Estradiol Pessaries

by Majella Dorothy
(Ireland)

I had a smear recently and the G.P. that did the smear advised me about Estradiol Pessaries, 25mg, and how they may help with vaginal dryness and bladder urgency. I used the pessaries for 7 weeks and they helped a lot, but my G.P. (not the one who did the smear test) was not keen to do a repeat prescription as she said that they may cause problems later on.

My smear was normal, as was my mammography. No cancer history in family either. Will Progesterone help with my symptoms - hot flushes not really a problem but dryness and itching of skin is a problem as is bladder urgency. I am 54.

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Aug 16, 2011
Estradiol Pessaries
by: Wray

Hi Majella I do agree with your GP about the oestradiol, it's the most potent oestrogen too. We have more info on our HRT page. I have found using progesterone in the vagina very beneficial, many women have in fact. Progesterone is an anti-inflammatory, so does help if inflammation is present. It's also effective against Candida. It's also good for the skin, see here. The dryness and itching could be lack of the good fats and oils, please try increasing them. These are butter, olive oil, coconut oil and caprylic/capric triglycerides, often called MCT oil. Vitamin D is essential for a healthy skin, please have a test done. Ireland gets little sun to make vitamin D and most people there and in the UK have a low level, see here, here, here, here, here and here. For more info see the Vitamin D Council, GrassrootsHealth websites. And Birmingham Hospital now do testing for £20. The muscles of the bladder weaken with age, most probably due to a lack of vitamin D, it's essential for muscle strength. At the junction of the urethra and the bladder is a sphincter which controls the emptying of the bladder. Progesterone and oestrogen receptor sites are found in the urethra, so excess oestrogen can cause water retention. This in turn would swell the sphincter making it difficult to close. This is often the case in peri-menopause and menopause. I'm running out of space so will start a new comment below. Take care Wray

Aug 16, 2011
Estradiol Pessaries
by: Wray

Hi Majella Oestrogen causes contraction of smooth muscle, progesterone relaxes smooth muscle. Therefore excess oestrogen could lead to bladder spasms. Ironically when first using either progesterone or oestrogen, they stimulate the other hormone. Which is probably why the oestrogen helped. We have more info about this on our Oestrogen Dominance page. If you should consider progesterone, I recommend 100-200mg/day. But please read the page on oestrogen dominance first, as this can occur. And see our page on Menopause for more info on how to use it. Take care Wray

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