Severe anxiety manopause

by Sue

Nothing has helped. Antidepressants, or any of the things usually tried.

My thyroid is low I take Synthroid, I take something to help me sleep. But about 2 years ago it was like someone turned on a switch and my anxiety began. It gets unbearable. How long does it take for the progesterone cream to help? I am at my wits end.

Comments for Severe anxiety manopause

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Jun 25, 2010
Severe anxiety manopause
by: Wray

Hi Sue I don't know which cream you are using or how much progesterone it contains, but you should use between 100-200mg/day. But for severe anxiety you will initially need the higher amount, if not more. Please see our web page on Anxiety. There are many anti-anxiety nutrients, some of which are listed. Please have a vitamin D test done, a lack of this causes anxiety and depression, a low level also reduces the benefits of progesterone. There is more info on the anxiety page. It could be you have insulin resistance, an unstable blood glucose or a lack getting to the brain can cause anxiety/depression. This often starts during peri-menopause with dropping progesterone levels. IR has many causes, two are a lack of vitamin D and excess oestrogen. For more info please see our web page on Insulin Resistance. IR also causes the thyroid to slow down, but often the only problem is not with the thyroid but a lack of vitamin D. This raises parathyroid hormone which suppresses thyroid function. If you are using a small amount of progesterone I do advise increasing it, but before you do please see this web page on Oestrogen Dominance. It's best to use it daily, there is no need for a break. And no need either to only rub it on thin skinned areas. The skin comprises 95% kerotinocytes, these all have ample progesterone receptors. Take care Wray

Jun 25, 2010
by: Melissa

have you had a saliva hormone test to see where your levels are at for estrogen, progesterone, dhea, testerone?

This could be a very useful test to determine what's going on there.

Also I've read that low thyroid can be due to estrogen dominance..

The progesterone cream is good! Initally you may have more symptoms because the body is getting rid of the excess estrogen with the progesterone.. It's trying to balance itself out.

Another thing you might want to look into is DIM. This product is made from crufercious vegetables and help metabolize and get rid of excess estrogen.. it is safe and from what I read does not harm the thyroid.. since most people who have low thyroid are told to stay away from those kind of vegetables when they are not cooked because they can interfere with thyroid function. Here's an article I found with it.

Have you considered trying some nascent iodine to help with the thyroid issues? Like maybe a few drops a day?

Hope this helps!

Sep 28, 2010
by: Anonymous

I don't know how long you have been on the thyroid meds but i was put on synthyroid and had to get off of it due to heart beating to fast and heart would flutter was very nervous and juat felt awful like i was going to jump out of my skin. As soon as i winged off i started to feel better. I had rather be too low as to have to deal with that. The synthyroid was like poison to me.

Oct 02, 2010
Severe Anxiety
by: robyn

HI Sue .Have a look at this web site It has helped me a great deal .Just knowing what tests to ask for >The Dr's I have seen have no idea at all so it is important to know what tests there are and how to interpret them. I have been using progesterone for about a year now. Although I was very low in this hormone it didn't seem to help with my severe anxiety. I have Hashi's with my FT3 FT4 other levels still in the "normal range" with hypo symptoms so I started reading and discovered if your cortisol is low it can't transfer thyroid hormones to your cells. The thyroid hormones pool in the blood so when you have a thyroid blood test it can come back "normal'. This is if your Adrenals are fatigued. Worth considering. Good luck in figuring it all out.

Oct 06, 2010
Severe Anxiety
by: Wray

Hi Robyn Thanks for the link, it's a good site, I've used it myself for info. I'm not sure if you've had a vitamin D test done, but often a thyroid problem is nothing more than a lack of vitamin D. Please see here. The paper states... "The patients had relatively low levels of 25 OH Vitamin D: the average results (mean ± SD) were between 9.3 ± 4.4 to 13.7 ± 7.1 ng/mL in the different diseases, while the 25 OH Vitamin D concentrations less than 20 ng/mL are regarded as deficient." In fact 9.3 to 13.7 vitamin D falls into the deficiency category now, with authorities saying it should be a minimum of 50ng/ml. Please see the Vitamin D council website for more info. Dendritic cells are implicated in the initiation of autoimmune diseases, vitamin D inhibits their production, please see here.
Progesterone also inhibits dendritic cells, whereas oestradiol increases them, see here here. In all the autoimmune diseases I've looked at, a high level of oestrogen is observed. Oxidative stress is prevalent in autoimmune diseases too, including Hashi's, usually as a result of low vitamin D. High prolactin is implicated too, see here. Oestrogen stimulates prolactin production too, please see here. The prolactin/dopamine connection interests me, as excess prolactin suppresses dopamine, the converse is true. The precursor to dopamine is the amino acid tyrosine, if there is a lack of this amino or protein in the diet, dopamine drops and prolactin rises. Tyrosine is also the precursor to the two thyroid hormones T3 and T4. It's also the precursor to the two stress hormones adrenaline and noradrenaline, so demands on tyrosine are very high. Finally cortisol is made in the adrenals from progesterone, if the adrenals are stressed, production will be low. I've usually found progesterone excellent for anxiety, but it could be you need other nutrients too. Please see our page on Anxiety. Take care Wray

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