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progesterone and weight gain

by Debbie
(Canada)

I have wondered how many women out there have actually lost the weight of the hormonal imbalance after taking progesterone ..all I seem to do is gain weight all comments appreciated
thank you

Comments for progesterone and weight gain

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Feb 20, 2012
hormonal rush
by: muriel

you're right....read my page

Feb 20, 2012
Estrogen Dominance
by: CamperKat

Use the Google search bar on the left of this site, and type in "weight gain"...there are about 300 discussions of this, and you'll likely find info contained therein to be helpful.

And...any weight gain from using progesterone is because of estrogen dominance and it will eventually "go away"--type in "estrogen dominance", and you'll see what I mean.

Good luck to you.

Feb 21, 2012
Hi, Debbie
by: Mateja

Thank you, for asking this, Debbie. I am wondering about that, too. Before I begun with progesterone I was hoping that I will loose some weight but after 2,5 months on progesterone (250/mg) I gained another 15 pounds and still gaining.

Feb 21, 2012
Weight gain/Weight loss
by: Karenina

Hi Debbie,

The hormonal inbalance will have caused weight gain before you had started to use the Natpro Progesterone Cream. Once you use the N P cream you will gain weight initially due to Estrogen Dominance but when the progesterone kicks in you will begin to loose weight. I have seen it for myself. It will take time...Take care. Karenina

Feb 21, 2012
Weight loss??
by: Debbie

Thank you for you comments everyone any one else out there lost the weight and how long did it take

Feb 22, 2012
by Debbie
by: Wray

Hi Debbie You don't mention how much you're using. If it's the typical 20-40mg/day that will cause it. As both CamperKat and Karenina say it does go if enough is used, they both used very high amounts, Karenina still does. Put their names into the search field as CamperKat suggests, and you'll be able to follow their story, others too. Progesterone speeds metabolism, it can't cause weight gain. It's also an excellent diuretic, so prevents the water retention caused by oestrogen. There's more info about this on our TBI page. Please see our page on Oestrogen Dominance for more info on the weight gain. And for more info on How to use progesterone cream on this page. Take care Wray

Feb 22, 2012
Hi, Debbie
by: Wray

Hi Mateja I've corresponded with 3 other Mateja's from Slovenia, I'm not sure if it's the same one each time! Maybe you're the one with the asthma who also had weight gain? As I know I encouraged that one to increase to 250mg/day, but I've not heard back from her. Please have a vitamin D test done, and if low take 5000-10,000iu's per day. A low level reduces the benefits of progesterone. For more info on vitamin D levels, testing etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. You could also consider taking Calcium D-glucarate. Oestrogen is metabolised in the liver by glucuronic acid, the process is known as glucuronidation. Glucuronidation is one of the major detoxification pathways of the liver. It removes carcinogens, toxins, tumour promoters, the sex hormones ie, the androgens and oestrogens, mineralocorticoids and glucocorticoids, aromatic and heterocyclic amines, polycyclic aromatic hydrocarbons, various nitrosamines, drugs, fungi etc. It's then excreted in the bile, but an enzyme in the intestine called beta-glucuronidase reverses the glucuronidation process. It breaks the glucoronide bond between a toxin and glucuronic acid, and releases carcinogens, toxins and excess steroid hormones back into circulation. There's evidence beta-glucuronidase activity is increased in breast and prostate cancer. Calcium D-glucarate inhibits beta-glucuronidase, see here, here, here and here. Incidentally this enzyme is produced by undesirable gut bacteria, supplementing with probiotics suppresses the bacteria, and subsequently the beta-glucuronidase. And as CamperKat suggests please look around the site for other women with weight gain. Take care Wray

Mar 07, 2012
help what is happening
by: Debbie

All I do is get worse gained weight all over abdomne legs arms depressed +++ when will I see my body I am stopping this ...found out my estrogen is low low ...anything I can do to fast track what progesterone did
please anyone

Mar 09, 2012
help what is happening
by: Wray

Hi Debbie You still haven't told me how much progesterone you're using. If it's the usual 20-40mg/day then you will get gain weight. I gave you that page on TBI, the victims, mostly men, were given over 1200mg/day via IV transfusion. They did not get weight gain. When we're pregnant we can make over 400ng/ml per day, we don't put on extra weight. Only those women who's progesterone was low during pregnancy do. Some women use 1000mg/day, they don't put on weight. It's essential to use sufficient. Please let me know how much you're using. Take care Wray

