I have spent literally hundreds of hours researching the use of progesterone for the treatment of my fibroids,cyst, spotting,heavy bleeding,clotting,irregular cycles,insomnia, depression,anxiety,fatigue....and your website is the only one I've come across that advocates using such large doses of cream on a daily basis and without a break (if perimenopausal). Everything else I've read advocates using the minimal amount needed to address symptoms and feel better and stresses taking at least a three day break each month (unless menopausal). I have been following your advice and started using 160mg/day because I was under a great deal of stress and having severe anxiety and depression. I was also diagnosed with thyroid issues and am being treated for that. I'm feeling better and have reduced my daily dose to 100mg, but am still unsure about using without a break. I usually stop at day 27 and resume on day 7,but notice that I feel pre-menstrual and uncomfortable when I resume the cream. I do not know if I ovulate, but I don't think so. I used to "know" when I ovulated due to pain and pressure in my abdomen which I haven't felt in years. I am 52 years old and the past seven years have been horrible. I never thought I'd say this, but I hope I go through menopause soon! I guess I just want to make sure that using the cream in such large doses without a break is really okay - are there any studies you can direct me to that will give me the confidence to do that? Thanks for any advice you can give.