Factor V

I have Factor V leiden disorder. Having thick lining and am post menopausal. Dr. put me on Prometrium 12 days of each month. Is this safe with having Factor V?

Comments for
Factor V

Click here to add your own comments

Factor V Leiden disorder
by: Wray

Hi there Yes Prometrium is safe, it's a natural progesterone. But are you taking the oral version or suppositories? 90% of oral progesterone is destroyed by the gut and liver as it passes through, so is not very effective. The cream, suppository or injection route is much more effective. I have pasted some comments from research papers for you.

"The studies reviewed suggest bioidentical progesterone does not have a negative effect on blood lipids or vasculature as do many synthetic progestins, and may carry less risk with respect to breast cancer incidence. Studies of both bioidentical estrogens and progesterone suggest a reduced risk of blood clots compared to non-bioidentical preparations. Bioidentical hormone preparations have demonstrated effectiveness in addressing menopausal symptoms."
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=17217322&dopt=Citation

"Progesterone inhibited cholesterol into cholesteryl ester (CE) and decreased CE cellular levels."
http://jcem.endojournals.org/cgi/content/abstract/84/1/265

"Coronary hyperreactivity, a putative component of coronary artery disease mediated via increased vascular muscle thromboxane prostanoid receptors, can be prevented by subphysiological levels of P, not only in nonatherosclerotic (previously shown) but also in preatherosclerotic primates."
http://atvb.ahajournals.org/cgi/content/abstract/24/5/955

Hope this helps Take care Wray

X Close Editor

Rating

Submitted by: Wray

Title

Comment
Hi there Yes Prometrium is safe, it's a natural progesterone. But are you taking the oral version or suppositories? 90% of oral progesterone is destroyed by the gut and liver as it passes through, so is not very effective. The cream, suppository or injection route is much more effective. I have pasted some comments from research papers for you. "The studies reviewed suggest bioidentical progesterone does not have a negative effect on blood lipids or vasculature as do many synthetic progestins, and may carry less risk with respect to breast cancer incidence. Studies of both bioidentical estrogens and progesterone suggest a reduced risk of blood clots compared to non-bioidentical preparations. Bioidentical hormone preparations have demonstrated effectiveness in addressing menopausal symptoms." http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=17217322&dopt=Citation "Progesterone inhibited cholesterol into cholesteryl ester (CE) and decreased CE cellular levels." http://jcem.endojournals.org/cgi/content/abstract/84/1/265 "Coronary hyperreactivity, a putative component of coronary artery disease mediated via increased vascular muscle thromboxane prostanoid receptors, can be prevented by subphysiological levels of P, not only in nonatherosclerotic (previously shown) but also in preatherosclerotic primates." http://atvb.ahajournals.org/cgi/content/abstract/24/5/955 Hope this helps Take care Wray

Cancel Delete Delete & Ban

throbber Updating Comments page...