Mar 10, 2012
Estrogen Dominance
by: Anonymous

Sorry for so many questions.
I read that if you use enough Natpro, you will avoid estrogen reaction. I am using 500 mg/day, but with that I didn't avoid problems. I would really like to know, what should I do? Should I use even more than 500 mg/day? For how long? Two months ago I started with Natpro because I wanted to feel better, but now I feel much worse and gained a lot of extra pounds.

About estrogen dominance: Does this mean that my body at this time is at greater risk of suffering from any serious disease (eg heart attack or cancer or anything like that?

About gaining weight: I read that if progesterone triggers estrogen, you gain weight, but only temporary. But I could not find anywhere, that someone actually lost that extra weight. As I understand term 'temporary', that means, it will disappear by itself. If I need some extra diet and more excercise, that doesn't mean, that gaining is temporary. It means, that it will probably stay forever.

I have never experienced so many problems when starting to use something for better health. But starting to use bioidentical progesterone cause so many problems that I am really very confused and sometimes I seriously doubt that I made the right decision.

Mar 11, 2012
Estrogen Dominance
by: Wray

Hi Debbie I don't mind how many questions you ask me, I'm here to help. And no, you are not at risk of getting any serious disease. The early days can be very difficult, even using high amounts as you are. I don't know what else is affecting you either. For instance do you eat or use any sugar, fructose or glucose or foods containing these sugars? Do you eat grains and legumes, as these both contain sugars, or the carbs they are made up of convert readily to glucose. Sugar in any form is the most damaging of all substances, as it leads to glycation. This causes oxidative stress, which in turn leads to Inflammation and advanced glycation endproducts (AGEs). We do have more info on our Nutrition page. I find the Paleo Diet the easiest to follow. Fructose, sucrose and glucose cause sex hormone binding globulin to decrease by 80, 50 and 40% respectively. This allows free testosterone and oestrogen to rise, which increases weight. In fact testosterone is notorious are causing visceral fat to increase, see here and here. Winter and dark gloomy days drop progesterone levels, large meals too. Excess phytoestrogens in food antagonise it. It's impossible to avoid the phytoestrogens, but the highest is found in grains and legumes. It could be your liver is not metabolising the oestrogen fast enough, or it enters circulation again. This can be avoided by taking calcium D-glucarate. Oestrogen is metabolised in the liver by glucuronic acid, the process is known as glucuronidation. Glucuronidation is one of the major detoxification pathways of the liver. It removes carcinogens, toxins, tumour promoters, the sex hormones ie, the androgens and oestrogens, mineralocorticoids and glucocorticoids, aromatic and heterocyclic amines, polycyclic aromatic hydrocarbons, various nitrosamines, drugs, fungi etc. It's then excreted in the bile, but an enzyme in the intestine called beta-glucuronidase reverses the glucuronidation process. It breaks the glucoronide bond between a toxin and glucuronic acid, and releases carcinogens, toxins and excess steroid hormones back into circulation. There's evidence beta-glucuronidase activity is increased in breast and prostate cancer. Continued below.

Mar 11, 2012
Estrogen Dominance Part 2
by: Wray

Hi Debbie Calcium D-glucarate inhibits beta-glucuronidase, see here, here, here and here. Incidentally this enzyme is produced by undesirable gut bacteria, supplementing with probiotics suppresses the bacteria, and subsequently the beta-glucuronidase. Silymarin from milk thistle also inhibits beta-glucuronidase, plus it helps the liver detox. Two women on this page, CamperKat and Karenina, both comment on weight lost after starting progesterone. You might like to also read these comments on weight loss reply to london and here. This is a very long page, put Jenine into control/find and you'll be able to follow the thread. And this one too on high amounts to feel well, see here. You might like to follow Annette on the website, she's been using progesterone for a year now, sometimes up to 1000mg/day or more. She also lives in Canada. This is one page here where she's made a comment. A woman called CL commented on this page too. She found it wasn't until she increased her vitamin D that her symptoms resolved. So please have a vitamin D test done. A lack of this nutrient reduces the benefits of progesterone. For more info on vitamin D levels, testing etc see the Vitamin D Council, GrassrootsHealth, Birmingham Hospital and Vitamin D Links websites. Blood levels should be 70-100ng/ml or 175-250nmol/L and not the 30ng/ml or 75nmol/L most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although the latest research indicates it should be 10,000iu's per day, see here. Take care Wray

