Total Cholesterol Reduced with Hormone Replacement to Youth Levels
by David G. Mills
(Memphis, Tennessee, USA)
As you know I have been taking progesterone now for a year and a half and I began to wonder if progesterone's precursor, pregnenolone, might have some significant relation to cholesterol levels.
Cholesterol is a 27 carbon molecule which metabolizes into 21 carbon progestens -- first progenenolone, then progesterone. Pregnenolone also metabolizes to DHEA. Progesterone then metabolizes to 21 carbon mineral and gluco cortcoids. Progesterone also metabolizes to 18 carbon androgens (testosterone being the main one) and the androgens metabolize to 17 carbon estrogens. Basically this is a progression of high carbon molecules downsizing into lower carbon molecules.
It occurred to me that high cholesterol levels might be the body's response to an improper balance of, or lack of pregnenolone, and/or progesterone. Thankfully, it occurred to other researchers as well. In these two studies, normalizing prognenolone, progesterone, DHEA and testosterone to youthful levels significantly brought down total cholesterol and specifically LDL (the "bad" cholesterol). That should not be surprising since pregnenolone is metabolized from LDL.
So here are the two studies done by the same primary researcher:
Once again I am going to be a guinea pig since my cholesterol is high, especially my LDL. So I will add pregnenolone and DHEA to my progesterone regimen and see what happens. I have two and a half months till I am due for my next cholesterol check.