP?s), these are enzymes that break down protein. They play a role in the breakdown of endometrial tissues at the end of the menstrual cycle. If they are over active, as would be the case with excess oestrogen in the body, as oestrogen stimulates their production, the result is a pathological reaction. A high level of MMP?s can lead to inflammation and excessive bleeding in the uterus. High levels of both oestrogen and MMP's are found in arthritis and other autoimmune diseases. Progesterone suppresses both oestrogen and MMP's, it's also an excellent anti-inflammatory as it raises levels of IL-10 and other anti-inflammatory cytokines. There is always a risk in taking oestrogen, even bio-identical oestrogen, <a href="http://www.progesteronetherapy.com/13-years-on-bioidentical-hormones.html" target="_blank">please see here</a> and <a href="http://www.progesteronetherapy.com/hrt-research.html" target="_blank">here.</a> Take care, Wray

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