Jun 03, 2013
weight gain
by: z0220e

I just began the progesterone cream today so I have not had any experience of weight gain as of yet. However, I live in fear of this happening. I am obsessive when it comes to weight gain and part of the reason I took a 28 day saliva test as well as a rather large amount of blood tested was to find out why I have gained 10lbs in the past year, as well as why I felt like I was losing my mind. I found out that my vitamin D was at a 20... So I am currently taking 10,000 IU of Vitamin D3. My saliva test showed that I am over the charts with progesterone when I am not supposed to be and when I am supposed to show it, it is almost non-existent. My estrogen levels are normal. I found out that I have luteal phase defect and this is why I have been having my period two times a month with each period lasting 12-14 days... This all began about 2.5 years ago. I turned 40 and within a year I had gained weight and my mood has been horrible. Depressed, angry, short temper, and at times even paranoia and extreme anxiety. I am a marathon runner and I go to bootcamps and various workout classes during the week. I watch what I eat, almost obsessively.. SO, I know myself. IF I keep reading that I am going to gain weight, I will not take the progesterone. I am sick of feeling the way I have been feeling though. I can say it was a relief to find out that I was not crazy after all, and that my hormones were in fact out of whack. My question to you is... does everyone who takes progesterone gain weight?

Jun 03, 2013
weight gain
by: z0220e

I just began the progesterone cream today so I have not had any experience of weight gain as of yet. However, I live in fear of this happening. I am obsessive when it comes to weight gain and part of the reason I took a 28 day saliva test as well as a rather large amount of blood tested was to find out why I have gained 10lbs in the past year, as well as why I felt like I was losing my mind. I found out that my vitamin D was at a 20... So I am currently taking 10,000 IU of Vitamin D3. My saliva test showed that I am over the charts with progesterone when I am not supposed to be and when I am supposed to show it, it is almost non-existent. My estrogen levels are normal. I found out that I have luteal phase defect and this is why I have been having my period two times a month with each period lasting 12-14 days... This all began about 2.5 years ago. I turned 40 and within a year I had gained weight and my mood has been horrible. Depressed, angry, short temper, and at times even paranoia and extreme anxiety. I am a marathon runner and I go to bootcamps and various workout classes during the week. I watch what I eat, almost obsessively.. SO, I know myself. IF I keep reading that I am going to gain weight, I will not take the progesterone. I am sick of feeling the way I have been feeling though. I can say it was a relief to find out that I was not crazy after all, and that my hormones were in fact out of whack. My question to you is... does everyone who takes progesterone gain weight?

Jun 05, 2013
weight gain
by: Wray

Hi z0220e Your symptoms are due to excess oestrogen, there's more info on our Oestrogen Dominance and Menstruation pages. From about age 35 we begin getting anovulatory cycles when we make no progesterone. This of course means oestrogen rises, and with nothing to counter it adverse symptoms occur. Anovulation increases in frequency through Peri-menopause until the ovaries stop producing viable eggs at Menopause. Oestrogen is a mitogenic, excitatory, inflammatory hormone. It stimulates cells, including fat cells, to proliferate, hence your weight gain. So yes, you will gain weight using too little progesterone, as it will stimulate oestrogen, it's essential to use enough. I normally recommend 100-200mg/day, but feel you will need at least 200mg/day. You might like to see these comments from high users, see here, here and here. We do have two more pages you could look through on Anxiety and Anger. Take care Wray

Nov 01, 2013
Actually lost weight
by: Anonymous

I started taking progesterone a week and a half ago. I've lost 5lbs. But I'm very active and I diet. I'm in the military so I do actually work out not just walk around the block. I had been 125 lbs most of my adult life, then all of a sudden gained 30lbs and lost my period. My doctor put my on progesterone and I feel awesome, I'm finally getting my symptoms under control and losing weight by the day!

