Three miscarriages in one year

by cy
(uk)

I have had three miscarriages in one year. These occured between the 11th and 16th week. I have done all the tests and investigations, including a post mortem on the fetus, but nothing seemed wrong with me. I am so confused as my GP and gynaeclogist do not seem to help matters.

Do you think progesterone will be of help before and during my next pregnancy? What progesterone type, preparation and dosage should I use? Thanks.

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Three miscarriages in one year

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Dec 25, 2008

Progesterone
by: Anonymous

About 10 years ago, I also had two miscarriages... all within the first trimester of my pregnancies. I changed OB/GYNs and my new doctor sent me to a fertility specialist who had me start progesterone pills once I knew I was pregnant and to continue until my second trimester. And let me tell you, I am looking over at my nine-year-old daughter right now. I did have a lot of depression after the birth, and believe that I continue to have issues with low progesterone, i.e. depression, cysts in my breasts, low sex drive, etc... so here I am to fix myself.

See a specialist! It made all the difference for me!

Dec 29, 2008

Three miscarriages in one year
by: Wray

Hi Cy, yes I do believe progesterone will help you. It's strange you had all the tests and yet it seemed they didn't test for progesterone levels. This is an essential test if a woman is having recurrent miscarriages.

As for preparation, I prefer the cream to the other varieties available, as it can be applied anywhere. Studies have found it to be as effective as injections or suppositories, but far less painful than the one and more versatile than the other. I would recommend 200mg/day for the first 4 critical months. After that it would be up to you to either reduce the dose very slowly over the next month, or continue to term.

We do have a web page which gives more info, the link follows:

Can progesterone help with Conception and Fertility problems?
http://www.progesteronetherapy.com/faq-conception.html

Take care Wray

Jun 08, 2009

Can't explain this, confused?
by: cy

I wrote earlier, I had had 3 previous miscarriages between 11th and 16th week of gestation. I had a test done, but nothing seems wrong except for suspected antiphospholipid syndrome for which I was given aspirin, but that did not save my third pregnancy.

I got pregnant again in march 2009, so started progesterone immediately I confirmed this pregnancy. I had a scan at 6 weeks 5 days, everything was fine- the heart beat and the baby. My gynaecologist prescribed progesterone pessaries 200mg/day for the first 12th weeks and booked an appointmt for a scan, blood tests and extra prescription of progesterone for the next 1 month (meaning that I will be on progesterone for the first 4 months).

Everything was okay with the pregnancy,no pains, bleeding and I religiously took the aspirin, folic acid and progesterone. So I had another scan at 12 weeks 5 days (last Wednesday) and to my astonishment and disappointment, the baby was not found, just an empty sac. I couldn't believe it because I had no pains, bleeding and still felt pregnant. The scan said I possibly lost the pregnancy at about the 7/8 weeks. I had been advised to go for evacuation of retained products of conception, but I'm so confused as I still believe that my baby is alive.

Can anyone explain to me what went wrong and a possible explanation to my predicament? Thanks.

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Jun 08, 2009
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Submitted by: cy

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I wrote earlier, I had had 3 previous miscarriages between 11th and 16th week of gestation. I had a test done, but nothing seems wrong except for suspected antiphospholipid syndrome for which I was given aspirin, but that did not save my third pregnancy. I got pregnant again in march 2009, so started progesterone immediately I confirmed this pregnancy. I had a scan at 6 weeks 5 days, everything was fine- the heart beat and the baby. My gynaecologist prescribed progesterone pessaries 200mg/day for the first 12th weeks and booked an appointmt for a scan, blood tests and extra prescription of progesterone for the next 1 month (meaning that I will be on progesterone for the first 4 months). Everything was okay with the pregnancy,no pains, bleeding and I religiously took the aspirin, folic acid and progesterone. So I had another scan at 12 weeks 5 days (last Wednesday) and to my astonishment and disappointment, the baby was not found, just an empty sac. I couldn't believe it because I had no pains, bleeding and still felt pregnant. The scan said I possibly lost the pregnancy at about the 7/8 weeks. I had been advised to go for evacuation of retained products of conception, but I'm so confused as I still believe that my baby is alive. Can anyone explain to me what went wrong and a possible explanation to my predicament? Thanks.

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Jun 11, 2009

Can't explain this, confused?
by: Wray

Hi Cy. I'm sorry to hear of your miscarriage. I can't explain what went wrong, but there are a number of pointers.

You say you might have APS, was this not confirmed? Pointless giving you aspirin on a suspected possibility, so I assume you do have it. This would certainly account for the recurrent spontaneous miscarriages (RSA). Research has found levels of natural killer (NK) cells are higher in women with APS and RSA, as these are implicated in miscarriages, were your levels checked? Progesterone inhibits NK numbers and killing activity, so a low progesterone would allow these to become active.

Pro-inflammatory cytokines and TNF-α are higher in spontaneous abortions, indicating progesterone is low. But all this also suggests your antioxidant status is very low. I would recommend having your selenium, cysteine and glutathione levels checked, as these are always low in auto-immune conditions. Take care, Wray.