Progesterone and vitamin D references

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Please note: The following papers are a selection covering the similarities between the two hormones.

Adv Biomed Res 2012, 1:58
Comparison of the administration of progesterone versus progesterone and vitamin D in improvement of outcomes in patients with traumatic brain injury: A randomized clinical trial with placebo group

VDC December 18, 2012
RCT: Vitamin D levels and traumatic brain injury

Lupus April 2012 vol. 21 no. 5 477-484
Vitamin D status in systemic lupus erythematosus patients and its association with selected clinical and laboratory parameters

ScienceDaily (Mar. 31, 2012)
Oral Vitamin D Supplements Reduced Levels of Ki67 in Prostate Cancer Cells

Acta Paediatr. 2012 Feb 28
Depressed adolescents in a case-series were low in vitamin D and depression was ameliorated by vitamin D supplementation

Eur J Endocrinol. 2012 Jan;166(1):77-85
Association of hypogonadism with vitamin D status: the European Male Ageing Study

Diabetic Medicine Volume 29, Issue 1, pages 4349, January 2012
Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes?

Diabet Med. 2012 Jan;29(1):50-5
Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES

BMC Biochemistry 2011, 12:5
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

Epilepsy December 5, 2011
Phase III Progesterone Therapy Trial For Women With Epilepsy Has Favorable Outcome

Arch Biochem Biophys. 2011 Mar 15;507(2):241-7
1,25-Dihydroxyvitamin D suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-B activation

Curr Neurol Neurosci Rep. 2011 Aug;11(4):435-42
Hormonal therapy for epilepsy

Neurol Sci. 2011 May;32 Suppl 1:S31-5
Female reproductive steroids and neuronal excitability

Medical Practice and Review Vol. 2(1), pp. 11-15, February 2011
Association of serum vitamin D level with diabetic polyneuropathy

Cancer Epidemiol. Biomarkers Prev. January 1, 2011 20:187-198
Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort

VDC October 4, 2011
Vitamin D in diet and depression

Am J Clin Nutr. 2011 Oct;94(4):1104-12
Vitamin D intake from foods and supplements and depressive symptoms in a diverse population of older women

Steroids. 2011 Aug;76(9):845-55
Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity

VDC 16 August 2011
Mental health and learning disorders

Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):7-14
Vitamin D, neurocognitive functioning and immunocompetence

Med Hypotheses. 2011 May;76(5):643-5
Can vitamin D delay the progression of ALS?

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13409-14 Microaerobic steroid biosynthesis and the molecular fossil record of Archean life

J. Nat. Prod., 2010, 73 (3), pp 338345
Occurrence of Progesterone and Related Animal Steroids in Two Higher Plants

ScienceDaily (Feb. 4, 2010)
First Discovery of the Female Sex Hormone Progesterone in a Plant

Evolution. 2010 Jul;64(7):2179-83 Cholesterol as an evolutionary response to living with oxygen

PNAS June 29, 2010 vol. 107 no. 26 11859-11864
Conservation of progesterone hormone function in invertebrate reproduction

American Journal of Pathology April 2, 2010
Vitamin D Receptor Negatively Regulates Bacterial-Stimulated NF- B Activity in Intestine

J Am Geriatr Soc. 2010;58(11):2063-2068
A Randomized Controlled Trial of the Effects of Vitamin D on Muscle Strength and Mobility in Older Women with Vitamin D Insufficiency

Neuropharmacology. 2010 Dec;59(7-8):573-81
Disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis

Endocrinology 2010, Vol. 151, No. 10 4654-4664
GADD45 : a New Vitamin D- Regulated Gene that Is Antiproliferative in Prostate Cancer Cells

Med Hypotheses. 2010 Jan;74(1):158-61.
Benefits of sunlight: vitamin D deficiency might increase the risk of sudden unexpected death in epilepsy

The Journal of Pediatrics 17 March 2010
High Prevalence of Vitamin D Deficiency among Inner-City African American Youth with Asthma in Washington, DC

Free Radic Biol Med. 2009 Sep 15;47(6):880-9 Special relationship between sterols and oxygen: were sterols an adaptation to aerobic life?

Differential Modification of Progesterone in TNFalpha-induced Cyclooxygenase-2 (COX-2) and Manganese Superoxide Dismutase (Mn-SOD) Expression in Human Endometrial Stromal Cells

J Reprod Immunol. 2009 Jun;80(1-2):91-9
Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery

J Reprod Immunol. 2009 Jul;81(1):17-24
Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts

Neurobiol Aging. 2009 May 29
Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats

Eur J Endocrinol. 2009 Oct;161(4):575-82
Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome

Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S265-77
Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases

Br J Cancer. 2009 Feb 10;100(3):450-4
Association between serum 25(OH)D and death from prostate cancer

Journal of Clinical Oncology, Vol 27, No 23 (August 10), 2009: pp. 3757-3763
Prognostic Effects of 25-Hydroxyvitamin D Levels in Early Breast Cancer