Feb 11, 2014
Progesterone and weight gain.
by: Chelle

I have read many of your comments about too much estrogen causing weight gain.

I'm 47, have PCOS, I am also diabetic. I was having what is called peri-menopausal RAGE. I very up beat, friendly, laid back person until a 6 months ago and fits of rage started. So, my doctor put me on progesterone (oral) ... I love it... I'm calm and happy again... my old self. But this is month 4 on progesterone. Yep... I'm up 35 lbs. and still climbing.

How long do I have to wait to get more in balance with my estrogen and progesterone? Should I talk to my doctor about increasing my dose?

Any advise would be so appreciated.

Sep 06, 2014
Desperation
by: Chelsea

Hi,

My name is Chelsea and I am 24 years old. I have had a battle with hormones since I was 17 and put on the contraceptive pill for acne. Since then I have had issues including massive weight gains and subsequent losses when discontinuing the medication, as well as not getting my period back at age 21 when I came off the pill. After 2 years of not having it, a funiculi gynaecologist at my local hospital gave me a 5 week course of an oestrogen medication called progynova. In a year I have put on 10 kgs. I am small, only 5'2 and now weigh 65kg when I used to be 52-54. I have recently found a doctor who specialises in hormones and has prescribed me bio identical progesterone troche and DIM therapy to fix what he says is oestrogen dominance. I have been taking 1/4 troche in the morning and at night for 4 months. I believe this is 200mg in total. My breasts have increased 3 cup sizes and I have put on 5 more kgs in 4 months. I am desperately unhappy and in the last month have had suicidal thoughts. I need help. I have spoken with my boyfriend and we agree that this month I should come off the progesterone, and only take the DIM therapy to reduce oestrogen. When I started I had perfectly normal progesterone levels but my oestrogen was SO high in the luteal phase tests done on day 21 that my doctor said it was necessary to take progesterone to balance the oestrogen, which was probably caused from the progynova prescribed to start my period again. I am so young and building my first home. I should be happy and excited. As the days go on I feel worse, don't go out and see my friends and have had to take time off work. I need help. My doctor said to stop taking the progesterone until end of the year. People say that it gets worse before it gets better but honestly, intuitively, it doesn't feel like that. Doctors have always commented on how sensitive my body is to medication. Could it be that progesterone is just too much for me? Will the DIM work on it's own? I am at the end of my rope and need someone to help me. I eat a gluten and dairy free diet. Don't eat sugar or fruit due to a previous candida problem. I exercise. I have paraben free everything. What else can I do? What is happening to me? This month in particular has been the worse. My period only lasted two days. I'm so bloated, breasts are so large and my weight is at it's highest. Please help .

Sep 07, 2014
Desperation
by: Wray

Hi Chelsea I understand your desperation, I would be too. Unfortunately the progynova is behind all your weight gain. Oestrogen affects the thyroid adversely, which in turn affects our metabolism, it slows it down, see here. When starting progesterone it will stimulate oestrogen causing Oestrogen Dominance. It's essential to use enough progesterone to overcome this, but I can also understand your reluctance to continue. If you do, please don't use the troches, they are not the best Delivery system, much of it being swallowed and therefore destroyed by the gut. Please see our page on How to use Progesterone Cream. There is one thing I suggest you consider and that's a Ketogenic Diet. See also Solve Your Health Issues with a Ketogenic Diet and Low Carb Food List. Take care Wray

Nov 28, 2014
Mirena removal - estrogen dominant
by: Gigi

I recently had my Mirena removed after 8 months of pure hell on it (gained about 20 lbs, intense anxiety, depression, fatigue, hormonal acne, the list goes on...). I know for a fact that I am extremely estrogen dominant and suspect I have been for much of my life (been on birth control pills for the past 7 years). I read on your site that it's good to gradually intro progesterone cream before ending synthetic hormones but I'm past that point. I bought a natural brand of the cream today but am wondering how much you'd recommend for me coming off of such significant synthetic hormones. Can I expect to lose some of this extreme bloat and have more energy? How long does this typically take?

