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question about luteal phase defect

by Lara
(North Carolina)

I am 43 yrs, female, trying to conceive but have luteal phase defect. About 10 or 11 days from ovulation to menses. I have been taking 100 mgs of oral progsterone but wanted to begin squeezing hormone(in olive oil) out of capsule and rubbing into skin. Pharmacist said she didn't think would work but I don't see how as the hormone in pills is same as they put in creams. Would you suggest I try and how much of the 50 mg pills should I use transdermally to correct my LfD? Thank you for your help!

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Feb 23, 2013
 question about luteal phase defect
by: Wray

Hi Lara It's far better to do your idea of emptying the contents of the capsule into some skin cream, and applying that. I often suggest it, it means you'll get the full benefit of the progesterone. Oral progesterone is the least effective Delivery system..... "The liver and gut region removed a mean of 96 per cent of the progesterone entering these tissues" see here. You might like to see this comment here. I would suggest using about 200mg/day, but it is trial and error to find the right amount. We also have a page on Pregnancy and another here you could look through. Please have a vitamin D test done, a lack of this reduces the benefits of progesterone, see here, here and here. It's vital for ovulation, conception, a successful pregnancy and breast feeding. there are some excellent videos on the pregnancy page about vitamin D and breast feeding, please have a look at them. Another nutrient you could consider taking is taurine, vital for the developing foetus, and for the new born, see here, here, here, here, here and here. Take care Wray
Feb 24, 2013
 applying cream internally
by: Lara

Wray: thank you so much for your response to me! This website is a godsend! Thank you!!

Can I insert the cream, hormone in oil inside my vagina? I have read this is an ideal situation for efficacy. What do you think and how exactly is the best way to do this internally?

Thanks again!

lara
Feb 25, 2013
 applying cream internally
by: Wray

Hi Lara Thanks for the kind words! The vagina is an excellent place to use progesterone, I apply some there every night. As you're using capsules you could just insert the capsule itself into the vagina. It will dissolve readily, in fact if you look on our delivery systems page you'll see one of the methods is vaginal caps, and the other system used are suppositories. A clean finger is the quickest and cheapest way if it's a cap or suppository. If it's a cream a finger works, some use syringes. Best if you do it only at night, as if done in the morning it can leak out. Unless it's put in the rectum then it doesn't leak. Take care Wray
Feb 25, 2013
 dosage to prevent miscarriage
by: Lara

Wray,
Would you recommend 200mg or more daily if I suspect my luteal issues may have caused me a past (unconfirmed but suspected due to pregnancy symptoms) miscarriage at time of normal menses? We have been trying for 10 cycles now and there are no other issues causing infertility that we know of except LFD. Would 200mg be enough to sustain pregnancy? Thank you again for taking time to help us!you're an angel!

Lara in NC
Mar 01, 2013
 dosage to prevent miscarriage
by: Wray

Hi Lara Bless you for the kind words! 200mg/day is the lowest amount I've come across to prevent miscarriages. The amounts have ranged from 200-600mg/day, there are papers about this on the pregnancy page. I firmly believe so called 'infertile' women aren't, but have a successful conception, possibly followed 2 weeks later by a miscarriage. Which is usually missed, as after all it's a 'normal' period. Unless there is a strong surge of progesterone prior to ovulation, followed by a strong surge after it, the embryo will fail to implant successfully. There's info and papers about this on the pregnancy page. This is why I recommend women trying to fall pregnant to use the progesterone during the 12 hour pre-ovulatory surge. Vitamin D is also essential for conception, please have a test done. Take care Wray
Mar 07, 2013
 how much prog. will stop menses?
by: Anonymous

Wray,
I am using 300 mg progesterone on my skin and vaginally. I have been doing this to lengthen luteal phase and to conceive. I am on day 28 of cycle and no period. This is late for me and unusual. I have low back and ovarian achiness but don't know if its PMS or pregnancy. I don't want to stop prog. Til I rule out pregnancy with blood test tomorrow day 29. My question is this: could this much prog 300 mg be holding off my menses even if I am not pregnant? Thank you so much for your help! Lara
Mar 09, 2013
 how much prog. will stop menses?
by: Wray

Hi Lara I've found the amount needs to be 400mg/day and over to stop bleeding, although some women need more than this. I suggest you continue with the progesterone, stopping too suddenly can cause a miscarriage. There's more info on our Pregnancy and here too. Don't forget that progesterone can upset the cycle when first using it, making it earlier or later than normal. If you're not pregnant your period will come eventually. And if you are you will have given a good boost to the beginning of the embryo's life. Let me know what transpires. Take care Wray

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