Can progesterone cream help me if I have Premature Ovarian Failure (POF)?

Hi Wray -

I've been diagnosed with POF - how likely is it that progesterone cream will induce a period? I would like to try and get pregnant naturally, but with my diagnosis and age, I'm not feeling very hopeful.

At age 39, I went off birth control pills after 18 years. I assumed my body was adjusting when my periods became irregular. However, after going 4 months without a period, I went to an endocrinologist who ran lab tests and received the following "post-menopausal" results:

FSH: 169
Estradiol = 32
AMH = < 0.03 (undetectable)

I was put on Provera for 10 days to induce a period which never came. 2 weeks later, I had an ultrasound done where 4 follicles at 8mm were found (2 on each side). The endocrinologist was surprised and told me I should expect a period soon.

My period did not come that month, so I began Chinese herbs and acupuncture. 2 months later, I finally got my period (after 200 days) and exactly 28 days later, I got another. I thought I was cured, but 8 months have passed again and no sign of a period.

Since then, I've been taking many supplements in addition to my herbs: multi-vitamin, CoQ10, ProOmega-D, Evening Primrose, Symplex F, Ovex and DHEA (25mg).

I also went to a compounding pharmacy to have saliva testing done. Results showed I was low in progesterone and DHEA. That's when I was prescribed natural progesterone cream to try and kickstart a period - however, it's been 2 months now with no luck.

I should mention that POF does not run in my family - my mom went through menopause at 55 and my sister is getting her period regularly at 47. I also tested negative for multiple antibodies tests, Fragile X, Turner's Syndrome, etc. I have no cysts,, no fibroids and my uterus is apparently very healthy.

Aside from amenorrhea and terrible numbers, I have no POF or menopausal symptoms - i.e. no hot flashes, no night sweats, no vaginal dryness, no brain fog, no insomnia. I eat mostly all organic food, exercise regularly and am not overly stressed.

Your thoughts and advice would be greatly appreciated. Thank you -

Click here to post comments

Join in and write your own page! It's easy to do. How? Simply click here to return to Progesterone faq.

Search over 7,500 pages on this site...