Dec 01, 2014
Mirena removal - estrogen dominant
by: Wray

Hi Gigi I'm sorry to hear you too had such a time with the Mirena. You might like to read other women's stories about it here. I only suggest adding the progesterone while using synthetic hormones to lessen the cold turkey affect. Your question is difficult if not impossible to answer. I usually recommend at least 200mg/day until stable. This might be sufficient, but it could be you need more, not until you try it out will you know. Please see our page on How to use Progesterone Cream. And I have no idea how long it will take, I wish I did. Some women respond quickly, others take 3-6 months, some are using high amounts for over a year, see here. One thing I would ask you to do is have a Vitamin D test done. A lack of this reduces the benefits of progesterone. Take care Wray

Dec 01, 2014
JUST CALL ME BLUBBER, BLUBBER, BLUBBER...
by: Anonymous

I started taking this progesterone in a pill format, as well as the estrogen called by the name of Estrace in a cream form, and I have not only put on 20 lbs, but its as if im wearing a massive whales blubber carcass around my massive gut, which i had a little bit before, but now after only three months I have not just one hand full of fat, but four or five in front of me and it goes all the way around my torso as well as my bum and thighs. these are new areas of weight gain for me. Additonally,my thighs calves, upper arms, have never been a problem but now.... I'm essentially holding massive amounts of inflammation and fluid everywhere, plus this whale sized "floatee" around my torso, under my chin, atop my atlas back bone and sitting right down atop my pubic bone??? I can't tell you how DEVASTATED I HAVE BECOME! MY FIGURE IS GONE FOREVER! I don't even want to leave the house, I'm so shocked and embarrassed. I used to be able to work out 3 hours a day for 5-6 days a week, my whole life, until I was 42 when i got very sick and really haven't recovered from the pain and acute and chronic fatigue, (im now 50) and then my vitamin D starts dropping to negligible amounts (@ 10 or less) about 8 YRS Ago and continues to drop? Then my thyroid and adrenals both took a crap...leading to a FULL SET OF HORMONE PROBLEMS, AND NOW MASSIVE WEIGHT GAIN, WHICH IS SO OUT OF CONTROL, MY DOCTORS ARE CONCERNED FOR MY HEART and now Diabetics...never HAD SO MANY HORMONE ISSUES. Ive NEVER had loads of fat around my gut, like this, in this amount, EITHER??? I don't know what to blame it on? Is it all the hormones, THE D DEFICIENCY or is this some kind of disease? My gyno says by putting me on all these synthetic hormones, I will eventually balance out in 4-6 months, but i will officially be over `100 lbs heavier by then, and the level of body fat, alone, will be enough to have whaling boats after me! I will need massive lipo suctioning just to be able to walk. I am already waddling! not kidding. I used to be a body builder with a size 6-8 size cloths, but now a massive 16. DOES ANYONE HAVE ANY ANSWERS BESIDES THE USUAL QUICK FIX COMMERCIALLY MARKETED BOTTLE OF PILLS???
IF THIS IS FOR SENDING ME MARKETING PLEASE DELETE THIS And take my name off this site.

Jan 31, 2015
Progesterone Weight Gain!
by: Kelly H.

I have been on bioidentical progesterone for over one year now - I have taken 100mg tablet and 10mc cream and three weeks on and one week off (i even tried to stop 12-15 days to mimic my cycle) I am very very unhappy with the weight gain. When I started in June 2013 I weighed only 118 lbs and today January 2015 I now weigh 145 lbs - this is BS! I have always had the tiniest waist and flat stomach, I've never had children so I've never had a pouch. I'm a former powerlifter on the national level so I've always had great muscle tone. I cannot stand being fat now, I'm at my breaking point, I'm quitting this stuff cold turkey and I hope to heck I get my tiny frame back. I hate this stuff!

Dec 05, 2015
ugg fat now
by: Anonymous

hello i originally started on progesterone cream at 50mg but quickly dropped down because of all the weight i went down to 20mg and have been on 20 mg progesterone cream for 2 years, shortly after i started it i began packing on the weight. my weight initially was 125 at 5'5 height athletic build and within 1 year aftr i started i was up to 155 and now im at 165, and i eat less then i ever have. If i dont take cream i feel like shit if i do take cream the result is alot of weight and my estrogen levels are normal so im not sure its an estrogen dominance reason. Heading back to Gyn see if theres any other answers. so yes definetly a high weight gain drug

Jan 03, 2016
Getting Off Progesterone - Do you lose the weight back
by: Anonymous

There are lots of comments on weight gain here from progesterone therapy and I have the same issue. I just went off this week. Did anyone lose back the weight they gained from it? How long did it take?

