Hyperplasia

by Cathy
(Canada)

3 years ago I was diagnosed with simple and complex hyperplasia without atypia. Dr. put me on Provera which I suffered through for 18 months until I quit cold turkey. Went to a naturopath who had me on supplements and things were not too bad until this past April when I started on a two month period of heavy bleeding and clots and ended up extremely anaemic.

Had an ultrasound while still bleeding and showed thickness of 1.4cm. Went to an integrative MD who put me on 75mg progesterone cream twice daily and bleeding stopped within 48 hours. Have since had one period which was heavy but without clots and lasted a more manageable six days. Had an ultrasound last week and lining in now 6mm but gynecologist still recommends hysteroscopy and D&C.This has me really nervous.

Is it necessary? Does the fact that the cream stopped the bleeding indicate a benign process of hormone imbalance which can be corrected with continued use of progesterone? Any thoughts to put my mind at ease would be most appreciated. Thanks.

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Hyperplasia

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Aug 04, 2011
Hyperplasia
by: Wray

Hi Cathy Your integrative MD knows what he's doing, stick with him and not the Obgyn! Oestrogen is a mitogen, it stimulates cells to grow. Vital in stimulating the endometrium each month to grow and thicken ready for a possible fertilised egg. But in excess it stimulates cells to continue growing. MMP?s are enzymes that break down protein. They play a role in the breakdown of endometrial tissues at the end of the menstrual cycle. If they are over active, as would be the case with excess oestrogen in the body, as oestrogen stimulates their production, the result is a pathological reaction. A high level of MMP's can lead to inflammation and excessive bleeding in the uterus. If a low level of progesterone is present, and a high level of oestrogen, the lining will continue to grow. With a high level of MMP's the lining will also continue to break down. Progesterone suppresses both MMP's and oestrogen. The amount you were given was good, although I generally recommended 400mg/day and over, especially if the bleeding is heavy and continual. I'm taking a guess you are now in Peri-menopause when our cycles become erratic, varying from very light to flooding, often with clots. This is normal and certainly doesn't warrant a hyst! For more info see this excellent website here. Please have a vitamin D test done, you live in Canada where levels are often very low, see here, here, here and here. It's essential for the normal functioning of our reproductive system, and much more. Please see the Vitamin D Council, GrassrootsHealth and Birmingham Hospital websites for more info. Take care Wray

Aug 05, 2011
Hyperplasia
by: Cathy

Faye, thank you so very much for taking the time to respond. Yes, I am perimenopause at 51 years of age. I have been under a terrible amount of chronic stress for years. My husband has MS, my daughter has a thyroid nodule (which I'm desperate to avoid surgery for-any ideas?) and my 80 year old mother has suffered from severe depression for the past three years. The last thing I needed is for my own health to decline. Since I first posted, I started to have a brown discharge 3 days after the gyn's ultrasound which showed the 6 mm lining. It lasted a couple of days then turned into a full bleed which is still ongoing 9 days later. Would you expect this on progesterone? Should I ask for an increased dose? Sorry for all the questions but I'm just about at the end of my rope with everything that's going on around me. Thanks!

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