I am 53. Had a hysterectomy about 6 or 7 years ago because of heavy periods. Began Bioidentical hormones about a year later. Never felt that awesome on them, but believed it would help. Sore nipples off and on, achy joints especially hips, difficult to lose weight and keep it off. A little over a year ago I was occupied with a family member who was ill. I found myself not using my estrogen, progesterone, or testosterone on a regular basis. My weight dropped without any changes, my joints didn't hurt, no tender breasts, no moodiness. Not thinking my bioidenticals played a role, I just thought my body was changing. I went for my yearly 24 urine test and these were the results: Estrone 1.5, Estradiol 0.6, Estriol 1.6. Pregnanediol (progestrone metabolite) 78. DHEA 17. Testosterone 2.1. Cortisol 74, HGH 447, melatonin 6.9. My Natorpath changed my estrogen cream just a little. For the past 3 months I have been using Tri-est 1.375 MG/GM versabase. 1GM daily. Testosterone 0.2% 1GM daily. Progesterone 4% 1Gm daily. In the last month I have felt that I was developing love handles. The scale was not going up, but still felt like I was gaining weight. Hips sore, no sex drive, dry vagina, couldn't sleep, getting grumpy, headaches. Thought it was because my estrogen was low. Kept putting on my bioidentical creams daily. About eight days ago, I woke up 4 lbs heavier, extremely sore nipples/breasts, bloated, agitated, unable to get good nights sleep. Does it always happen so fast?. Started searching on internet about my symptoms and found your site. Stopped taking estrogen and testosterone immediately. Upped my progesterone to 80mg twice a day. Felt worse. Ordered your progesterone (3 tubes) and energy boost. While waiting for my order, I am increasing the dose of the bioidentical progesterone I have on hand. Today I used 200mg in the morning and 200 mg in the evening. Sleeping much better. Still extremely sore breasts, gaining weight, bloated and moody. What is your advice? Do you agree I have estrogen dominance? Will It take a long time to get back (or better) to where I was? Thank you for any help you can give me. I look forward to hearing from you.