Apr 18, 2016
300 mg oral bio-identical progesterone
by: Laura

I really wish I had an answer, but after 18 months on 300 mg oral bio-identical progesterone, I am FAT, FAT FAT, where once I was slender, and it is an awful feeling to be bulging where once was slimness.

I take no estrogen, either. 300 mg progesterone = FAT. I walk, I eat low-carb, and still I am FAT for the first time in my life.

Aug 07, 2016
Trying to get the progesterone weight off!
by: Anonymous

Hello,

I was told to take progesterone and esterdiol when the dr saw my saliva test results. I was a little low in testosterone and progesterone and my cortisal was through the roof = adrenal fatigue. I took the hormones and gained weight within just a few weeks. I felt better at first but then my symptoms became worse...not being able to sleep, moodiness, anger etc. I weened myself off the hormones and started taking pituitrophin and adrenal desiccated for my pituitary and adrenals. I fell AMAZING. I'm back to my old self, happy, relaxed, laid back...my boyfriend said as soon as I stopped the hormones and got on the glandular that he noticed a Huge change in me, Im back to myself. And have felt more myself since started the glandulars. Man what a difference! Please see about addressing your adenal thyroid and pituitary which make hormones like progesterone and testosterone etc. my hormones are back to normal but I'm working out 1-2 x's a day (serious muscle building and HIIT cardio and hot yoga) and want to know when I'll get my body back?! I'm in the fitness and health industry and it's important for me to look healthy and fit. Just less than two months ago, I had 16% body fat and weighed 118...now there's a jelly belly and massive hips and My clothes don't fit me anymore. Please help. Will the weight come off??

Jul 20, 2023
Help mother of 7 fibroids and progestone cream dosage
by: Leah

Hello I have been blessed to give birth to 7 children. I had them all via c-section and have suffered some consequence. As of now I am 39 and numbers from test suggest pre meno pause and fibroids. My period are heavy and filled with large clots. My dr told me to take progesterone for the first 7 days of cycle to shed lining more quickly but this is not help clots. I have read you can take from day 7-27 of cycle to regulate period and hormones. I am currently taking 20 mg of progesterone cream and wondered if I should take more?? I am also still carrying 20-30lbs and will lose and gain the same weight very quickly, even though i exercise 4-5 days a week annd eat a very strict diet

Jul 21, 2023
Help mother of 7 fibroids and progestogen cream dosage
by: Joy

Hi Leah

You are in Peri-Menopause which usually starts at around 35. This is a time when heavy/continual bleeding and clotting takes place. The monthly cycle also becomes erratic.  Your doctor is so uninformed unfortunately.  Nothing less than 100mg per day is required. The amount that your doctor advised will aggravate your estrogen receptors, please read Estrogen Dominance. I can never understand why doctors do not know that.  Natpro progesterone cream (not oral) should be used every day with no breaks at all.  Usually between 100-200mg per day is needed.  Half the amount in the morning and the other half at night.  However, you are dealing with clotting etc, please consider trying the following protocol which will help you.  Once the clotting etc has stopped the cream can be slowly  reduced to no less than 100mg per day.  Please read How to use Progesterone Cream.

Heavy Bleeding Protocol
400-500mg Natpro Progesterone Cream per day
2000mg N-Acetyl-Cysteine (NAC) per day
2000mg Taurine per day
5000iu's Vitamin D3 per day
1000mg Bioflavanoids per day

Fibroids are due to oxidative stress, you need to address the Inflammation that you have. Fermented/cultured foods will help with this. They are the best probiotics, better than any OTC ones. Fibroids possibly also caused by the C-sections that you had.

Your weight gain could be caused by Insulin Resistance and thyroid issues. Have these been tested?  The 20mg progesterone advised by your doctor will also cause weight gain.

What is your Vitamin D3 level? A deficiency will reduce the benefits of progesterone.  It is connected to every single function cell in our bodies, making it vital as are the cofactors mentioned.  

All the best.

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