Mol Med. 2009 Sep-Oct;15(9-10):328-36
Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone

Front Neuroendocrinol. 2009 Jul;30(2):158-72
Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease

Front Neuroendocrinol. 2009 Jul;30(2):173-87
Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration

Brain Behav Immun. 2009 August; 23(6): 750754.
Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women

Nat Rev Cardiol. 2009 Oct;6(10):621-30
Vitamin D status and arterial hypertension: a systematic review

Curr Opin Allergy Clin Immunol. 2009 Jun;9(3):202-7
Childhood asthma may be a consequence of vitamin D deficiency

American Journal of Respiratory and Critical Care Medicine Vol 179. pp. 765-771, (2009)
Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica

Neurobiol Aging. 2009 May 29
Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats

Journal of Perinatal Medicine 24/11/2008
Progesterone induced blocking factor (PIBF) and Th1/Th2 cytokine in women with threatened spontaneous abortion

Frontiers in Bioscience 13, 985-994, January 1, 2008
Cytokine imbalance in pregnancy complications and its modulation

Circulation. 2008;117:503-511
Vitamin D Deficiency and Risk of Cardiovascular Disease

Medscape February 11, 2008
Vitamin D Appears to Cut Breast and Colorectal Cancer Risk

Steroids. 2008 Aug;73(7):738-50
Progesterone metabolites rapidly stimulate calcium influx in human platelets by a src-dependent pathway

Arch Gen Psychiatry Vol. 65 No. 5, May 2008
Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults

J Am Coll Cardiol, 2008; 52:1949-1956
Vitamin D Deficiency

Bone. 2008 May;42(5):996-1003
Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D

Am J Clin Nutr. 2008 Apr;87(4):1080S-6S
Vitamin D deficiency: a worldwide problem with health consequences

Pharmacol Ther. 2007 Oct;116(1):77-106
Progesterone: therapeutic opportunities for neuroprotection and myelin repair

Biochem Biophys Res Commun. 2007 Nov 30;363(4):885-8
Sterol biosynthesis and prokaryotes-to-eukaryotes evolution

BMC Evolutionary Biology 2007, 7:222
Functional evolution of the vitamin D and pregnane X receptors

J Allergy Clin Immunol. 2007 Nov;120(5):1031-5
Is vitamin D deficiency to blame for the asthma epidemic?

Mediators Inflamm. 2007; 2007: 93431
Progesterone Prevents Traumatic Brain Injury-Induced Intestinal Nuclear Factor kappa B Activation and Proinflammatory Cytokines Expression in Male Rats

J Bone Miner Res. 2007 Dec;22 Suppl 2:V50-4
Vitamin D insufficiency/deficiency in gastrointestinal disorders

Circulation. 2007;116:2913-2922
Progesterone Regulates Cardiac Repolarization Through a Nongenomic Pathway

Endocrinologist: November/December 2007 - Volume 17 - Issue 6 - pp 319-325
Is Vitamin D Insufficiency Associated With Peripheral Neuropathy?

Journal of Neuroscience Research 2007 Volume 85 Issue 11, Pages 2441 - 2449
Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants

Life Sciences Volume 81, Issue 3, 27 June 2007, Pages 188-197
Gender specific effect of progesterone on myocardial ischemia/reperfusion injury in rats

Maturitas. 2007 Oct 20;58(2):117-37
Vitamin D and its implications for musculoskeletal health in women: an update

Pharmacol Rev. 2006 Dec;58(4):742-59
The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor

1: Exp Clin Endocrinol Diabetes. 2006 Nov;114(10):577-83
Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome

TheScientificWorldJOURNAL (2006) 6, 125139
Vitamin D as a Neuroactive Substance

Endocrinology. 2006 Apr;147(4):1997-2007
Fetal Programming- Prenatal Testosterone Treatment Leads to Follicular Persistence/Luteal Defects; Partial Restoration of Ovarian Function by Cyclic Progesterone Treatment

Clin Calcium. 2006 Jul;16(7):1173-79
Vitamin D-vitamin D receptor system regulates antithrombogenicity in vivo

Pacing and Clinical Electrophysiology Volume 29, Issue 6, pages 607613, June 2006
Influence of Menstrual Cycle on QT Interval Dynamics

Endocrinology 2005, Vol. 146, No. 2 736-743
Progesterone Antagonizes the Permissive Action of Estradiol on Tumor Necrosis Factor- -Induced Apoptosis of Anterior Pituitary Cells

GIT 2005-06-27
The Effect of Progesterone Withdrawal on Molecular and Behavioral Indices after Traumatic Brain Injury

Br J Dermatol. 2005 Sep;153(3):626-34
Effects and side-effects of 2% progesterone cream on the skin of peri- and postmenopausal women: results from a double-blind, vehicle-controlled, randomized study

Cancer Causes and Control 16: 8395, 2005. 83
The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)

