Estrogen Dominant

by April Smith
(Sacramento, CA, USA)

I am 49. I don't have a complete story yet. I haven't tried the Progesterone Cream yet. I have ordered it. I just learned after an ultrasound that I have a thick endometrial lining which I will need a DNC for.

My question is my day 14 after the period is day after tomorrow and I ordered the cream a week ago. If I do not receive it tomorrow in the mail, can I apply it as soon as it gets here. I am anxious to get the help. My usual cycle is 28 days.

Although the reason I went to get my hormones checked is because I suddenly had a period that last over 3 weeks and it was quite painful. The doctor put me on Progestine which stopped the period and then ordered an ultrasound.

I'd appreciate some advice. Thank you.

Comments for Estrogen Dominant

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May 09, 2011
Estrogen Dominant
by: Wray

Hi April At 49 you are now in Peri-menopause, it's not unusual to have a thick endometrium. I see no reason for a D&C. Our cycles become very erratic in P-M, sometimes two weeks apart, sometimes 3 months. Sometimes they are very light, sometimes flooding with clots and cramping. All this is normal, although unpleasant. Oestrogen is a mitogen, it stimulates cells to grow. Vital in stimulating the endometrium each month to grow and thicken ready for a possible fertilised egg. But in excess it stimulates cells to continue growing. MMP?s are enzymes that break down protein. They play a role in the breakdown of endometrial tissues at the end of the menstrual cycle. If they are over active, as would be the case with excess oestrogen in the body, as oestrogen stimulates their production, the result is a pathological reaction. A high level of MMP's can lead to inflammation and excessive bleeding in the uterus. If a low level of progesterone is present, and a high level of oestrogen, the lining will continue to grow. With a high level of MMP's the lining will also continue to break down. Progesterone suppresses both MMP's and oestrogen. It is essential to use a high amount of progesterone, between 400-600mg/day. If the bleeding is continual, use it both daily and hourly. Using it hourly keeps the level high throughout the day. If there is a cycle, it?s best to ignore it and use the progesterone daily, hourly too, until the bleeding is under control. Then slowly reduce the amount used until the optimum is found. The progesterone can be used to regulate the cycle once bleeding has stopped. See here and here. Progesterone levels drop during P-M, but oestrogen doesn't until Menopause is reached. I think my reply will come too late, I now have so many queries, I can't answer them in time. But yes you can start using progesterone after ovulation. But please read our page on Oestrogen Dominance if you haven't already done so. It can occur and is disconcerting if it does. Take care Wray


May 23, 2011
Estrogen Dominant Reply
by: April Smith

Hello Wray, It is very interesting that you are saying I do not need to get the D&C. I have been waiting to get a payment plan call back for a $4000 procedure. The doc wants to see why I am estrogen dominant and remove the thick endometrial wall. She could have done an in office biopsy procedure. I chose the D&C to make sure more was not wrong and to have relief from the heavy periods. Now reading from you I am wondering if this D&C is no necessary. Wow, I'm actually shocked after having had this recommended.
Perhaps I could start the Progesterone Cream for a couple months and go back and see if the Estrogen has gone down. The ultrasound found the thick endometrial wall. Maybe it would be good to have another one in a few months and see if there is progress there too? This is so new and it's disconcerting that the GYN is old school and does not have the latest information for us women. Thank you for your help.

May 23, 2011
Estrogen Dominant Reply
by: April Smith

Hi Wray, In your reply you said to start the Progesterone cream after ovulation starts. But you also said to take it all the time if the bleeding is continuing. Currently I am back on the cycle and hopefully it is going to stop normally this time. If it does should I wait 16 days before starting the Progesterone Cream? This cycle started 32 days after the last one started.

Thank you so much for your help. Also, I thought I had ordered but no where can I find my order withdrawn from the bank. I went ahead and ordered today.

[note from Natpro Support... your order was received and will ship on 25th May]

Jun 03, 2011
Estrogen Dominant Reply
by: Wray

Hi April If the ultra sound only found a thick endometrial wall and no other abnormality, then I can't see the point to it. If you're willing to put up with the heavy bleeding for a bit longer, then I would suggest trying the progesterone before having the D&C. It does take time to work, your idea of a couple of months sounds good. I do think you should use it daily too, but as you are back on your cycle again, see if things get better following this. You'll soon know if not, because once you stop the progesterone, symptoms of oestrogen dominance will occur again if you're not 'topped' up enough with progesterone. You said earlier that your cycle was 28 days, in which case you would start the progesterone on day 14. But this last cycle you say is 32 days, so ovulation would occur ┬▒day 18, which is when you should start the progesterone again. It leaves you with quite a long time without progesterone, and it could be this is one of the problems. But see how you get on. It could be your cycle is now becoming erratic, which it does in P-M. Please keep an eye on this, as it's impossible to follow the cycle if this occurs. It appears you haven't yet started the progesterone, please do read the page on Oestrogen Dominance again. And please be aware your first period could be very heavy with clots. It's nothing to worry about, just the progesterone 'cleaning' the uterus out. If you find relief from the bleeding, that it's stopped and not so heavy etc, you can decide whether you need another ultrasound or the D&C. Take care Wray

Jun 16, 2011
Estrogen Dominant and P/M
by: Anonymous

Hi Wray, I have been using the Progesterone Cream starting at day 18 from previous period. One week later the period started again. I am using approximately 400 mg's spread out 2 to three times a day. Should I just keep taking it everyday until my Estrogen is down and my period seems to be more predictable? This is supposed to be my ovulating time and the period started. Maybe I should continue the progesterone until the 14 days is up from when I started using it?
Thanks, April Smith.

Jun 24, 2011
Estrogen Dominant and P/M
by: Wray

Hi April Progesterone can disrupt the cycle when first using it, making it either early or late. I do feel it's best for you to use it daily, ignoring any bleeding when it occurs. It might be that you don't get a regular cycle back again, as you are at the tail end of peri-menopause. Unless your mother had a very late menopause, it's often a good guide as to when we go into it. The average age of menopause is 51. You're using a good amount too, and spread out over the day. You might like to read a comment made by another user who used high amounts, see here. So please try using it daily and see how you get on. Take care Wray

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