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Hormone Levels

by Lenier
(Kansas City, MO)

I'm a 38 male and have been having some issues with energy and low libido, I'm not over weight and exercise 3 to 5 days a week, after a few month of dealing with i decided to get a saliva hormone test done, i got the results yesterday and review with my doctor but i don't think my doctor is very knowledgeable with hormones, below are the results from my test and the answer i got from the lab and my doctor, i did order some of your cream but don't know if i should use it since the progesterone is high, if you can provide some advice on this will be great.

Progesterone 174 pg/ml high
DHEA 8 pg/ml normal
Androstenedione 242 pg/ml normal
Testosterone 117 pg/ml high
DHT 75 pg/ml high
Estrone 67 pg/ml high
Estradiol 15 pg/ml high

I'm still having some of my issues low libido, energy is not an issue anymore.

Comments for Hormone Levels

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Jan 16, 2013
 Hormone Levels
by: Wray

Hi Lenier Your levels are high, except for the testosterone, which according to ZRT labs is within normal range, male all ages 44-148 pg/ml, or male ages 31–50 58-120 pg/ml, see ZRT Laboratory Saliva Reference Ranges. Your progesterone is high, normal range is 15–100pg/ml, but it goes much higher if supplementing, so it's of no concern as it's so beneficial. But what concerns me are your oestrogens, normal range for oestrone is 2–10pg/ml and for oestradiol 0.8–2.2pg/ml. This would account for the lowered Libido. It would also affect energy levels. It's an excitatory, inflammatory hormone, and causes cells to proliferate. So I'm amazed you haven't put on weight or are retaining water. Possibly the high progesterone is helping here, as its an excellent diuretic, it also inhibits mitosis, levels of over 1200mmg/day are given for Traumatic Brain Injury, over 70% of the victims are men. Why your oestrogen is high puzzles me. There are two possible reasons, one is your aromatase is too high or you are eating or drinking a great deal of phytoestrogens in your diet. Aromatase is an enzyme which converts testosterone into oestrogen. This same enzyme is found in women too, where it plays the same role. But why should your aromatase be high. Are you taking any growth hormones, or do you drink or eat milk products made from cows given BGH (bovine growth hormone)? BGH increases levels of IGF-1, which in turn increases aromatase levels, see here, here and here. This is an interesting paper here on the excitability of oestrogen. By using an aromatase inhibitor, oestrogen levels were reduced and seizures stopped. Although I disagree with their remark that due to low testosterone levels the man had sexual dysfunction, I feel it was due to lowering oestrogen levels that his libido came back. Continued below
Jan 16, 2013
 Hormone Levels Part 2
by: Wray

Hi Lenier Many hypersexual men have low testosterone....."....although a critical level of androgen is functionally available at receptor sites, there appears to be little correlation between plasma testosterone levels and sexual behavior. Both impotent men and hypersexuals may have concentrations within normal range (Schiavi and White, 1976) and considerably elevated endogenous testosterone concentrations in a small group of impotent males (Cooper et al., 1972). Thus, it may turn out that the significance of testosterone in determining libido and potency has been overstated. According to Cooper (Cooper, 1986), as long as a "physiological" minimum is available, the hormone may merely be one of a number of interdependent neurotransmitters, which modulate sexual and reproductive functions. The importance of testosterone for central sexual function such as libido or whether it also has an effect on the end orgasm tissues in the penis is still debated.", see here. Unfortunately only the full paper, which I bought, has the above passage. Low zinc and high insulin also have a tendency to increase aromatase. Are you stressed, as cortisol also induces aromatase expression, see here. You'll notice that progesterone inhibits aromatase secretion. This paper here has more info. It appears dopamine is the main player in a good libido, progesterone too. We have many men using it to raise theirs. High oestrogen stimulates Prolactin, high prolactin depresses dopamine, so libido drops. The other reason I gave was high phytoestrogens in your diet. Do you drink much soy milk, or eat many legumes? These all have a high phytoestrogen content, which can raise oestrogen levels, see here and here. This last paper is interesting as his oestrogen level was 4 times higher than it should be. Yours is even higher. So I suggest you use at least 100mg/day progesterone, I tend to advise far higher levels than the norm, as I've found too low a level merely stimulates oestrogen, not what you need. Please watch for Oestrogen Dominance, it affects both men and women alike. I've found the higher the oestrogen level the more likely symptoms occur if insufficient progesterone is used to suppress it. Take care Wray
Jan 18, 2013
 Hormone Levels
by: Lenier

