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Perimenapause: do I take progesterone once I get my period?

by kara anneberg
(seattle, wa)

I have been diagnosed with estrogen dominance and 1 uterine fibroid the size of an orange. I am taking DIM and Vitalzym as well as your progesterone cream now. I had extreme flooding when my period would come. I am not bleeding now but when I start again, I want to know if I should continue to take progesterone during my period to make sure I don't have more flooding this time around.

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Nov 27, 2012
 Perimenapause: do I take progesterone once I get my period?
by: Wray

Hi Kara It would be advisable to use the progesterone daily, for at least 2-3 months. This should ensure progesterone becomes dominant and suppresses the excess oestrogen you have. Oestrogen is a mitogen causing cells to proliferate. So it not only causes the lining to build up, but it makes the fibroid grow too. I have found 400mg/day and over are needed to stop heavy bleeding. It's also necessary to take at least 2000mg/day NAC (N-acetyl cysteine), 2000mg/day taurine and 10,000iu's per day vitamin D. The NAC inhibits the MMPs which cause the lining to break down, there's more info on our page about Menstruation. Oestrogen stimulates the MMPs. Taurine is low in dysfunctional bleeding, see here. Vitamin D is vital, it prevents cells proliferating and is a potent anti-inflammatory. Sufficient vitamin D shrinks fibroids, see here, here, here and here. Please have a test done. For more info on vitamin D levels, test kits etc see the Vitamin D Council, GrassrootsHealth and Birmingham Hospital. Blood levels should be 70-100ng/ml (175-250nmol/L) and not the 30ng/ml (75nmol/L) most labs and doctors regard as adequate. The minimum daily dose should be 5000iu's per day, although recent research indicates it should be 10,000iu's per day, see here. The size of your fibroid is quite large, the nutrients might not be sufficient to shrink it, although they will probably stop it growing, certainly it will take many months to shrink. Unless it's controlled the heavy bleeding could continue. I think the fibroid started because you live in Seattle, you don't get enough sun there to make sufficient vitamin D for most of the year. So I hope by getting your D levels very high, round about 100mg/ml, it should start to shrink. This together with the progesterone to suppress the excess oestrogen, plus the NAC and taurine, might do the trick. I would hope so. Take care Wray
May 27, 2015
 Perimenopause
by: Anonymous

Hi Wray,

Just wondering if after the 2 to 3 months on a daily dose do I go back to the regular usage on days 12-26? My periods are not too irregular yet but I do have flooding.
Jan 04, 2024
 Wish someone would have answered this ..
by: Anonymous

Wondering this exact same thing!
Jan 04, 2024
 Wish someone would have answered this ..
by: Joy

The question has been answered ad nauseam on this website.  As mentioned by Wray, it would advisable to use progesterone every day with no breaks if one has adverse symptoms such as an unstable monthly cycle.  Once the cycle returns to normal, progesterone should be used during your luteal phase.  Please read the How to use Progesterone Cream page.  

Peri-Menopause is a difficult time.  The monthly cycle becomes erratic, with spotting/heavy bleeding/clotting.  It would then be advised to use progesterone every day with no breaks going forward.  

Take care.

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