Men and progesterone

by Terri Oetinger
(Okeechobee, Fl)

I would like to know if a man in his 50's could benefit from using progesterone cream and if so how much should he use? Thank you.

Comments for Men and progesterone

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Dec 18, 2007
Men and progesterone
by: Wray

Hi Terri Yes men can benefit from progesterone. The dose ranges from 20mg/day to 200mg/day. It's critical to the production of sperm, influences spermiogenesis, sperm capacitation/acrosome reaction and testosterone biosynthesis. Progesterone inhibits 5-alpha reductase, the enzyme which converts testosterone to dihydrotestosterone, a safer alternative to the drug finisteride.

Gynecol Obstet Invest. 1993;36(4):234-8.
Progesterone reduces sympathetic tone without changing blood pressure or fluid balance in men.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=8300009&dopt=Citation

Fertil Steril. 1999 Nov;72(5):817-22.
Serum ionized magnesium and calcium and sex hormones in healthy young men: importance of serum progesterone level.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=10560984&dopt=Citation

The Aging Male , Volume 7, Issue 3September 2004 , pages 236 - 257
Progesterone: the forgotten hormone in men?
http://www.informaworld.com/smpp/content~content=a713634215~db=all

International Urology and Nephrology
Issue Volume 24, Number 2 / March, 1992
In vitro study of rat prostate 5alpha-reductase activity and its inhibition
http://www.springerlink.com/content/b10r924361538473/

A Comprehensive Look at Hormones and the Effects of Hormone Replacement
Pamela Smith, M.D., MPH
Director of the Fellowship in Anti-Aging and Functional Medicine
Original in pdf, no web address available.
Paste the following into Google and the full paper will appear at the top of the page:
A Comprehensive Look at Hormones and the Effects of Hormone Replacement






Nov 13, 2009
Convert units to fluid measure please
by: Max

Could you convert the amount of cream in a tube from grams to ml and/or the oz weight to fluid ounces (US) please? I don't have an analytical balance to measure out the dosage. I do however have common cooking measuring implements. Thanks.

Jan 15, 2010
Convert units to fluid measure please
by: Wray

Hi Max. The specific gravity of the cream is 0.94, almost the same as water, so we regard 1g to be the same as 1ml. Cooking measuring implements are the easiest to use, certainly initially until you become used to the amount, 1tsp equals 5ml. The amount of cream to use is not critical, what is important are the symptoms. The more severe, the more cream is needed. Hope this helps. Take care, Wray

Dec 21, 2011
MEN-Soy? natpro has Soy product?
by: Anonymous

Wray (or anybody), Im confused, you say in another place on the blog responding to "man Boobs" as other causes..." Foods containing phytosterols, particularly soy, have oestrogenic affects. Soy reduces the sperm count in men, avoid eating it!". Yet one of the ingredients in Natpro is soy? Please advise the difference. Thank You

Jan 20, 2013
Progesterone has lowered my estrogen levels
by: David G. Mills

When I was first found to have low testosterone, my estradiol levels were also checked. The testosterone number was 155 (200 is the low limit of normal) and the estradiol number was 46 (high limit of normal is 50).

After being on both Androgel and bio-identical progesterone for about 1 year I had both levels checked again. My estradiol level was 28 (normal midrange) and my testosterone level was 228 (low normal range.

The ratios of the testosterone number to the estradiol number went from 3.36 to 8.14.

When I was on testosterone shots before I took bio-identical progesterone, my testosterone was 1176(too high as high normal is 700) and my estradiol level was 82. I was having bad estrogen symptoms at the time including gynocomastia and shrunken scrodal sac. Also had about 10 % weight gain either from the testosterone or estradiol or both.

Testosteone shots have worked far better than Androgel at boosting testosterone but I recently had an testosterone test on Androgel where I had testosterone levels of 413. Still experimenting with different testosterone dosages and types, because I have been highly erratic. Right now, with a new doctor I am not taking any to see what my baseline is after two years of testosterone replacement therapy.

Overall, progesterone has really done a good job in reducing estrogen symptoms, but so far has not had much effect on my enlarged prostate. Doctor finally had to put me on Finasteride. My PSA levels have always been low and remain so at about .8 (normal range of 0-4). My weight is back to where it was before I started testosterone therapy.

Jan 24, 2013
Progesterone has lowered my estrogen levels
by: Wray

Hi David Thanks for the feedback, always appreciated. Your lab has slightly different ranges for the hormones than Medline. Their testosterone ranges from 300 to 1200 ng/dL, and their oestradiol range is 10 - 50 pg/ml. Keratin have similar ranges. I've looked through the other page you posted on and find you were/are using about 34mg/day progesterone. I don't feel this is sufficient. I would ask you to try a higher amount, as I'm concerned about the Finasteride, see here, here, here and here. It can cause depression and low Libido. There is so much evidence progesterone does help the prostate, not to mention anecdotal info from men using it. This is a recent paper here. It's safety is without question, over 1200mg/day being given via IV transfusion to Traumatic Brain Injury victims, over 70% are men too. A very recent study, on which I did a page here, used far higher levels, with no signs of toxicity at all. Continued below

Jan 24, 2013
Progesterone has lowered my estrogen levels Part 2
by: Wray

Hi David And have you had a recent vitamin D test done? I know your level was very low, and you were taking 5000iu per day, but this is more a maintenance dose. Higher doses are needed to bring the level up. It's so important for the prostate, including cancer, see here, here, here, here, here and here. Take care Wray



Sep 19, 2013
progesterone cream and orchiectomy
by: Anonymous

Hi Wray,

My husband has had orchiectomy but is now hormone refractory. He is on Nizoral and Prednisone. Can progesterone cream benefit him?

Sep 22, 2013
progesterone cream and orchiectomy
by: Wray

Hi there I'm assuming he had the orchidectomy because of cancer? And also assuming it's spreading as he's not responding to the drugs? Progesterone has been used successfully against Cancer. The latest study came out at the end of 2011, in which they used very large amounts, see here. I would suspect your husband is very low in vitamin D, please have a test done. A low level increases the risk of over 20 different cancers. These are excellent videos to watch on vitamin D and cancer, see here, here and here. Cancer feeds off sugars. I suggest he tries the Ketogenic Diet, see here. It reduces glucose levels to the barest minimum, and the body uses ketones for energy. It's a very high fat, moderate to low protein and very low carb diet. Only the good fats should be used, i.e. MCT oil, coconut oil, butter, olive oil or macadamia oil. The first three are saturated fats, the other two mono-unsaturated fats. The best is the MCT oil, an extract from coconut oil. The body converts the fatty acid into ketones, in fact the brain does better on these than glucose. MCT oil forms ketones more efficiently than the other oils. The diet varies from a 4:1 ratio of fat to protein/carb down to a 1:1 ratio. This Ketogenic Diet Meal Planner might be of help. Take care Wray

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