Hiv protease inhibitors(kaletra) and progesterone

by Dario
(Bogota Colombia)

Hi everybody:

I´m a 34 years old man, i´ve been four years medicated with kaletra (lopinavir/ritonavir), ´cuase i´m hiv positive. Since then, i began to suffer erectile dysfunction and loss of libido. Medics, infectologist, endochrinologist, urologist, only told me that´s anxiety caused by living with hiv, or same virus, they really don´t know the reason ´cause medications have these side effects, all of them misterously told me 'Take viagra'...... I went to psychologist and psychiatrist........and all is ok. Recently i´ve been very, very frustrated with this issue, so i began a small research (i have huge biology knowledge).There´s no much research but i found this recent where is proven that HAART affects progesterone synthesis

and this

and others

If it´s done to women with higher progesterone levels...... men are f*****. I´ve read that nearly and more than 38% of men with my medication suffer ED and low libido, kaletra also can cause osteoporosis (one of low progesterone symptoms)

So i found this website, i´ve read about progesterone cream and bought it, so i wanna now how could i dose it? i began on sunday and........ well i slept like a baby, i´m feeling better than ever on this four years, but still no libido, i´m tryng with nearly 1/8 of teaspoon. What do you advice me? How long could take to see any effect on libido?


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Sep 12, 2014
Hiv protease inhibitors(kaletra) and progesterone
by: Wray

Hi Dario Thanks for the papers, I'd not seen them before, very interesting, alarming too. Pregnant or not it would affect progesterone levels in both men and women. I see kaletra can cause a number of other adverse reactions, including a change in "heart rhythm and the electrical activity". I find this interesting as progesterone calms the heart, while oestrogen causes prolongation of the QT interval, which results in palpitations, arrhythmia, Torsades de Pointes and sudden death. Progesterone shortens the QT interval, see here, here, here, here, here, here, here, here, here and here. These symptoms occur far more frequently in women who naturally have a long QT interval, rather than men who naturally have a short QT interval. I'm delighted you're responded to progesterone so quickly, it can take 3-6 months before any lasting effect is felt. When you ask for dosing, I'm not sure what cream you are using. We never say use 1/8 teaspoon, but always quote in milligrams or millilitres, so I have no idea how much progesterone you're using. But I would suggest starting on 100mg/day, this is 3ml of our cream. Continued below

Sep 12, 2014
Hiv protease inhibitors(kaletra) and progesterone Part 2
by: Wray

Hi Dario You ask an impossible question…."how long see any effect on libido"? We are all so different I don't know. You've already responded quickly to the progesterone, so hopefully your Libido will come back quickly too. Have a look through this page, dopamine is also essential for a good libido. Please look through these papers here, here, here, here, here, here, here, here, here, here, here and here on Vitamin D. For further updates please see PubMed. It seems most people with HIV have low levels. Is this a cause of AIDS or the result of the drugs? One wonders. Please have a test done. Take care Wray

Sep 12, 2014
by: Dario

Thanks for the info, very interesting articles.......I was reading in one of the articles that ritonavir(one of kaletra´s component) and efavirenaz have high incidence on lowering vitamin D levels :\.

Yesterday is later to buy some D3 supplement, more important than progesterone. Is strange i play martial arts, i´m healthy, don´t smoke, i have a good nutrition, so is strange present this issues, sadly in my country health is a disaster, fortunately hiv porgrams are 'decent' comparing other health fields, i´m thankfull to have my medication at time.

Again thanks for all helpfull info in this website. Interesting all good articles from recognized magazines.

Thanks again

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