Hi Wray thank you for the information to give more information I follow a paleo diet for 80% of my food I do drink coffee in the morning with some organic cream and also i smoke about a pack a day, I have been having a hard time keeping my current weight, so i think the high estrogen is the issue, i started using the cream but having a hard time figuring out how much is 100mg, would you provide more information of how measure the cream to get the right dosage.
Jan 19, 2013
 Hormone Levels
by: wray

Hi Lenier Well that leaves me baffled! I also follow the Paleo diet most of the time, plus have cream in my coffee. So that eliminates the phytoestrogen link. Please could you increase your zinc, which could be low. Try taking 100mg/day, a high dose, for about 2 weeks, a month would be fine too, then reduce to about 15mg/day. Oestrogen raises copper levels, decreases zinc, progesterone does the reverse. So it could be that low zinc is increasing aromatase, which in turn is increasing oestrogen, which depresses zinc etc! Let me know if this helps you. Do you have any kitchen measuring spoons? These often come in millilitre measurements, alternatively a spoon from a health shop which usually has graded amounts. 1ml contains 33.3mg, so you would need 3ml. This is just over 1/2tsp, provided the teaspoon is a 5ml spoon! We do have a chart at the bottom of our page on How to use progesterone cream. Let me know how you get on. Take care Wray
Jun 20, 2013
 WRAY
by: Anonymous

WRAY ,
I dont know you , I think you are completely wrong on most things that you are talking about. Low libido and ability to achieve orgasm is what this guys has, and that is from high progesterone, since progesterone inhibits DHT. Also he has sugar problems which cause energy lows. It is really funny how you recommend this progesterone))))
Jun 23, 2013
 WRAY
by: Wray

Hi there You say I'm wrong about most things. Well all my info comes from studies, done since the 1930's, so they too must all be wrong! Yes he does say he has low Libido, but nowhere does he mention orgasm. And I don't see why it's funny I should recommend progesterone, yes his levels are high, but so is his oestrogen. Evidently his testosterone is being converted to oestrogen by the enzyme aromatase, progesterone is an aromatase inhibitor. I've explained about the possible reasons for high aromatase. Take care Wray
Jun 23, 2013
 WRAY
by: Anonymous

This guy has perfectly normal aromatase rate. His estrogen and progesterone are high ..But progesterone is little higher on the scale, which makes sodium lower in the cell than potassium on the relative basis. You suggesting more progesterone will turn off his immune system. This guy is obviously stressed , unless he is taking some adrenal hormones like pregnenelone. This guy need manganesium and copper.

Good luck

I am not trying to be rude/just saying
Jun 25, 2013
 WRAY
by: Wray

Hi there Thanks for your comments, they do make me think. Although now I don't understand why you say his aromatase is normal, he didn't have a test done. And why then is his oestrogen so high. Funnily enough progesterone doesn't turn off his immune system, if anything it boosts it primarily because it's an anti-inflammatory and antioxidant. It does inhibit it in the uterus when a woman is pregnant, i.e. it prevents rejection of the embryo. He could well be taking something I'm unaware of. This is the problem when trying to help people via the web, there's no knowing what else could be affecting them. Copper would certainly reduce his progesterone, but it would also increase his oestrogen, not what he really wants. Take care Wray

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