Progesterone and tooth decay

by Cindy

Hi Wray, I was reading on Wikipedia about Progesterone and one thing it said was "It may affect gum health, increasing risk of gingivitis (gum inflammation) and tooth decay." Yikes is this true ?

Comments for Progesterone and tooth decay

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Feb 05, 2011
Tooth decay and Insullin Resistance
by: Cindy

Hi Wray here is another topic I wonder about on Wikipedia "Current research suggests that progesterone plays an important role in the signaling of insulin release and pancreatic function, and may affect the susceptibility to diabetes.[36] It has been shown that women with high levels of progesterone during pregnancy are more likely to develop glucose abnormalities.[37]" Does this also mean women in menopause can come down with insulin resistance if using Progesterone in cream form , I read through the whole page http://en.wikipedia.org/wiki/Progesterone , to make sure I read it right for both issues this one and the one about tooth decay. I have been using NatPro for a month now I really like the cream its very nice to use. I'm hoping you can shed some light on these two things for me as.

Feb 07, 2011
Estrogenic Ingredients
by: Cindy

Hi Wray Cindy here and I'm wondering if some of the skin care products I use could be estrogenic . Do you have a recent list of estrogenic offenders in skin care products ? Right now I'm using a product line called Isomers and one of the products are called R Pur for face and eyes and it contains water Glycine Soja (Soybean) Germ Extract, Oleyl Alcohol, Dioscorea Villosa (Wild Yam) Root Extract, Glycine Soja (Soybean) Sterols, Glycine Soja (Soybean) Lipids, Glycine Max (Soybean) Symbiosome Extract, Glycine Soja (Soybean) Sprout Extract, Glycerin, Glycine Soja (Soybean) Seed Extract, Soy Lecithin, Sodium Hyaluronate, Whey Protein, Lysolecithin, Tetrahydropiperine, Phenoxyethanol, Tropolone. I'm thinking these ingredients are estrogenic but don't know if they would interfere with my Progesterone therapy ? I do seem to be having some physical and emotional issues lately and I just started this product a week ago .

Feb 07, 2011
Is this true
by: Anonymous

I don't see how this could be true. Did it give the anatomical reasons?

Feb 09, 2011
Not sure what to think
by: Anonymous

I found both topics on this website I don't know if this is true but if we believe all the positive things said there then we can certainly wonder about these two negatives I pointed out. Who knows I may be understanding it wrong. http://www.progesteronetherapy.com/progesterone-and-tooth-decay.html

Feb 18, 2011
Progesterone and tooth decay
by: Wray

Hi Cindy I've not heard that progesterone can increase ginginvitis or tooth decay. One wonders if this is the case, why all pregnant women, including all pregnant female animals, don't have decayed teeth at the end of pregnancy! In women, progesterone rises from 5-20ng/ml produced during the luteal phase to over 400ng/ml in the third trimester. The Wiki page gives no reference to a study on this. I've looked through 8 pages of studies on Google scholar and found only one article, not a study. It made me laugh, as it said "Progesterone dilates blood vessels causing inflammation, and blocks the repair of collagen, the structural protein that supports the gums." How a dilating blood vessel can cause inflammation I don't know. Progesterone is a potent anti-inflammatory, it stimulates the Th2 cytokines. As for blocking the repair of collagen, the reverse is the case, see here and here. Take care Wray

Feb 18, 2011
Tooth decay and Insullin Resistance
by: Wray

Hi Cindy I've read both papers, the first a hugely complicated study, where all the progesterone receptors were removed, or 'knocked out'. This lead to the conclusion that the mice had an improved glucose homeostasis. Pity they didn't knock out all the oestrogen and testosterone receptors too! Only a small fraction of women get gestational diabetes, if progesterone was the guilty party, surely the level would be far greater, if not all women coming down with it? I'm more convinced by the following papers here, here, here, here, here, here, here, here and here. There is now increasing evidence that testosterone and oestrogen are the guilty parties, see here, here, here, here here, here and here. More on insulin resistance here. In this paper they say obesity is the most common cause of insulin resistance. This is like putting the cart before the horse. Particularly as there is strong evidence IR and diabetes are epigenetic diseases starting in utero, see here. There is evidence a lack of vitamin D causes gestational diabetes, see here. Finally a lack of vitamin D reduces the benefits of progesterone. Pleased you like the cream! Take care Wray


Feb 18, 2011
Estrogenic Ingredients
by: Wray

Hi Cindy Soy has oestrogenic properties. The skin absorbs everything we put on it, unless the molecule is too large to pass through. Another caution, much of the soy we use is GM, and soy production is partly responsible for the destruction of the rain forests. Maybe the product states it's from organically grown soy? EWG have an excellent site, with a search field for all cosmetic ingredients, see here. I've already inserted into the search field the preservative phenoxyethanol. Delete this when looking up the other ingredients. For more info on soy please see here. Take care Wray

Feb 18, 2011
Hip Pain
by: Cindy

Hi Wray and thank you for your response I read all the links. I'm on about 300mg of NatPro now divided up through out the day and will be reducing slowly pretty soon. I started on Jan 1st to make it easier to track and as a New Years resolution to improve my health. I'm just recently starting to experience an intensive increase in my left hip pain from my arthritis since I increased my Progesterone cream several days ago to help over ride stress and symptoms that come and go as my first 3 months progress. I was on 200mg a day divided between morning and evening prior to that. Is the severe hip pain a result of the increase and will it subside if I do stay at 300mg or what might you suggest ? Also since I started pro cream I have gotten very ill on two occasions the flu and a bad cold. Prior to starting progesterone I virtually never got sick and haven't had a cold in maybe 7 years. I've taken vit D3 for years at 7200iu a day and this past December I increased it to 10,000iu a day. I just wonder how this could be as I have always had stress so that's nothing new. Got any input ? Thanks

Feb 20, 2011
Hip Pain
by: Wray

Hi Cindy I'm pleased the papers I gave you reassured you enough to continue! Yes the pain is due to increasing the amount. This paper gives evidence of progesterone's anti-inflammatory effects, see here and here. It happened to me last year, my nails were flaking and peeling, it took me 3 months to realise I wasn't using enough progesterone, extra stress! So I increased to 2tsp or 330mg/day, I suffered pain in every joint, muscles, was extremely tired and irritable. I persevered with this for 2 weeks, by which time my nails were strong again, and the pain had gone. And that's after using it daily for 15 years. Interesting you've been ill, progesterone does boost the immune system, but oestrogen causes oxidative stress, see here. It's another oestrogen dominance symptom, which shouldn't affect you again, specially as you're on such a good dose of vitamin D. This is an excellent paper on the damage oestrogen does, see here. If you have arthritis, please see here and
here. Take care Wray

Feb 21, 2011
Thanks for the links
by: Cindy here

Hi Wray I am devouring Ray Peat's website today thanks so much for the link . Checked out all the links , I love to read :)

Feb 22, 2011
Thanks for the links
by: Wray

Hi Cindy So pleased you're enjoying his writing, I find him excellent, very outspoken too! If you enjoy reading, you might like to look at Dr Cannell's website on vitamin D, another outspoken doctor, see The Vitamin D Council. I didn't give it to you before, strange, as I put it in all my comments, vitamin D is so vital to our health. There's another site you might to look at too called GrassrootsHealth. This site has many videos on vitamin D, all well worth watching. Take care Wray

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