by Karen

I wanted to find out how many mg/gm are in your cream.

I just read on that for premenopausal women like myself I should use "15-24 mg/day for 14 days before expected menses, stopping the day or so before menses." Can you advise?

I also read, "Dr. Lee recommends that women avoid using higher than the recommended dosage to avoid hormone imbalances. More is not better when it comes to hormone balance." Can you let me know your thoughts?

I also read this on Dr Mercola's site ( "What happens, not only for progesterone cream, but for ANY hormone preparation you use by applying as a cream to your skin is that within a few weeks to a few months you will saturate the fat tissue with the hormones and they will actually stop working or can even make your symptoms worse.

The problem relates to the fact that progesterone is highly fat soluble and once applied to your skin will store itself in your fat tissue. When one initially uses the cream, there aren't any problems as the fat stores are very low. But as time goes on, the cream accumulates and contributes to disruptions in your adrenal hormones such as DHEA, cortisol, and testosterone. I have learned that although progesterone cream is an enormously useful tool, it needs to be used very cautiously.

I found that many of the women who were on the cream have terribly elevated levels of this hormone. Progesterone is normally a cyclical hormone and the body really needs to see a change in the concentration to affect a proper physiological response. If the level is constantly above the concentration that it recognizes as "off" or low, this is not possible.

Fortunately, this is repairable. But it may involve going off the cream for as long as two years to wash the progesterone out of your system." Can you advise? I feel very confused.

Thank you so much!!

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Aug 08, 2011
by: Wray

Hi Karen It can be confusing with so much contradictory info on the web and in books, not to mention varies doctors views! I've used progesterone cream for 15 years now, and not once have I found it saturates my fatty layer. Each time I've run out or experimented by using more, I've had Oestrogen Dominance symptoms. I think my receptors are still working fine! One thing which is always overlooked are the 100 and more oestrogen mimics in our environment, see Our Stolen Future. These can play havoc with our hormones, and the only safe way to counter them is by using progesterone. Testosterone will also suppress excess oestrogen, but with severe adverse effects in women. I've found levels of 100-200mg/day progesterone are needed, sometimes more if symptoms are severe. Low amounts merely exacerbate the oestrogen dominance symptoms. Although Dr Lee recommends 15-24mg/day, Dr Dalton would use up to 800mg/day, and 2400mg/day if her patients had post natal psychosis. She was outspoken about any study which found progesterone doesn't work, as she said the amount used was far too low. I've found the same, high amounts are needed if symptoms are severe. For instance over 1200mg/day is given via IV transfusion to brain trauma victims, simply because they needed it, see here and here. We often need high amounts too, especially if oestrogen or testosterone is high. Dr Mercola is now advising women use the cream in their vagina's, as this bypasses the 'fatty layer'. Plus there are many blood vessels which pick up the progesterone. I often recommend women use it there, it's excellent if any dryness or inflammation is present. Oestrogen exacerbates Candida, whereas progesterone is protective. So using it in the vagina is excellent if any fungal infection is present. Natpro is a 3.3% strength cream, each tube containing 2000mg. This means each g or ml contains 33.3mg progesterone. We do have more info on our page How to use progesterone cream. Scroll to the very bottom of the page, which gives the amount in ml and teaspoons. Take care Wray

Aug 28, 2011
by: Anonymous

Thanks so much!! Can you tell me how grams, mls and tsps equivalate?

Aug 30, 2011
by: Wray

Hi there 1 ml of water weighs 1 gram, and although the SG (specific gravity) of a cream is lower that that of water, it's very close. So I tend to use ml and grams as the same unit when measuring a cream. 1 tsp = 5ml. Take care Wray

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