Question concerning various forms of Vit D

by Charlotte
(Simpsonville, SC)

I had a vitamin d test back in 2007 which I thought the results were a bit odd and internet research didn't help with clarification.

My vit d3 was 20, vit d2 <4, 1,25 OhD was 58.

It seems my vitamin d levels are low but the kidney conversion is high. I have low renin hypertention, with a high aldosterone/renin ratio. This means I am salt sensitive.

In addition, I became extremely ill in the fall of 2005, couldn't lift my arms to fold a towel. Laid around. Went to 18 specialists. Found out the above information. Also in 2010 had a small blockage at the back of my heart while on HRT with pellets. I immediately stopped this. The HRT consisted of estrogen and testosterone pellets. I believe this is what cause the heart blockage. Just my opinion, as I am average height and weight, eat healthy, former health club owner also.

My FSH was very high, my doctor didn't believe the result. I went to my GP he did the same test, it came back high as well. For some reason they just didn't believe I was approaching menopause. I was 48! Also, in 2009, extremely insulin resistant. Blood insulin at fasting was 8 (that's good), after 75 g of glucose, insulin was 221 at last draw which was 2.5 hrs. later, blood sugar was 196 at same time. Pancrease working overtime.

These are just some of the things I have encountered. My story would be longer than anyone would care to read so I just hit the high spots. Any thoughts are welcome! Thanks!

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Mar 02, 2013
Question concerning various forms of Vit D
by: Wray

Hi Charlotte It's odd they even tested your 1,25 vitamin D as it's not normally tested unless one has something like sarcoidosis with elevated levels of 1,25 OHD. There is some evidence that low vitamin D i.e. calcidiol or 25-hydroxyvitamin D causes an increase in 1,25. It makes sense as the body works on a feedback system. And yours was extremely low. This could account for the hypertension, as low vitamin D stimulates the renin-angiotensin-aldosterone system. When you say you're salt sensitive, do you mean you need salt or avoid it? Aldosterone rises in an effort to retain salt, as sodium is vital to the adrenals. Angiotensin stimulates the secretion of the hormone aldosterone from the adrenal cortex. Aldosterone causes the tubules of the kidneys to increase the reabsorption of sodium and water. This increases the volume of fluid in the body, which also increases blood pressure. If the renin-angiotensin-aldosterone system is too active, blood pressure will be too high. Angiotensin is a potent vasoconstrictor of arterioles. Ironically drinking salt water can lower the BP, see here. Progesterone does inhibit aldosterone as it occupies the same receptor sites. It's an excellent diuretic too, given via IV transfusion to Traumatic Brain Injury victims. I find it extraordinary your doctors didn't know you were near Menopause! At 48 you are only 3 years away from the average age for it. 47-48 was when I was really hit by a multitude of unpleasant symptoms, although they had gradually built up from about 41, Peri-menopause is the pits! Luckily I found progesterone and they gradually went. Continued below

Mar 02, 2013
Question concerning various forms of Vit D Part 2
by: Wray

Hi Charlotte Pity about the pellets, I don't believe we need extra oestrogen and certainly not testosterone, see here, here, here, here here, here, here, here and here. And here and here too. Both oestrogen and testosterone cause Insulin Resistance. So too does a lack of vitamin D, plus this reduces the benefits of progesterone, see here, here and here. Please have a vitamin D test done and get your level up high. If you should consider progesterone I feel you would need nothing less than 200mg/day possibly more. Take care Wray

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