Overly sensitive to progesterone cream?
I am a 40 yo mum of 4 who had always suffered from shocking pmt from ovulation through to period start. Symptoms included anxiety, anger, hyper, cravings (chocolate and carbs) depression and tearfulness and being overly sensitive, sore breasts, headaches and legs that wanted to run a marathon at night but the rest of me wanted to stay where I was, while I did get cramps they were not that bad.
I got full relief during each of my pregnancies or I was just so distracted with the 24 hr nausea and vomiting for the first 5/6 mths and then the very high Bp kicked in causing pre-eclampsia on first and then attending high risk clinics on other pregnancies and being put on meds and induced early because of this, my Bp remained high after my last one and I am on Bp tablets. I also haeomraged on every pregnancy no matter how much clotting agent I was given.
I could never really settle on the pill and rarely used it but had the more a fitted at 30 after my 4 th baby.
I still got monthly cycle but very light and was fine and most of my symptoms eased dramatically.
It was removed and not replaced when I was 35 and my cycle never regulated. My health issues increased, started suffering tonsillitis regularly, pmt came back with a vengeance, missed periods, heavy periods for 2-3 wks, got glandular fever, quinsy, back surgery, flus panic attacks for the first time ever,etc...these issues were endless. History of early meno in family so asked doc to do tests and he eventually gave in. Blood tests showed: FSH 50 u/l Oestradiol 110 pmol/L and progesterone 2 nmol/l
Was put on the pill as I was told I needed a higher dose due to my age being in peri meno. Within 5 days I was an anxious mess and Bp through the roof so binned the tablets and saw a bio identical doc. Meanwhile I started indolplex, AMAZING relief and take 4 capsules a day. The total and utter fatigue lifted enough to allow to me get through a day, the anger/rage eased along with other pmt symptoms, not perfect but was grateful for the relief.
Saliva test showed these results:
E1 was 11. E2 was 2. E3 was 41 progesterone 576 testosterone 258
I was given 4% progesterone cream in a Mac base 50 ml and told to take .5 ml at night.
I did this and was feeling great but I was not using nearly the amount, I got breakthrough every mth on day 7 and had to stop. I realised without the syringe which I lost, I was not using the prescribed amount. And got a new one but since then I have become very moody and irritable, exhausted,depressed, zero libido, etc almost a full return to the old ways and am finding it really difficult when I had been doing so well and I have only just increased the dose to its correct amount in the last week. I also started using MACA capsules, to aid the indolplex in reducing the bad estrogen but appetite increased as did cravings so I have cut back to one capsule every other day for the moment. I take citracal with vit d supplement (vit d has flagged low occasionally) I use fish oil and also probiotics daily. One thing I have noticed since I increased the cream is that I am going to the bathroom almost daily when I have spent my WHOLE life (since age 2) battling constipation/piles/ thrombosed hemeroids which is really the ONLY benefit since increasing to the correct dosage. Having read through almost all of this, despite the symptoms, I wonder am I using enough or too much given the above info. Apologies for this massive history but I figured it is more helpful to have all details than not enough! I hope my info helps people and that I can also gain some knowledge, this is an incredibly informative site!