Factor V

I have Factor V leiden disorder. Having thick lining and am post menopausal. Dr. put me on Prometrium 12 days of each month. Is this safe with having Factor V?

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Factor V

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Nov 20, 2007
 Factor V Leiden disorder
by: Wray

Hi there Yes Prometrium is safe, it's a natural progesterone. But are you taking the oral version or suppositories? 90% of oral progesterone is destroyed by the gut and liver as it passes through, so is not very effective. The cream, suppository or injection route is much more effective. I have pasted some comments from research papers for you.

"The studies reviewed suggest bioidentical progesterone does not have a negative effect on blood lipids or vasculature as do many synthetic progestins, and may carry less risk with respect to breast cancer incidence. Studies of both bioidentical estrogens and progesterone suggest a reduced risk of blood clots compared to non-bioidentical preparations. Bioidentical hormone preparations have demonstrated effectiveness in addressing menopausal symptoms."
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=17217322&dopt=Citation

"Progesterone inhibited cholesterol into cholesteryl ester (CE) and decreased CE cellular levels."
http://jcem.endojournals.org/cgi/content/abstract/84/1/265

"Coronary hyperreactivity, a putative component of coronary artery disease mediated via increased vascular muscle thromboxane prostanoid receptors, can be prevented by subphysiological levels of P, not only in nonatherosclerotic (previously shown) but also in preatherosclerotic primates."
http://atvb.ahajournals.org/cgi/content/abstract/24/5/955

Hope this helps Take care Wray
Oct 10, 2010
 Factor V Leiden and Progesterone
by: Lisa

Wow this is what I have and my doctor suggested I take some progesterone too! I didn't think I would find any answers.
Oct 14, 2010
 Factor V Leiden and Progesterone
by: Wray

Hi Lisa Yes we have many asking about it, just another last week in fact. I'm pleased your doctor recommended progesterone. In FVL, factor V remains active, which allows over production of thrombin, leading to excess clotting. Oestrogen in any form is contraindicated as it increases the affect of thrombin, progesterone on the other hand decreases it by 10-15%, please see here. It also protects against lipid peroxidation and atherosclerosis, please see here and here. Please avoid all contraceptives as they increase the risk of clots, see here and here. The only safe contraceptive is the copper T IUD, it doesn't leak a drug into the body, see here. If you should consider using progesterone, please read this page on How to use progesterone. You might like to see the other delivery systems available, please see our page on Progesterone application methods.
Take care Wray

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