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Progesterone cream and heart palpitations

by Kelly

Several months ago I began having heart palpitations (heart skips) mainly after eating which were quite frequent and caused a lot of anxiety. I noticed that during my cycle the palpitations were the best-almost gone.

My doctor put me on progesterone cream (100 MG)-applying 1/2 to 1 gram depending on the day in my cycle (which I get at a compounding pharmacy). I am 46 years old. The palpitations went away almost immediately. Today (three months later) I started noticing them again even though I have been on the same dosage. In reviewing the past couple of days I remembered that when I picked up my last refill two days ago the compounding pharmacist told me that I needed to be rotating the cream and suggested my inner thighs (I was basically always doing it on my inner arms). I have read some articles where progesterone is best applied to thinner skinned areas of the body and I was wondering if my progesterone was not properly absorbed into my system when I was applying it to my (fatty) thighs??

Comments for Progesterone cream and heart palpitations

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Aug 16, 2011
 Palpitations
by: Anonymous

Wray says that it shouldn't matter whether you are applying it to the same area or not. Yes there is controversy but I would respect Wray's opinion. You could try applying it to the vaginal area because I believe it is best absorbed there.

Are you applying it twice a day and when you say you are applying 1/2 to 1 g depending on where you are in the cycle, can you give more information? Thank you,
Aug 16, 2011
 Progesterone cream and heart palpitations
by: Wray

Hi Kelly Progesterone can help palpitations. Oestrogen causes prolongation of the QT interval, which results in palpitations, arrhythmia and Torsades de Pointes. Whereas progesterone shortens the QT interval, see here, here, here, here and here. It seems possible that Oestrogen Dominance has occurred. You are in Peri-menopause too, so progesterone levels are dropping, it could be you are not using sufficient now. I recommend 100-200mg/day, dependant on symptoms. If you do increase the amount you're using, please read the page on oestrogen dominance as it can occur. Progesterone can be applied anywhere on the body. The skin comprises 95% kerotinocytes, which have ample progesterone receptors. I suggest you spread it around, it's excellent for the face too, see here. Take care Wray
Aug 16, 2011
 Amount
by: Anonymous

So does that mean you are using 50 to 100 mg progesterone depending on where you are in your cycle and when are you using 50 and when are you using 100 mg?

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