Low Progesterone and Insulin Resistant

by Andrea
(San Francisco)

I have been having the worst periods along with emotional ups and downs ie. frustration, anxiety, anger and insomnia. I recently went to a specialist who infmormed me that I had a hormone imbalance and Insulin Resistance.

What was prescribed that day was to remain on the contraceptive pill and Glucophage. No explanation of why to remain on pill. From the lack of infomation given to me I sought a second opinion. Second Dr. told me that I had extremely low progesterone and yes, I was Insulin Resistant. I stopped the pill under her advice and I have been prescribed Bio-Identical Progesterone and will begin in 5 days. My question is how do I manage the IR? Can I take the Progesterone and Glucophage? Also, with extreme low progesterone what are my chances of conceiving?

Very informative sight, love it! Thank you.

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Jan 30, 2010
Low Progesterone and Insulin Resistant
by: Wray

Hi Andrea. Thanks for the kind words! The contraceptive pill can cause IR, not what you want, please see this web page. Glucophage is a diabetic drug, which also reduces B12 levels, not what you want either. Please see here. And here.

It's far safer to treat IR naturally. As so many have it, including me, I have done a web page on it, you might like to read it here.

I do hope the progesterone you've been given is not oral, it's not the best delivery system, most gets destroyed in the gut and liver. The best systems are injections, suppositories and creams. Please try to use between 100-200mg/day. By using a good dose of progesterone and reversing the IR, there is every chance of conceiving. You might like to look at this web page on pregnancy.

Although you don't mention PCO, patients with this are often given glucophage, progesterone levels are low, plus IR is almost always present, so you might like to look at the PCO page too. It also gives info on diet etc.

Please have a vitamin D test done, this is often low in IR, in fact some authorities believe a deficiency is an exacerbating factor, if not the cause, see here. You might consider taking argnine and cysteine too, both powerful antioxidants which reverse ovarian malfunction, please see here. Although it's referring to PCO, oxidative stress is behind many, if not all our problems. Taurine is another vital amino acid to take, up to 5000mg/day, it helps stabilise blood sugar and more! Take care, Wray

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