I am scared to use Progerterone therapy

by Scared in Oregon

I have been diagnosed with endometrial hyperplasia. The recommended treatment is medroxyprogesterone generic for provera.
I am post menopausal for 6 years. I do not want my period to come back, I don't have excessive bleeding, I had some spotting and a clear dishcarge... not itching or anything.

I have had 3 biopsies.They want me to take progerterone for 3 months (21 days on then get period 5 days later start again). I had a pulmonary embalism at a young age so I have never been on any type of hormones... i.c. birthcontrol or anything.

I am afraid of the side effects, I have told my concerns to my Dr. and she says this is the best therapy and hysterectomy is too invasive and dangerous. Is this an insurance thing?

Comments for I am scared to use Progerterone therapy

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May 05, 2009
I am scared to use Progerterone therapy
by: Wray

I entirely agree with you about being scared taking MPA, it is not progesterone!

To my mind the side affects are not worth the risks. Please look at this web page which shows the difference between a progestin molecule and a progesterone molecule, you'll see they are very different:


We also have another web page with research papers showing the adverse effects progestins have, please have a look at it:


Progesterone on the other hand will benefit you and has no known adverse side affects. It's vital for pregnancy, so if there were adverse side effects, all pregnant women would be very ill. It does not increase the risk of clots, the reverse in fact, as it prevents platelets aggregating. I do agree with your doctor about hysterectomy being invasive and dangerous. Take care, Wray.

Jun 19, 2010
post menopausal endometrial hyperplasia
by: Christina

Last week I too was told by my gynecologist that I likely had endometrial hyperplasia and like Scared in Oregon I am post menopausal. The last time I had a period was 10 years ago. When I saw the doctor for my appointment last week it was for the removal of a vaginal polyp. At that time, he informed me that the lining of my uterus was over 5 cm and he wanted me to have a biopsy done as well as the removal of the polyp. I wasn't prepared to do the biopsy right then so I declined. After the polyp was removed I experienced a great deal of cramping and discomfort for a couple of days and then I started spotting. I am not sure if the spotting is from the removal of the polyp or my uterus. The doctor did not explain what I should expect after the procedure. I am worried about what the spotting might mean. I have read Wray's website on Progesterone therapy and I am wondering if I should start using Natpro cream and what the recommended dosage is. I don't want to go on HRT or use the estrogen cream suggested by my gynecologist. Nor do I want to have a hysterectomy. Any thoughts or advice?

Jun 22, 2010
post menopausal endometrial hyperplasia
by: Wray

Hi Christina I'm stunned your gynae suggested HRT or an oestrogen cream. Oestrogen and only oestrogen can cause cells to divide and multiply. This is the only reason the lining of our uterus builds up each month. Even after menopause we are still making oestrogen, as our fat cells are a source. No matter how many or few we have! I'm relieved you don't want to use the HRT, but you might like to read more about what it can do to us, on our web page HRT Research. Every month our uterine lining builds up, and just prior to our periods, progesterone levels drop sharply. This enables MMP's, enzymes that break down protein, to break down the lining. But once in menopause, particularly 10 years into it, the messages sent between the uterus, hypothalamus, pituitary and then back to the uterus stop. So slowly your lining has built up, although normally it gets absorbed back into the body over time, it appears yours hasn't. Progesterone will suppress the oestrogen that's causing the lining to grow, and most probably you will have a bleed, possibly two. But it's just the old blood coming away, I can assure you won't start menstruating again! Please see these two papers on endo hyperplasia here, and here. I generally recommend between 100-200mg/day, you will have to experiment with the amount, as I don't know what other symptoms you might have. ie you might be fine on the lower amount, or use the higher amount initially, reducing when you feel stable. As for the hyst, you might like to see this site on Hysterectomy Take care Wray

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