Estradiol level too high

by Donna
(Parma, Ohio, U.S.A.)

I am a 43 year old woman who has not had a period in over 9 months. I also have a list of symptoms which include extreme fatigue, weight gain (10+lbs. in the last 3 months), headaches, anxiety, just to mention a few!

I finally got my doctor to check my hormone levels. My estradiol level was over 740 the first time, so he re-tested and that one came back at 810! He ordered progesterone for me and I pick it up at the pharmacy tomorrow. I think it's the pill form. I am worried that it won't work after reading all the info on this website. I would love to hear any suggestions.

I also wanted to mention that I have been suffering from fibromyalgia for the last 8 years. I really want to get my life back. I am considering calling the doctor and ask him his opinion on the progesterone he ordered and the cream I can get on my own. Please help!

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Estradiol level too high

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Apr 08, 2009
 Estradiol level too high
by: Wray

Hi Donna. The symptoms you mentioned certainly fall into peri-menopause, which starts 5-10 years before menopause. The average age of this is 51.

It sounds as if you have developed insulin resistance, the weight gain and extreme fatigue are two symptoms of it. It can be reversed naturally, if interested please send me an email from the following web link:

http://www.progesteronetherapy.com/progesterone-faq.html

If the progesterone is oral very little is absorbed, so please check on this. You might like to read the following papers on absorption:

http://www.future-drugs.com/doi/abs/10.1586/17474108.1.2.173?cookieSet=1&journalCode=eog

http://humupd.oxfordjournals.org/cgi/content/abstract/6/2/139

http://humrep.oxfordjournals.org/cgi/content/abstract/14/8/1944

http://humrep.oxfordjournals.org/cgi/content/abstract/11/10/2085

Many authorities believe fibromyalgia is caused by a lack of serotonin. Progesterone does raise serotonin levels, but not sufficiently to help greatly. It might be necessary to take the precursor amino acid tryptophan, normally available in health shops. Take care, Wray.
Oct 07, 2009
 High level
by: Trace

I too have just had a test done and mine is raised also. I have to go back to my gp end of week. I have had the same symptoms as you but also no sex drive.
Apr 27, 2011
 oestradiol level
by: esther

I'm confused as i had my oesrtadiol level tested five days before my period & it 1,540ml which the doc said is fine im 33 & from what ihave read it seems too high to me? Please help!
May 11, 2011
 oestradiol level
by: Wray

If your level was 1.54 pg/ml and you're 33, then it is fine, unless your progesterone is very low. It's the ratio between the two hormones which is more important than the actual level. Take care Wray
Jun 12, 2011
 Estradiol level seems high
by: Anonymous

I recently had some bloodwork done on Day 22. My estradiol level was 380 pg/ml, which is double the level of previous tests. I am taking 100 mg. of compounded progesterone pills from Day 14 through the start of menstruation. Should I be concerned that the estradiol is so high? By the way, my progesterone was 22.20 ng/ml (day 22). Thanks for your help.
Jul 08, 2011
 High estradiol
by: Eileen

Hi -
I'm almost 46 and had blood work done on 6/30 to check hormones. I would like to become pregnant as soon as possible. Test results showed Estradiol level at 843, LH at 7.4, FSH at 6.5 and progesterone at <0.5. I've not had a regular cycle since March 27 altho I had some dark brown spotting that started on 6/23 that lasted about 3 days. Before March 27 my last cycle was in December. I had hoped the spotting last month was implantation bleeding but preg test was negative. My doc seems unconcerned about the Estradiol saying my hormones are "normal". They can't be normal or I'd be having regular cycles. She knows I am interested in conceiving. According to the "reference range" on the test results 843 is almost twice what the level should be even at average/normal peak levels. Hard to tell where I was in my "cycle" because of not having a normal cycle prior to that. I'm seeing higher numbers posted here and am wondering if mine is really high or just a little high and if it is the culprit in my irregular cycles.
Sep 27, 2011
 High Estradiol
by: JJG

I am 44 and recently received results of high estradiol level of 793. My doctored ordered a second estrogen test a week later with same resuls. He feels I am perimenapause because of other symptoms of irregularity. He prescribed a very low dose birth control pills and feels this will help. However, he sees no need to recheck my levels until next years annual check up. I am not sure I am satisfied.
Nov 27, 2011
 High Estradiol
by: Wray

Hi Anon, Eileen and JJG I do apologise about the late reply, I've no idea why your posts didn't come through to me. As they are all so similar and I'm so late in replying, I thought I'd cover them in one answer. Anon's oestradiol is just within the normal range, but Eileen's and JJG's is extremely high, see Medline Oestradiol. The ratio is the critical factor, we've found from Saliva Tests that it should be 600:1 and over to feel well. Anon's is 58:1, Eileen's is 0.5:1 and I can't give JJG's as there is no progesterone result. I can't see how a low dose pill will help, with what?! All Contraceptives have the potential to cause harm. It seems all of you could do with trying progesterone, I recommend 100-200mg/day, more if symptoms are severe. But before considering it, please see our page on Oestrogen Dominance as this can occur. Although Anon is taking oral progesterone, this is the least effective Delivery system. I suggest cutting open the caps and adding the contents to a small amount of cold pressed oil or a natural skin cream, and rubbing it on your skin. This way you'll get the full benefit of the progesterone. And Eileen we do have a page on Pregnancy you might like to look through. Take care Wray
Nov 29, 2011
 estrogen too high????
by: esther

Hi wray
In relation to my level it wasnt 1.54ml it was one thousand point five four!!

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