Neuroscience. 2004;125(3):605-14
Progesterone up-regulates neuronal brain-derived neurotrophic factor expression in the injured spinal cord

J. Nutr. 134:1299-1302, June 2004
The Discovery of Vitamin D: The Contribution of Adolf Windaus

Growth Hormone & IGF Research Volume 14, Supplement 1, June 2004, Pages 18-33
Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination

Med Hypotheses. 2004;63(2):250-3
1alpha,25-dihydroxy-vitamin-D3 as new immunotherapy in treatment of recurrent spontaneous abortion

Journal of Cellular Biochemistry 88:296307 (2003)
Vitamin D: A Millenium Perspective

Recent Results Cancer Res. 2003;164:3-28
Evolution and function of vitamin D

Journal of Cellular Biochemistry Volume 88, Issue 2, pages 327 331, 1 February 2003
Vitamin D regulation of the reninangiotensin system

Endocr Rev. 2002 Oct;23(5):687-702
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

The Journal of Immunology, 2002, 168: 1087-1094
Direct and Indirect Inhibition of Th1 Development by Progesterone and Glucocorticoids

European Journal of Neuroscience Volume 16 Issue 1 Page 169 Issue 1 - 173 - July 2002
The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens

The Journal of Physiology, 544, 511-520 October 15, 2002
Progesterone reverses the neuronal responses to hypoxia in rat nucleus tractus solitarius in vitro

Hum. Reprod. (2002) 17 (6): 1459-1463
Luteal phase progesterone excretion in ovulatory women with polycystic ovaries

Trends in Endocrinology and Metabolism Volume 13, Issue 3, 1 April 2002, Pages 100-105
New clues about vitamin D functions in the nervous system

Hypertension. 2001;37:142
Vascular Effects of Progesterone

Crit Care. 2001 Dec;5(6):343-8
Gender-related plasma levels of progesterone, interleukin-8 and interleukin-10 during and after cardiopulmonary bypass in infants and children

AJP - Regu Physiol February 2001 vol. 280 no. 2 R488-R493
Relationship of ovarian hormones to hypoxemia in women residents of 4,300 m

FrontiersinNeuroendocrinology 21,156(2000)
Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators

Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Sep;1(4):283-6
Treatable lower motor neuron disease due to vitamin D deficiency and secondary hyperparathyroidism

Hum Reprod. 2000 Jun;15 Suppl 1:46-59
Progesterone inhibits in-vitro embryotoxic Th1 cytokine production to trophoblast in women with recurrent pregnancy loss

Neuroendocrinology 2000;72:133-143
Progesterone Prevents Estradiol-Induced Dendritic Spine Formation in Cultured Hippocampal Neurons

Steroids. 1999 Jun;64(6):430-5
Vitamin D and calcium dysregulation in the polycystic ovarian syndrome

The Journal of Clinical Endocrinology & Metabolism 1999, Vol. 84, No. 1 265-271
Two Antiatherogenic Effects of Progesterone on Human Macrophages; Inhibition of Cholesteryl Ester Synthesis and Block of Its Enhancement by Glucocorticoids

The Journal of Immunology, 1998, 160: 5098-5104
Regulation of TNF-alpha Production in Activated Mouse Macrophages by Progesterone

Gynecol Endocrinol. 1998 Feb;12(1):29-34
Effects of estradiol and an aromatase inhibitor on progesterone production in human cultured luteal cells

Hum. Reprod. (1998) 13 (2): 290-293
Polycystic ovary syndrome: anomalies in progesterone production

J Microbiol Immunol Infect. 1998 Sep;31(3):197-9
Premenstrual asthma: report of a case with hormonal studies

Mol Chem Neuropathol. 1997 May;31(1):1-11
Progesterone protects against lipid peroxidation following traumatic brain injury in rats

Int J Vitam Nutr Res. 1996;66(1):39-45
Comparative effectiveness of vitamin D3 and dietary vitamin E on peroxidation of lipids and enzymes of the hepatic antioxidant system in Sprague--Dawley rats

CALCIFIED TISSUE INTERNATIONAL 1995, Volume 57, Number 6, 436-441
Progesterone receptors are expressed in human osteoblast-like cell lines and in primary human osteoblast cultures

Journal of Neuroendocrinology Volume 7, Issue 3, pages 171177, March 1995
Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABAA Receptors

Reproductive Sciences October 1994 vol. 1 no. 4 302-309
The Anabolic Effects of Progesterone on Fetal Rat Calvaria in Tissue Culture

International Journal of Epidemiology 1990, Volume19, Issue2Pp. 297-302
Relationship of Menopausal Status and Sex Hormones to Serum Lipids and Blood Pressure

The Lancet, Volume 332, Issue 8607, Pages 370 - 372, 13 August 1988

Brain Res. 1987 Jan 6;400(2):353-9
Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action

Br Med J 1974;2:258-259 (4 May)
"Anticonvulsant Action" of Vitamin D in Epileptic Patients? A Controlled Pilot Study

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